dbPTM

STIM2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	STIM2_HUMAN
UniProt AC	Q9P246
Protein Name	Stromal interaction molecule 2
Gene Name	STIM2
Organism	Homo sapiens (Human).
Sequence Length	746
Subcellular Localization	Endoplasmic reticulum membrane Single-pass type I membrane protein . Dynamically translocates from a uniform endoplasmic reticulum distribution to punctual endoplasmic reticulum-plasma membrane junctions in response to decrease in endoplasmic retic
Protein Description	Plays a role in mediating store-operated Ca(2+) entry (SOCE), a Ca(2+) influx following depletion of intracellular Ca(2+) stores. Functions as a highly sensitive Ca(2+) sensor in the endoplasmic reticulum which activates both store-operated and store-independent Ca(2+)-influx. Regulates basal cytosolic and endoplasmic reticulum Ca(2+) concentrations. Upon mild variations of the endoplasmic reticulum Ca(2+) concentration, translocates from the endoplasmic reticulum to the plasma membrane where it probably activates the Ca(2+) release-activated Ca(2+) (CRAC) channels ORAI1, ORAI2 and ORAI3. May inhibit STIM1-mediated Ca(2+) influx..
Protein Sequence	MLVLGLLVAGAADGCELVPRHLRGRRATGSAATAASSPAAAAGDSPALMTDPCMSLSPPCFTEEDRFSLEALQTIHKQMDDDKDGGIEVEESDEFIREDMKYKDATNKHSHLHREDKHITIEDLWKRWKTSEVHNWTLEDTLQWLIEFVELPQYEKNFRDNNVKGTTLPRIAVHEPSFMISQLKISDRSHRQKLQLKALDVVLFGPLTRPPHNWMKDFILTVSIVIGVGGCWFAYTQNKTSKEHVAKMMKDLESLQTAEQSLMDLQERLEKAQEENRNVAVEKQNLERKMMDEINYAKEEACRLRELREGAECELSRRQYAEQELEQVRMALKKAEKEFELRSSWSVPDALQKWLQLTHEVEVQYYNIKRQNAEMQLAIAKDEAEKIKKKRSTVFGTLHVAHSSSLDEVDHKILEAKKALSELTTCLRERLFRWQQIEKICGFQIAHNSGLPSLTSSLYSDHSWVVMPRVSIPPYPIAGGVDDLDEDTPPIVSQFPGTMAKPPGSLARSSSLCRSRRSIVPSSPQPQRAQLAPHAPHPSHPRHPHHPQHTPHSLPSPDPDILSVSSCPALYRNEEEEEAIYFSAEKQWEVPDTASECDSLNSSIGRKQSPPLSLEIYQTLSPRKISRDEVSLEDSSRGDSPVTVDVSWGSPDCVGLTETKSMIFSPASKVYNGILEKSCSMNQLSSGIPVPKPRHTSCSSAGNDSKPVQEAPSVARISSIPHDLCHNGEKSKKPSKIKSLFKKKSK

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
24 (in isoform 2)	Phosphorylation	-	29.77	30257219
28	Phosphorylation	HLRGRRATGSAATAA HHCCCCCCCCCHHHH	29.83	28122231
30	Phosphorylation	RGRRATGSAATAASS CCCCCCCCCHHHHCC	15.46	28122231
33	Phosphorylation	RATGSAATAASSPAA CCCCCCHHHHCCHHH	23.60	28122231
36	Phosphorylation	GSAATAASSPAAAAG CCCHHHHCCHHHHCC	34.10	28122231
37	Phosphorylation	SAATAASSPAAAAGD CCHHHHCCHHHHCCC	17.52	28122231
45	Phosphorylation	PAAAAGDSPALMTDP HHHHCCCCCCCCCCC	15.91	28122231
50	Phosphorylation	GDSPALMTDPCMSLS CCCCCCCCCCCCCCC	37.33	28122231
55	O-linked_Glycosylation	LMTDPCMSLSPPCFT CCCCCCCCCCCCCCC	32.20	OGP
55	Phosphorylation	LMTDPCMSLSPPCFT CCCCCCCCCCCCCCC	32.20	28122231
57	Phosphorylation	TDPCMSLSPPCFTEE CCCCCCCCCCCCCHH	21.35	28122231
62	Phosphorylation	SLSPPCFTEEDRFSL CCCCCCCCHHHHCCH	45.22	28122231
