| UniProt ID | TGM5_HUMAN | |
|---|---|---|
| UniProt AC | O43548 | |
| Protein Name | Protein-glutamine gamma-glutamyltransferase 5 | |
| Gene Name | TGM5 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 720 | |
| Subcellular Localization | Cytoplasm . Associated with intermediate filaments. | |
| Protein Description | Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins. Contributes to the formation of the cornified cell envelope of keratinocytes.. | |
| Protein Sequence | MAQGLEVALTDLQSSRNNVRHHTEEITVDHLLVRRGQAFNLTLYFRNRSFQPGLDNIIFVVETGPLPDLALGTRAVFSLARHHSPSPWIAWLETNGATSTEVSLCAPPTAAVGRYLLKIHIDSFQGSVTAYQLGEFILLFNPWCPEDAVYLDSEPQRQEYVMNDYGFIYQGSKNWIRPCPWNYGQFEDKIIDICLKLLDKSLHFQTDPATDCALRGSPVYVSRVVCAMINSNDDNGVLNGNWSENYTDGANPAEWTGSVAILKQWNATGCQPVRYGQCWVFAAVMCTVMRCLGIPTRVITNFDSGHDTDGNLIIDEYYDNTGRILGNKKKDTIWNFHVWNECWMARKDLPPAYGGWQVLDATPQEMSNGVYCCGPASVRAIKEGEVDLNYDTPFVFSMVNADCMSWLVQGGKEQKLHQDTSSVGNFISTKSIQSDERDDITENYKYEEGSLQERQVFLKALQKLKARSFHGSQRGAELQPSRPTSLSQDSPRSLHTPSLRPSDVVQVSLKFKLLDPPNMGQDICFVLLALNMSSQFKDLKVNLSAQSLLHDGSPLSPFWQDTAFITLSPKEAKTYPCKISYSQYSQYLSTDKLIRISALGEEKSSPEKILVNKIITLSYPSITINVLGAAVVNQPLSIQVIFSNPLSEQVEDCVLTVEGSGLFKKQQKVFLGVLKPQHQASIILETVPFKSGQRQIQANMRSNKFKDIKGYRNVYVDFAL | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 2 | Acetylation | ------MAQGLEVAL ------CCCCCEEEH | 16.49 | 15290349 | |
| 10 | Phosphorylation | QGLEVALTDLQSSRN CCCEEEHHHHHHHCC | 25.56 | 28122231 | |
| 14 | Phosphorylation | VALTDLQSSRNNVRH EEHHHHHHHCCCCCC | 38.26 | 28122231 | |
| 15 | Phosphorylation | ALTDLQSSRNNVRHH EHHHHHHHCCCCCCC | 26.52 | 28122231 | |
| 78 | Phosphorylation | LGTRAVFSLARHHSP HHHHHHHHHHHCCCC | 17.96 | 22964224 | |
| 217 | Phosphorylation | TDCALRGSPVYVSRV CCHHHCCCCEEEEEE | 12.54 | 28796482 | |
| 220 | Phosphorylation | ALRGSPVYVSRVVCA HHCCCCEEEEEEEEE | 8.97 | 28796482 | |
| 468 | Phosphorylation | LQKLKARSFHGSQRG HHHHHHHHCCCCCCC | 26.84 | 30631047 | |
| 481 | Phosphorylation | RGAELQPSRPTSLSQ CCCCCCCCCCCCCCC | 37.62 | 30631047 | |
| 484 | Phosphorylation | ELQPSRPTSLSQDSP CCCCCCCCCCCCCCC | 40.98 | - | |
| 485 | Phosphorylation | LQPSRPTSLSQDSPR CCCCCCCCCCCCCCC | 28.80 | - | |
| 490 | Phosphorylation | PTSLSQDSPRSLHTP CCCCCCCCCCCCCCC | 17.99 | - | |
| 498 | Phosphorylation | PRSLHTPSLRPSDVV CCCCCCCCCCHHHCE | 37.86 | 24719451 | |
| 568 | Phosphorylation | DTAFITLSPKEAKTY CEEEEEECHHHHCCC | 25.85 | 24719451 | |
| 575 | Phosphorylation | SPKEAKTYPCKISYS CHHHHCCCCCEEEHH | 13.11 | 22817900 | |
| 581 | Phosphorylation | TYPCKISYSQYSQYL CCCCEEEHHHHHHHC | 11.85 | 22817900 | |
| 587 | Phosphorylation | SYSQYSQYLSTDKLI EHHHHHHHCCCCCEE | 9.18 | 22817900 | |
| 681 | Phosphorylation | LKPQHQASIILETVP CCCHHHEEEEEEECC | 12.00 | 22210691 | |
| 686 | Phosphorylation | QASIILETVPFKSGQ HEEEEEEECCCCCCH | 29.99 | 22210691 | |
| 691 | Phosphorylation | LETVPFKSGQRQIQA EEECCCCCCHHHHHH | 40.30 | 22210691 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of TGM5_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of TGM5_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of TGM5_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| SPICE_HUMAN | SPICE1 | physical | 28514442 | |
| RFTN1_HUMAN | RFTN1 | physical | 28514442 | |
| UBB_HUMAN | UBB | physical | 28514442 | |
| BCD1_HUMAN | ZNHIT6 | physical | 28514442 | |
| DOCK7_HUMAN | DOCK7 | physical | 28514442 | |
| PDZ11_HUMAN | PDZD11 | physical | 28514442 | |
| IF4E2_HUMAN | EIF4E2 | physical | 28514442 | |
| RPA43_HUMAN | TWISTNB | physical | 28514442 | |
| INT14_HUMAN | VWA9 | physical | 28514442 |
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| Acetylation | |
| Reference | PubMed |
| "Transglutaminase 5 is acetylated at the N-terminal end."; Rufini A., Vilbois F., Paradisi A., Oddi S., Tartaglione R., Leta A.,Bagetta G., Guerrieri P., Finazzi-Agro' A., Melino G., Candi E.; Amino Acids 26:425-430(2004). Cited for: PROTEIN SEQUENCE OF 2-16, SUBCELLULAR LOCATION, ACETYLATION AT ALA-2,INDUCTION BY TPA AND CALCIUM, AND MASS SPECTROMETRY. | |
