| UniProt ID | T22D3_MOUSE | |
|---|---|---|
| UniProt AC | Q9Z2S7 | |
| Protein Name | TSC22 domain family protein 3 | |
| Gene Name | Tsc22d3 | |
| Organism | Mus musculus (Mouse). | |
| Sequence Length | 137 | |
| Subcellular Localization |
Isoform 1: Cytoplasm. Nucleus. Localization depends on differentiation status of myoblasts. In undifferentiated myoblasts, isoform 1 localizes to the cytoplasm, but in differentiating myoblasts, isoform 1 is localized to the nucleus. Isoform 4: Cyto |
|
| Protein Description | Protects T-cells from IL2 deprivation-induced apoptosis through the inhibition of FOXO3A transcriptional activity that leads to the down-regulation of the pro-apoptotic factor BCL2L11. In macrophages, plays a role in the anti-inflammatory and immunosuppressive effects of glucocorticoids and IL10. In T-cells, inhibits anti-CD3-induced NFKB1 nuclear translocation. In vitro, suppresses AP1 and NFKB1 DNA-binding activities (By similarity). Isoform 1 and isoform 4 inhibit myogenic differentiation and mediate anti-myogenic effects of glucocorticoids by binding and regulating MYOD1 and HDAC1 transcriptional activity resulting in reduced expression of MYOG.. | |
| Protein Sequence | MNTEMYQTPMEVAVYQLHNFSISFFSSLLGGDVVSVKLDNSASGASVVALDNKIEQAMDLVKNHLMYAVREEVEVLKEQIRELLEKNSQLERENTLLKTLASPEQLEKFQSRLSPEEPAPEAPETPETPEAPGGSAV | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 6 (in isoform 3) | Phosphorylation | - | 11.73 | 21183079 | |
| 7 (in isoform 4) | Phosphorylation | - | 37.51 | 28464351 | |
| 8 (in isoform 4) | Phosphorylation | - | 13.71 | 28464351 | |
| 10 (in isoform 3) | Phosphorylation | - | 8.00 | 27742792 | |
| 34 (in isoform 3) | Phosphorylation | - | 6.92 | 26239621 | |
| 37 (in isoform 3) | Phosphorylation | - | 42.49 | 26239621 | |
| 39 (in isoform 4) | Phosphorylation | - | 41.12 | 21183079 | |
| 40 (in isoform 3) | Phosphorylation | - | 50.33 | 26239621 | |
| 43 (in isoform 4) | Phosphorylation | - | 34.41 | 27742792 | |
| 43 | Phosphorylation | VKLDNSASGASVVAL EEECCCCCCCEEEEE | 34.41 | - | |
| 44 (in isoform 3) | Phosphorylation | - | 22.91 | 25777480 | |
| 46 | Phosphorylation | DNSASGASVVALDNK CCCCCCCEEEEECCH | 22.20 | - | |
| 52 (in isoform 3) | Ubiquitination | - | 48.32 | - | |
| 62 (in isoform 3) | Ubiquitination | - | 46.04 | - | |
| 67 (in isoform 4) | Phosphorylation | - | 14.33 | 26239621 | |
| 70 (in isoform 4) | Phosphorylation | - | 26.62 | 26239621 | |
| 71 (in isoform 3) | Phosphorylation | - | 60.85 | 23737553 | |
| 73 (in isoform 4) | Phosphorylation | - | 5.44 | 26239621 | |
| 77 | Ubiquitination | REEVEVLKEQIRELL HHHHHHHHHHHHHHH | 53.39 | - | |
| 77 (in isoform 4) | Phosphorylation | - | 53.39 | 25777480 | |
| 81 (in isoform 3) | Phosphorylation | - | 28.36 | 23984901 | |
| 85 | Ubiquitination | EQIRELLEKNSQLER HHHHHHHHHCCHHHH | 63.92 | 22790023 | |
| 95 | Ubiquitination | SQLERENTLLKTLAS CHHHHHHHHHHHHCC | 28.81 | 22790023 | |
| 99 | Phosphorylation | RENTLLKTLASPEQL HHHHHHHHHCCHHHH | 27.76 | 22942356 | |
| 102 | Phosphorylation | TLLKTLASPEQLEKF HHHHHHCCHHHHHHH | 31.89 | 26643407 | |
| 104 (in isoform 4) | Phosphorylation | - | 66.36 | 23737553 | |
| 108 | Ubiquitination | ASPEQLEKFQSRLSP CCHHHHHHHHHHCCC | 58.24 | - | |
| 111 | Phosphorylation | EQLEKFQSRLSPEEP HHHHHHHHHCCCCCC | 38.02 | 25338131 | |
| 114 (in isoform 4) | Phosphorylation | - | 29.20 | 23984901 | |
| 114 | Phosphorylation | EKFQSRLSPEEPAPE HHHHHHCCCCCCCCC | 29.20 | 25619855 | |
| 125 | Phosphorylation | PAPEAPETPETPEAP CCCCCCCCCCCCCCC | 25.93 | 25521595 | |
| 128 | Phosphorylation | EAPETPETPEAPGGS CCCCCCCCCCCCCCC | 27.86 | 25521595 | |
| 135 | Phosphorylation | TPEAPGGSAV----- CCCCCCCCCC----- | 31.60 | 28066266 | |
| 174 | Ubiquitination | -------------------------------------------- -------------------------------------------- | 22790023 | ||
| 205 | Ubiquitination | --------------------------------------------------------------------------- --------------------------------------------------------------------------- | 22790023 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of T22D3_MOUSE !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of T22D3_MOUSE !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of T22D3_MOUSE !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| HXA6_MOUSE | Hoxa6 | physical | 20211142 | |
| HXB8_MOUSE | Hoxb8 | physical | 20211142 | |
| TFE2_MOUSE | Tcf3 | physical | 20211142 | |
| MYOD1_MOUSE | Myod1 | physical | 20124407 | |
| DAB2_MOUSE | Dab2 | physical | 11104669 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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