BNC2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: BNC2_HUMAN
• UniProt AC: Q6ZN30
• Protein Name: Zinc finger protein basonuclin-2
• Gene Name: BNC2 {ECO:0000312|HGNC:HGNC:30988}
• Organism: Homo sapiens (Human).
• Sequence Length: 1099
• Subcellular Localization: Nucleus .
• Protein Description: Probable transcription factor specific for skin keratinocytes. May play a role in the differentiation of spermatozoa and oocytes..
• Protein Sequence: MAHLGPTPPPHSLNYKSEDRLSEQDWPAYFKVPCCGVDTSQIESEEAEVDVRERETQRDREPKRARDLTLRDSCTDNSMQFGTRTTTAEPGFMGTWQNADTNLLFRMSQQAIRCTLVNCTCECFQPGKINLRTCDQCKHGWVAHALDKLSTQHLYHPTQVEIVQSNVVFDISSLMLYGTQAVPVRLKILLDRLFSVLKQEEVLHILHGLGWTLRDYVRGYILQDAAGKVLDRWAIMSREEEIITLQQFLRFGETKSIVELMAIQEKEGQAVAVPSSKTDSDIRTFIESNNRTRSPSLLAHLENSNPSSIHHFENIPNSLAFLLPFQYINPVSAPLLGLPPNGLLLEQPGLRLREPSLSTQNEYNESSESEVSPTPYKNDQTPNRNALTSITNVEPKTEPACVSPIQNSAPVSDLTKTEHPKSSFRIHRMRRMGSASRKGRVFCNACGKTFYDKGTLKIHYNAVHLKIKHRCTIEGCNMVFSSLRSRNRHSANPNPRLHMPMLRNNRDKDLIRATSGAATPVIASTKSNLALTSPGRPPMGFTTPPLDPVLQNPLPSQLVFSGLKTVQPVPPFYRSLLTPGEMVSPPTSLPTSPIIPTSGTIEQHPPPPSEPVVPAVMMATHEPSADLAPKKKPRKSSMPVKIEKEIIDTADEFDDEDDDPNDGGAVVNDMSHDNHCHSQEEMSPGMSVKDFSKHNRTRCISRTEIRRADSMTSEDQEPERDYENESESSEPKLGEESMEGDEHIHSEVSEKVLMNSERPDENHSEPSHQDVIKVKEEFTDPTYDMFYMSQYGLYNGGGASMAALHESFTSSLNYGSPQKFSPEGDLCSSPDPKICYVCKKSFKSSYSVKLHYRNVHLKEMHVCTVAGCNAAFPSRRSRDRHSANINLHRKLLTKELDDMGLDSSQPSLSKDLRDEFLVKIYGAQHPMGLDVREDASSPAGTEDSHLNGYGRGMAEDYMVLDLSTTSSLQSSSSIHSSRESDAGSDEGILLDDIDGASDSGESAHKAEAPALPGSLGAEVSGSLMFSSLSGSNGGIMCNICHKMYSNKGTLRVHYKTVHLREMHKCKVPGCNMMFSSVRSRNRHSQNPNLHKNIPFTSVD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
7	Phosphorylation	-MAHLGPTPPPHSLN -CCCCCCCCCCCCCC	46.78	22199227
12	Phosphorylation	GPTPPPHSLNYKSED CCCCCCCCCCCCCCC	24.88	24719451
17	Phosphorylation	PHSLNYKSEDRLSEQ CCCCCCCCCCCCCCC	34.08	24719451
22	Phosphorylation	YKSEDRLSEQDWPAY CCCCCCCCCCCCCCC	33.82	24961811
75	Phosphorylation	LTLRDSCTDNSMQFG CCCHHHCCCCCCCCC	42.01	22210691
78	Phosphorylation	RDSCTDNSMQFGTRT HHHCCCCCCCCCCEE	19.44	22210691
83	Phosphorylation	DNSMQFGTRTTTAEP CCCCCCCCEECCCCC	26.57	22210691
85	Phosphorylation	SMQFGTRTTTAEPGF CCCCCCEECCCCCCC	28.47	22210691
108	Phosphorylation	TNLLFRMSQQAIRCT CCHHHHHCHHHHHHE	18.19	-
150	Phosphorylation	AHALDKLSTQHLYHP HHHHHHHCCCCCCCC	31.59	24043423
151	Phosphorylation	HALDKLSTQHLYHPT HHHHHHCCCCCCCCC	30.37	24043423
155	Phosphorylation	KLSTQHLYHPTQVEI HHCCCCCCCCCCEEE	12.02	24043423
158	Phosphorylation	TQHLYHPTQVEIVQS CCCCCCCCCEEEEEC	31.75	24043423
165	Phosphorylation	TQVEIVQSNVVFDIS CCEEEEECCEEEEEH	22.24	24043423
172	Phosphorylation	SNVVFDISSLMLYGT CCEEEEEHHHHCCCC	21.18	24043423
173	Phosphorylation	NVVFDISSLMLYGTQ CEEEEEHHHHCCCCC	20.38	24043423
