THI22_SCHPO - dbPTM
THI22_SCHPO - PTM Information in dbPTM
Basic Information of Protein
UniProt ID THI22_SCHPO
UniProt AC O94266
Protein Name Putative hydroxymethylpyrimidine/phosphomethylpyrimidine kinase 2
Gene Name SPBP8B7.18c
Organism Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
Sequence Length 551
Subcellular Localization Cytoplasm .
Protein Description Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP, and of HMP to HMP-P..
Protein Sequence MPYNPLYESLSNQFDPSRIETVLDPMGYTIKRRALPVSLTIAGSDCSGGAGIQADLKTMTSLGVYGMSAITCLVAENAGGVDSVEEMSPAFVESQIDCCIRDIPCHVVKTGMLGSPEIVKAVARSAKKFNFSKLVVDPVMVATSGDSLVTKDIVSVLNEELLPLTYLVTPNIPEAIVLAKNQGLDISNINSVSDMERCAAVIHKLGPKHVLLKGGHMPVNNLGLKSSDDEDLRVVDILYDGNRFYHFSSSYLKKGEVHGTGCTLSSAIASFLAWEHSLTEAVQFGIDYVHGAITHSPPINNCSTNILNHMTRLRIVPFAPGHFIEYILSHPQVVPAWKEYINHKFTNMLAKGTLPLPAFQDYLKQDYLYLVNFARAYSLKGYKENTFPNILEAAQSVIHVIEEKELHVSMCSSYGVSLQDLKSCEESPACTAYSRYILDTGAAQDVAALDFVQAPCLIGYYVIAARLMKEPFRNPQGPYQKWVDNYFCEDYLSAVRRGCRQIEEIVLKLSPERIQELIEIFIRATKFETLFWETPYYEYVTKQNLEDKEFS
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
115PhosphorylationVKTGMLGSPEIVKAV
EECCCCCCHHHHHHH		18.5225720772
226PhosphorylationVNNLGLKSSDDEDLR
CCCCCCCCCCCCCCE		44.0025720772
227PhosphorylationNNLGLKSSDDEDLRV
CCCCCCCCCCCCCEE		47.7125720772
433PhosphorylationESPACTAYSRYILDT
CCCCCCHHHHHEECC		3.8925720772
551PhosphorylationNLEDKEFS-------
CCCCCCCC-------		40.1625720772
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of THI22_SCHPO !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of THI22_SCHPO !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of THI22_SCHPO !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
RIK1_SCHPOrik1genetic
18818364
SWC5_SCHPOswc5genetic
18818364
YHZ8_SCHPOSPBC21B10.08cgenetic
22681890
THI9_SCHPOthi9genetic
22681890
YH51_SCHPOSPBC215.01genetic
22681890
ADH4_SCHPOadh4genetic
22681890
PSL1_SCHPOpsl1genetic
22681890
ATG20_SCHPOatg20genetic
22681890
ALAT_SCHPOSPBC582.08genetic
22681890
YHZ7_SCHPOSPBC21B10.07genetic
22681890
THI22_SCHPOSPBP8B7.18cphysical
26771498
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of THI22_SCHPO

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Related Literatures of Post-Translational Modification

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