PCSK5_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PCSK5_MOUSE
• UniProt AC: Q04592
• Protein Name: Proprotein convertase subtilisin/kexin type 5
• Gene Name: Pcsk5
• Organism: Mus musculus (Mouse).
• Sequence Length: 1877
• Subcellular Localization: Isoform PC5A: Secreted. Secreted through the regulated secretory pathway.; Isoform PC5B: Endomembrane system; Single-pass type I membrane protein. Type I membrane protein localized to a paranuclear post-Golgi network compartment in communication
• Protein Description: Serine endoprotease that processes various proproteins by cleavage at paired basic amino acids, recognizing the RXXX[KR]R consensus motif. Likely functions in the constitutive and regulated secretory pathways. Plays an essential role in pregnancy establishment by proteolytic activation of a number of important factors such as BMP2, CALD1 and alpha-integrins. May be responsible for the maturation of gastrointestinal peptides. May be involved in the cellular proliferation of adrenal cortex via the activation of growth factors..
• Protein Sequence: MDWDWGNRCSRPGRRDLLCVLALLAGCLLPVCRTRVYTNHWAVKIAGGFAEADRIASKYGFINVGQIGALKDYYHFYHSRTIKRSVLSSRGTHSFISMEPKVEWIQQQVVKKRTKRDYDLSHAQSTYFNDPKWPSMWYMHCSDNTHPCQSDMNIEGAWKRGYTGKNIVVTILDDGIERTHPDLMQNYDALASCDVNGNDLDPMPRYDASNENKHGTRCAGEVAATANNSHCTVGIAFNAKIGGVRMLDGDVTDMVEAKSVSYNPQHVHIYSASWGPDDDGKTVDGPAPLTRQAFENGVRMGRRGLGSVFVWASGNGGRSKDHCSCDGYTNSIYTISISSTAESGKKPWYLEECSSTLATTYSSGESYDKKIITTDLRQRCTDNHTGTSASAPMAAGIIALALEANPFLTWRDVQHVIVRTSRAGHLNANDWKTNAAGFKVSHLYGFGLMDAEAMVMEAEKWTTVPQQHVCVESTDRQIKTIRPNSAVRSIYKASGCSDNPNHHVNYLEHVVVRITITHPRRGDLAIYLTSPSGTRSQLLANRLFDHSMEGFKNWEFMTIHCWGERAAGDWVLEVYDTPSQLRNFKTPGKLKEWSLVLYGTSVQPYSPTNEFPKVERFRYSRVEDPTDDYGAEDYAGPCDPECSEVGCDGPGPDHCSDCLHYYYKLKNNTRICVSSCPPGHYHADKKRCRKCAPNCESCFGSHGNQCLSCKYGYFLNEETSSCVTQCPDGSYEDIKKNVCGKCSENCKACIGFHNCTECKGGLSLQGSRCSVTCEDGQFFNGHDCQPCHRFCATCSGAGADGCINCTEGYVMEEGRCVQSCSVSYYLDHSSEGGYKSCKRCDNSCLTCNGPGFKNCSSCPSGYLLDLGTCQMGAICKDGEYIDDQGHCQTCEASCAKCWGPTQEDCISCPVTRVLDDGRCVMNCPSWKFEFKKQCHPCHYTCQGCQGSGPSNCTSCRADKHGQERFLYHGECLENCPVGHYPAKGHACLPCPDNCELCYNPHVCSRCMSGYVIIPPNHTCQKLECRQGEFQDSEYEECMPCEEGCLGCTEDDPGACTSCATGYYMFERHCYKACPEKTFGVKWECRACGTNCGSCDQHECYWCEEGFFLSGGSCVQDCGPGFHGDQELGECKPCHRACENCTGSGYNQCSSCQEGLQLWHGTCLWSTWPQVEGKDWNEAVPTEKPSLVRSLLQDRRKWKVQIKRDATSQNQPCHSSCKTCNGSLCASCPTGMYLWLQACVPSCPQGTWPSVTSGSCEKCSEDCVSCSGADLCQQCLSQPDNTLLLHEGRCYHSCPEGFYAKDGVCEHCSSPCKTCEGNATSCNSCEGDFVLDHGVCWKTCPEKHVAVEGVCKHCPERCQDCIHEKTCKECMPDFFLYNDMCHRSCPKSFYPDMRQCVPCHKNCLECNGPKEDDCKVCADTSKALHNGLCLDECPEGTYKEEENDECRDCPESCLICSSAWTCLACREGFTVVHDVCTAPKECAAVEYWDEGSHRCQPCHKKCSRCSGPSEDQCYTCPRETFLLNTTCVKECPEGYHTDKDSQQCVLCHSSCRTCEGPHSMQCLSCRPGWFQLGKECLLQCRDGYYGESTSGRCEKCDKSCKSCRGPRPTDCQSCDTFFFLLRSKGQCHRACPEHYYADQHAQTCERCHPTCDKCSGKEAWSCLSCVWSYHLLKGICIPECIVGEYREGKGENFNCKKCHESCMECKGPGSKNCTGCSAGLLLDMDDNRCLHCCNASHSRRSQDCCDCQSSTDECILPAREAEFYEHTKTALLVTSGAMLLLLLGAAAVVWRKSRSRPVAKGRYEKLAEPTVSYSSYRSSYLDEDQVIEYRDRDYDEDDEDDIVYMGQDGTVYRKFKYGLLDETEDDELEYDDESYSYQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
88	Phosphorylation	TIKRSVLSSRGTHSF CCHHHHHHCCCCCCC	18.81	21743459
89	Phosphorylation	IKRSVLSSRGTHSFI CHHHHHHCCCCCCCC	30.48	21743459
227	N-linked_Glycosylation	GEVAATANNSHCTVG HHHHHHCCCCCCEEE	46.30	-
319	Phosphorylation	ASGNGGRSKDHCSCD ECCCCCCCCCCEECC	45.79	24759943
324	Phosphorylation	GRSKDHCSCDGYTNS CCCCCCEECCCCCCE	16.30	24759943
329	Phosphorylation	HCSCDGYTNSIYTIS CEECCCCCCEEEEEE	28.19	24759943
331	Phosphorylation	SCDGYTNSIYTISIS ECCCCCCEEEEEEEE	14.79	24759943
333	Phosphorylation	DGYTNSIYTISISST CCCCCEEEEEEEEEC	9.61	24759943
383	N-linked_Glycosylation	LRQRCTDNHTGTSAS HHHHHCCCCCCCCCC	19.23	-
515	Phosphorylation	EHVVVRITITHPRRG EEEEEEEEECCCCCC	14.84	22006019
517	Phosphorylation	VVVRITITHPRRGDL EEEEEEECCCCCCCE	19.71	22006019
667	N-linked_Glycosylation	HYYYKLKNNTRICVS HHHHCCCCCCEEEEE	66.59	-
754	N-linked_Glycosylation	KACIGFHNCTECKGG CCEEEECCCCCCCCC	31.95	-
804	N-linked_Glycosylation	AGADGCINCTEGYVM CCCCCCEECCCCEEE	30.63	-
854	N-linked_Glycosylation	CNGPGFKNCSSCPSG CCCCCCCCCCCCCCC	28.74	-
951	N-linked_Glycosylation	CQGSGPSNCTSCRAD CCCCCCCCCCCCCCC	35.90	-
980	Phosphorylation	ENCPVGHYPAKGHAC HCCCCCCCCCCCCCC	10.04	29899451
1016	N-linked_Glycosylation	GYVIIPPNHTCQKLE CEEEECCCCCCCEEE	37.43	-
1220	N-linked_Glycosylation	HSSCKTCNGSLCASC CCCCCCCCCCEECCC	48.60	-
1317	N-linked_Glycosylation	PCKTCEGNATSCNSC CCCCCCCCCCCCCCC	20.11	-
1523	N-linked_Glycosylation	PRETFLLNTTCVKEC CCCEEEEECEEECCC	35.17	-
1583	Phosphorylation	LLQCRDGYYGESTSG HHCCCCCCCCCCCCC	16.76	21659605
1711	N-linked_Glycosylation	CKGPGSKNCTGCSAG CCCCCCCCCCCCCCE	30.22	-
1733	N-linked_Glycosylation	NRCLHCCNASHSRRS CCCCCCCCCCCCCCC	50.28	-
1804	Ubiquitination	VAKGRYEKLAEPTVS CCCCCHHHHCCCCCC	44.02	22790023
1833	Phosphorylation	IEYRDRDYDEDDEDD EEECCCCCCCCCCCC	23.33	-
1843	Phosphorylation	DDEDDIVYMGQDGTV CCCCCEEEECCCCCE	8.89	-
1849	Phosphorylation	VYMGQDGTVYRKFKY EEECCCCCEEEEECC	23.74	-
1851	Phosphorylation	MGQDGTVYRKFKYGL ECCCCCEEEEECCCC	14.13	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PCSK5_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PCSK5_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PCSK5_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of PCSK5_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.