177	Phosphorylation	DISSLMLYGTQAVPV EEHHHHCCCCCCCCH	12.26	24043423
179	Phosphorylation	SSLMLYGTQAVPVRL HHHHCCCCCCCCHHH	10.37	24043423
220	Phosphorylation	LRDYVRGYILQDAAG HHHHHHHHHHHHHHH	6.46	20068231
275	O-linked_Glycosylation	GQAVAVPSSKTDSDI CCEEECCCCCCHHHH	37.56	30620550
277	Sumoylation	AVAVPSSKTDSDIRT EEECCCCCCHHHHHH	61.77	28112733
278	Phosphorylation	VAVPSSKTDSDIRTF EECCCCCCHHHHHHH	42.56	29449344
280	Phosphorylation	VPSSKTDSDIRTFIE CCCCCCHHHHHHHHH	39.92	29449344
284	Phosphorylation	KTDSDIRTFIESNNR CCHHHHHHHHHCCCC	29.33	29449344
288	Phosphorylation	DIRTFIESNNRTRSP HHHHHHHCCCCCCCH	34.29	29449344
292	Phosphorylation	FIESNNRTRSPSLLA HHHCCCCCCCHHHHH	37.31	24275569
356	Phosphorylation	GLRLREPSLSTQNEY CCCCCCCCCCCCCCC	30.14	30177828
358	Phosphorylation	RLREPSLSTQNEYNE CCCCCCCCCCCCCCC	32.08	30177828
359	Phosphorylation	LREPSLSTQNEYNES CCCCCCCCCCCCCCC	40.48	30177828
363	Phosphorylation	SLSTQNEYNESSESE CCCCCCCCCCCCCCC	31.60	30177828
366	Phosphorylation	TQNEYNESSESEVSP CCCCCCCCCCCCCCC	35.45	30177828
367	Phosphorylation	QNEYNESSESEVSPT CCCCCCCCCCCCCCC	38.67	30576142
369	Phosphorylation	EYNESSESEVSPTPY CCCCCCCCCCCCCCC	45.29	30177828
372	Phosphorylation	ESSESEVSPTPYKND CCCCCCCCCCCCCCC	21.00	30177828
374	Phosphorylation	SESEVSPTPYKNDQT CCCCCCCCCCCCCCC	31.57	30177828
376	Phosphorylation	SEVSPTPYKNDQTPN CCCCCCCCCCCCCCC	25.54	30177828
381	Phosphorylation	TPYKNDQTPNRNALT CCCCCCCCCCCCCCC	25.95	29507054
389	Phosphorylation	PNRNALTSITNVEPK CCCCCCCCCCCCCCC	28.41	28555341
396	Sumoylation	SITNVEPKTEPACVS CCCCCCCCCCCCCCC	52.60	28112733
397	Phosphorylation	ITNVEPKTEPACVSP CCCCCCCCCCCCCCC	58.90	30266825
403	Phosphorylation	KTEPACVSPIQNSAP CCCCCCCCCCCCCCC	19.03	30266825
408	Phosphorylation	CVSPIQNSAPVSDLT CCCCCCCCCCHHHCC	19.99	30266825
412	Phosphorylation	IQNSAPVSDLTKTEH CCCCCCHHHCCCCCC	26.33	30266825
415	Phosphorylation	SAPVSDLTKTEHPKS CCCHHHCCCCCCCCC	40.69	23403867
416	Sumoylation	APVSDLTKTEHPKSS CCHHHCCCCCCCCCH	60.25	28112733
421	Sumoylation	LTKTEHPKSSFRIHR CCCCCCCCCHHHHHH	61.72	28112733
422	Phosphorylation	TKTEHPKSSFRIHRM CCCCCCCCHHHHHHH	38.88	27251275
423	Phosphorylation	KTEHPKSSFRIHRMR CCCCCCCHHHHHHHH	25.35	27251275
482	Phosphorylation	GCNMVFSSLRSRNRH CCCHHHHHHHHCCCC	19.14	24719451
514	Phosphorylation	DKDLIRATSGAATPV CHHHHHHCCCCCCCE	20.18	29255136
515	Phosphorylation	KDLIRATSGAATPVI HHHHHHCCCCCCCEE	26.00	30266825
515	O-linked_Glycosylation	KDLIRATSGAATPVI HHHHHHCCCCCCCEE	26.00	30620550
519	Phosphorylation	RATSGAATPVIASTK HHCCCCCCCEEEECC	19.97	30266825
524	Phosphorylation	AATPVIASTKSNLAL CCCCEEEECCCCEEC	25.83	30266825
525	Phosphorylation	ATPVIASTKSNLALT CCCEEEECCCCEECC	29.48	30266825
