TIMP2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TIMP2_HUMAN
• UniProt AC: P16035
• Protein Name: Metalloproteinase inhibitor 2
• Gene Name: TIMP2
• Organism: Homo sapiens (Human).
• Sequence Length: 220
• Subcellular Localization: Secreted.
• Protein Description: Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-13, MMP-14, MMP-15, MMP-16 and MMP-19..
• Protein Sequence: MGAAARTLRLALGLLLLATLLRPADACSCSPVHPQQAFCNADVVIRAKAVSEKEVDSGNDIYGNPIKRIQYEIKQIKMFKGPEKDIEFIYTAPSSAVCGVSLDVGGKKEYLIAGKAEGDGKMHITLCDFIVPWDTLSTTQKKSLNHRYQMGCECKITRCPMIPCYISSPDECLWMDWVTEKNINGHQAKFFACIKRSDGSCAWYRGAAPPKQEFLDIEDP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
53	Ubiquitination	RAKAVSEKEVDSGND EEECCCHHHCCCCCC	56.37	-
57	Phosphorylation	VSEKEVDSGNDIYGN CCHHHCCCCCCCCCC	44.67	-
62	Phosphorylation	VDSGNDIYGNPIKRI CCCCCCCCCCHHHHH	17.45	-
67	Ubiquitination	DIYGNPIKRIQYEIK CCCCCHHHHHEEEEE	44.71	-
74	Ubiquitination	KRIQYEIKQIKMFKG HHHEEEEEEEECCCC	33.75	-
90	Phosphorylation	EKDIEFIYTAPSSAV CCCCEEEEECCCCCE	11.36	-
165	Phosphorylation	RCPMIPCYISSPDEC CCCCCCEEECCCCCE	9.85	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
62	Y	Phosphorylation	Kinase	SRC	P12931	PSP
90	Y	Phosphorylation	Kinase	SRC	P12931	PSP
165	Y	Phosphorylation	Kinase	SRC	P12931	PSP

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TIMP2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TIMP2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SYUG_HUMAN	SNCG	physical	17353931
PSA7_HUMAN	PSMA7	physical	17353931
MMP2_HUMAN	MMP2	physical	10991943
MMP14_HUMAN	MMP14	physical	9422789
MMP2_HUMAN	MMP2	physical	9182583
TIMP3_HUMAN	TIMP3	physical	26186194
HEMH_HUMAN	FECH	physical	26186194
ZMYM6_HUMAN	ZMYM6	physical	26186194
PCSK5_MOUSE	Pcsk5	physical	16135528
HEMH_HUMAN	FECH	physical	28514442
TIMP3_HUMAN	TIMP3	physical	28514442
ZMYM6_HUMAN	ZMYM6	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.