STK35_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: STK35_HUMAN
• UniProt AC: Q8TDR2
• Protein Name: Serine/threonine-protein kinase 35
• Gene Name: STK35
• Organism: Homo sapiens (Human).
• Sequence Length: 534
• Subcellular Localization: Nucleus. Nucleus, nucleolus. Cytoplasm. When associated with PDLIM1, it is mostly found in cytoplasm, localized to actin stress fibers (PubMed:11973348). However, PubMed:19756140 detected STK35 only in the nucleus, and the presence of PDLIM1 had no i
• Protein Sequence: MGHQESPLARAPAGGAAYVKRLCKGLSWREHVESHGSLGAQASPASAAAAEGSATRRARAATSRAARSRRQPGPGADHPQAGAPGGKRAARKWRCAGQVTIQGPAPPRPRAGRRDEAGGARAAPLLLPPPPAAMETGKDGARRGTQSPERKRRSPVPRAPSTKLRPAAAARAMDPVAAEAPGEAFLARRRPEGGGGSARPRYSLLAEIGRGSYGVVYEAVAGRSGARVAVKKIRCDAPENVELALAEFWALTSLKRRHQNVVQFEECVLQRNGLAQRMSHGNKSSQLYLRLVETSLKGERILGYAEEPCYLWFVMEFCEGGDLNQYVLSRRPDPATNKSFMLQLTSAIAFLHKNHIVHRDLKPDNILITERSGTPILKVADFGLSKVCAGLAPRGKEGNQDNKNVNVNKYWLSSACGSDFYMAPEVWEGHYTAKADIFALGIIIWAMIERITFIDSETKKELLGTYIKQGTEIVPVGEALLENPKMELHIPQKRRTSMSEGIKQLLKDMLAANPQDRPDAFELETRMDQVTCAA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
6	Phosphorylation	--MGHQESPLARAPA --CCCCCCCCCCCCC	20.74	25159151
27	Phosphorylation	KRLCKGLSWREHVES HHHHCCCCHHHHHHH	32.52	24719451
34	Phosphorylation	SWREHVESHGSLGAQ CHHHHHHHHCCCCCC	31.87	-
68	Phosphorylation	ATSRAARSRRQPGPG HHHHHHHHHCCCCCC	27.39	22210691
145	Phosphorylation	KDGARRGTQSPERKR CCCCCCCCCCCCHHC	24.86	18691976
202	Phosphorylation	GGSARPRYSLLAEIG CCCCCCCCHHEEEEC	13.32	18083107
203	Phosphorylation	GSARPRYSLLAEIGR CCCCCCCHHEEEECC	20.41	-
212	Phosphorylation	LAEIGRGSYGVVYEA EEEECCCCCEEEEEE	19.83	-
213	Phosphorylation	AEIGRGSYGVVYEAV EEECCCCCEEEEEEC	19.43	18083107
217	Phosphorylation	RGSYGVVYEAVAGRS CCCCEEEEEECCCCC	8.86	18083107
297	Ubiquitination	RLVETSLKGERILGY HHHHHHCCCCEECEE	59.50	-
362	Ubiquitination	HIVHRDLKPDNILIT CEECCCCCCCCEEEE	55.40	29967540
369	Phosphorylation	KPDNILITERSGTPI CCCCEEEECCCCCEE	23.15	28111955
372	Phosphorylation	NILITERSGTPILKV CEEEECCCCCEEEEE	40.56	28111955
374	Phosphorylation	LITERSGTPILKVAD EEECCCCCEEEEEHH	14.38	24719451
378	Ubiquitination	RSGTPILKVADFGLS CCCCEEEEEHHHCHH	35.78	-
385	Phosphorylation	KVADFGLSKVCAGLA EEHHHCHHHHHHCCC	24.34	30108239
386	Ubiquitination	VADFGLSKVCAGLAP EHHHCHHHHHHCCCC	46.50	-
410	Phosphorylation	KNVNVNKYWLSSACG CCCCCCHHHHHHHCC	13.33	23090842
413	Phosphorylation	NVNKYWLSSACGSDF CCCHHHHHHHCCCCE	11.18	26074081
414	Phosphorylation	VNKYWLSSACGSDFY CCHHHHHHHCCCCEE	25.96	22777824
418	Phosphorylation	WLSSACGSDFYMAPE HHHHHCCCCEEECHH	25.16	26074081
421	Phosphorylation	SACGSDFYMAPEVWE HHCCCCEEECHHHHC	9.43	23090842
431	Phosphorylation	PEVWEGHYTAKADIF HHHHCCCCCHHHHHH	21.17	23090842
432	Phosphorylation	EVWEGHYTAKADIFA HHHCCCCCHHHHHHH	18.92	23090842
452	O-linked_Glycosylation	WAMIERITFIDSETK HHHHHHHHCCCCCHH	22.28	30620550
458	Phosphorylation	ITFIDSETKKELLGT HHCCCCCHHHHHHHH	51.90	28509920
465	Phosphorylation	TKKELLGTYIKQGTE HHHHHHHHHHHCCCE	23.26	-
468	Ubiquitination	ELLGTYIKQGTEIVP HHHHHHHHCCCEEEE	32.06	29967540
485	Ubiquitination	EALLENPKMELHIPQ HHHHHCCCCCCCCCH	57.50	29967540
496	Phosphorylation	HIPQKRRTSMSEGIK CCCHHHHCCHHHHHH	32.58	-
497	Phosphorylation	IPQKRRTSMSEGIKQ CCHHHHCCHHHHHHH	20.64	23312004
499	Phosphorylation	QKRRTSMSEGIKQLL HHHHCCHHHHHHHHH	32.22	26714015
503	Ubiquitination	TSMSEGIKQLLKDML CCHHHHHHHHHHHHH	45.83	21890473
503	Ubiquitination	TSMSEGIKQLLKDML CCHHHHHHHHHHHHH	45.83	21890473
503	Ubiquitination	TSMSEGIKQLLKDML CCHHHHHHHHHHHHH	45.83	21890473
507	Ubiquitination	EGIKQLLKDMLAANP HHHHHHHHHHHHHCC	50.08	29967540

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of STK35_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of STK35_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of STK35_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PDLI1_HUMAN	PDLIM1	physical	11973348
CTSL2_HUMAN	CTDSPL2	physical	28514442
CD37L_HUMAN	CDC37L1	physical	28514442
CA174_HUMAN	C1orf174	physical	28514442
UBIP1_HUMAN	UBP1	physical	28514442
CDC37_HUMAN	CDC37	physical	28514442
HS90A_HUMAN	HSP90AA1	physical	28514442
HS90B_HUMAN	HSP90AB1	physical	28514442
FKBP5_HUMAN	FKBP5	physical	28514442
TFCP2_HUMAN	TFCP2	physical	28514442
PR14L_HUMAN	PRR14L	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.