dbPTM

SYH_SCHPO - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	SYH_SCHPO
UniProt AC	O43011
Protein Name	Histidine--tRNA ligase, mitochondrial
Gene Name	hts1
Organism	Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
Sequence Length	563
Subcellular Localization	Mitochondrion. Cytoplasm .
Protein Description	Catalyzes the aminoacylation of histidyl-tRNA in both the cytoplasm and the mitochondrion..
Protein Sequence	MFVFTKNLFTTKFSSSLLNWRFLRTMADSLVDINERITSQGNLVRSLKSQGASKEDIDKEVAKLLQLKNLKLGGSEVSGKKKDTSFTLKTPKGTKDWCDKDVVLREHIFSTVTEIFKRHGGVTLDTPVFELKEILSGKYGEDSKLIYDLKDQGGELCSLRYDLTVPFARWLAMNPKVTSIKRFHIAKVYRRDQPAMTKGRMREFYQCDFDIAGNYDPMIPDSEALKVLVEALDALEVGNYTIKLNHRKILDGIFTVCGVPDDKIRTISSAVDKLDKLPWEDVRREMVVEKGLKEEVADKIKEYVLLKGDRSLLDKLEADSLLSSNSSAVAAFNDMRLLFDYLEAFGVLDRFSFDMSLARGLDYYTGIIYEAVTEASAPKIKSSAEKKKSADPEADRSNDDSIGVGSIAAGGRYDNLVGMFAAKKNAKIPCVGISLGLERIFSILRSKIPDEDIRANDVDVFVMAFGGGKEWTGFLKERMSVCKDLWANGIKAEFLYKVKPKPRQQFDAADKFDVPFAVILGQDEFAKGSVRIKQMGLKENSDEGQLVPREEMVSVLKKLLKYD

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
29	Phosphorylation	FLRTMADSLVDINER HHHHHHHHHCCHHHH	59.89	24763107
39	Phosphorylation	DINERITSQGNLVRS CHHHHHHHHHHHHHH	2.38	25720772
46	Phosphorylation	SQGNLVRSLKSQGAS HHHHHHHHHHHCCCC	55.25	21712547
49	Phosphorylation	NLVRSLKSQGASKED HHHHHHHHCCCCHHH	30.94	25720772
53	Phosphorylation	SLKSQGASKEDIDKE HHHHCCCCHHHHHHH	40.62	25720772
85	Phosphorylation	SGKKKDTSFTLKTPK CCCCCCCCEEEECCC	22.74	25720772
90	Phosphorylation	DTSFTLKTPKGTKDW CCCEEEECCCCCCCC	3.44	28889911

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of SYH_SCHPO !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of SYH_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of SYH_SCHPO !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
KMS1_SCHPO	kms1	physical	22425159
ALP4_SCHPO	alp4	physical	22425159
SYH_SCHPO	hrs1	physical	22425159
KMS2_SCHPO	kms2	physical	22425159
MAD2_SCHPO	mad2	genetic	22425159

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of SYH_SCHPO

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Phosphoproteome analysis of fission yeast."; Wilson-Grady J.T., Villen J., Gygi S.P.; J. Proteome Res. 7:1088-1097(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-65, AND MASSSPECTROMETRY.	18257517 [Abstract]