527	Phosphorylation	PVIASTKSNLALTSP CEEEECCCCEECCCC	36.84	20068231
532	Phosphorylation	TKSNLALTSPGRPPM CCCCEECCCCCCCCC	27.54	20068231
533	Phosphorylation	KSNLALTSPGRPPMG CCCEECCCCCCCCCC	26.63	20068231
542	Phosphorylation	GRPPMGFTTPPLDPV CCCCCCCCCCCCCHH	32.44	20068231
543	Phosphorylation	RPPMGFTTPPLDPVL CCCCCCCCCCCCHHH	22.20	20068231
556	Phosphorylation	VLQNPLPSQLVFSGL HHCCCCCHHHHCCCC	43.77	20068231
561	Phosphorylation	LPSQLVFSGLKTVQP CCHHHHCCCCCCCCC	35.42	28112733
636	Phosphorylation	PKKKPRKSSMPVKIE CCCCCCCCCCCCEEE	32.90	30576142
641	Sumoylation	RKSSMPVKIEKEIID CCCCCCCEEEEEEEC	39.00	-
641	Sumoylation	RKSSMPVKIEKEIID CCCCCCCEEEEEEEC	39.00	28112733
687	Phosphorylation	EEMSPGMSVKDFSKH CCCCCCCCHHHHHHC	31.75	24719451
701	Phosphorylation	HNRTRCISRTEIRRA CCCCCCEEHHHHHHH	36.45	29449344
703	Phosphorylation	RTRCISRTEIRRADS CCCCEEHHHHHHHHC	29.04	29449344
710	Phosphorylation	TEIRRADSMTSEDQE HHHHHHHCCCCCCCC	23.99	29449344
712	Phosphorylation	IRRADSMTSEDQEPE HHHHHCCCCCCCCCC	32.68	29449344
713	Phosphorylation	RRADSMTSEDQEPER HHHHCCCCCCCCCCC	30.45	29449344
726	Phosphorylation	ERDYENESESSEPKL CCCCCCCCCCCCCCC	55.12	22468782
737	Phosphorylation	EPKLGEESMEGDEHI CCCCCCCCCCCCCHH	20.17	29255136
821	Phosphorylation	YGSPQKFSPEGDLCS CCCCCCCCCCCCCCC	29.13	27251275
828	Phosphorylation	SPEGDLCSSPDPKIC CCCCCCCCCCCCCEE	52.80	30266825
829	Phosphorylation	PEGDLCSSPDPKICY CCCCCCCCCCCCEEE	32.12	30266825
840	Acetylation	KICYVCKKSFKSSYS CEEEEECHHHCCCEE	56.87	15606023
843	Acetylation	YVCKKSFKSSYSVKL EEECHHHCCCEEEEE	45.65	15606031
849	Acetylation	FKSSYSVKLHYRNVH HCCCEEEEEEEECCC	24.49	15606039
885 (in isoform 2)	Phosphorylation	-	6.08	-
894	Sumoylation	LHRKLLTKELDDMGL HHHHHHHHHHHHCCC	57.14	28112733
894 (in isoform 2)	Phosphorylation	-	57.14	-
903	Phosphorylation	LDDMGLDSSQPSLSK HHHCCCCCCCCCCCH	35.60	24719451
904	Phosphorylation	DDMGLDSSQPSLSKD HHCCCCCCCCCCCHH	45.86	27251275
919	Sumoylation	LRDEFLVKIYGAQHP HHHHHHHHHHCCCCC	32.15	28112733
936	Phosphorylation	LDVREDASSPAGTED CCCCCCCCCCCCCCC	49.53	25850435
937	Phosphorylation	DVREDASSPAGTEDS CCCCCCCCCCCCCCC	22.08	25850435
941	Phosphorylation	DASSPAGTEDSHLNG CCCCCCCCCCCCCCC	38.43	25850435
944	Phosphorylation	SPAGTEDSHLNGYGR CCCCCCCCCCCCCCC	24.52	-
1075	Phosphorylation	PGCNMMFSSVRSRNR CCCCCCCCHHHCCCC	15.27	27732954
1076	Phosphorylation	GCNMMFSSVRSRNRH CCCCCCCHHHCCCCC	15.41	27732954

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of BNC2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of BNC2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of BNC2_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of BNC2_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.