135	N-linked_Glycosylation	WKTSEVHNWTLEDTL HHCCCCCCCCHHHHH	38.31	UniProtKB CARBOHYD
164	Ubiquitination	NFRDNNVKGTTLPRI HCCCCCCCCCCCCEE	53.30	-
181	Phosphorylation	HEPSFMISQLKISDR CCCCCEEEEECCCCC	20.06	24719451
254	Phosphorylation	KMMKDLESLQTAEQS HHHHHHHHHHHHHHH	32.83	29083192
257	Phosphorylation	KDLESLQTAEQSLMD HHHHHHHHHHHHHHH	37.14	29083192
261	Phosphorylation	SLQTAEQSLMDLQER HHHHHHHHHHHHHHH	19.71	26657352
283	Ubiquitination	NRNVAVEKQNLERKM HHHHHHHHHHHHHHH	37.58	2190698
289	Ubiquitination	EKQNLERKMMDEINY HHHHHHHHHHHHHHH	29.24	-
320	Phosphorylation	CELSRRQYAEQELEQ CCHHHHHHHHHHHHH	15.42	20736484
343	Phosphorylation	EKEFELRSSWSVPDA HHHHHHCCCCCCCHH	49.10	28857561
344	Phosphorylation	KEFELRSSWSVPDAL HHHHHCCCCCCCHHH	19.55	28857561
346	Phosphorylation	FELRSSWSVPDALQK HHHCCCCCCCHHHHH	26.22	30576142
370	Ubiquitination	VQYYNIKRQNAEMQL EEEEEHHHCCHHHHH	31.05	21906983
370	Ubiquitination	VQYYNIKRQNAEMQL EEEEEHHHCCHHHHH	31.05	21906983
392	Phosphorylation	EKIKKKRSTVFGTLH HHHHHHHCHHHHHHH	37.49	29449344
393	Phosphorylation	KIKKKRSTVFGTLHV HHHHHHCHHHHHHHH	24.72	29449344
397	Phosphorylation	KRSTVFGTLHVAHSS HHCHHHHHHHHHCCC	11.39	29449344
453	Phosphorylation	AHNSGLPSLTSSLYS HCCCCCCCHHCHHCC	49.69	28348404
455	Phosphorylation	NSGLPSLTSSLYSDH CCCCCCHHCHHCCCC	22.17	28348404
456	Phosphorylation	SGLPSLTSSLYSDHS CCCCCHHCHHCCCCC	24.52	28348404
457	Phosphorylation	GLPSLTSSLYSDHSW CCCCHHCHHCCCCCE	26.54	28348404
460	Phosphorylation	SLTSSLYSDHSWVVM CHHCHHCCCCCEEEE	33.85	28348404
463	Phosphorylation	SSLYSDHSWVVMPRV CHHCCCCCEEEEECC	26.93	24719451
471	Phosphorylation	WVVMPRVSIPPYPIA EEEEECCCCCCCCCC	30.56	24719451
518	Phosphorylation	SLCRSRRSIVPSSPQ HHHHCCCCCCCCCCC	27.16	30266825
522	Phosphorylation	SRRSIVPSSPQPQRA CCCCCCCCCCCCCHH	43.70	30266825
523	Phosphorylation	RRSIVPSSPQPQRAQ CCCCCCCCCCCCHHC	22.83	29255136
526	Phosphorylation	IVPSSPQPQRAQLAP CCCCCCCCCHHCCCC	29.07	24719451
530	Phosphorylation	SPQPQRAQLAPHAPH CCCCCHHCCCCCCCC	40.10	24719451
531	Phosphorylation	PQPQRAQLAPHAPHP CCCCHHCCCCCCCCC	8.59	24719451
539	Phosphorylation	APHAPHPSHPRHPHH CCCCCCCCCCCCCCC	42.99	23312004
556	Phosphorylation	HTPHSLPSPDPDILS CCCCCCCCCCCCCEE	47.42	26657352
563	Phosphorylation	SPDPDILSVSSCPAL CCCCCCEECCCCCCE	21.93	26657352
566	Phosphorylation	PDILSVSSCPALYRN CCCEECCCCCCEECC	23.20	-
581	Phosphorylation	EEEEEAIYFSAEKQW HHHHHHEEEECCCCC	9.87	28796482
583	Phosphorylation	EEEAIYFSAEKQWEV HHHHEEEECCCCCCC	20.67	28796482
593	Phosphorylation	KQWEVPDTASECDSL CCCCCCCCHHHHHHC	26.47	23403867
595	Phosphorylation	WEVPDTASECDSLNS CCCCCCHHHHHHCCC	40.63	23403867
599	Phosphorylation	DTASECDSLNSSIGR CCHHHHHHCCCCCCC	40.90	23403867
602	Phosphorylation	SECDSLNSSIGRKQS HHHHHCCCCCCCCCC	28.73	25159151
603	Phosphorylation	ECDSLNSSIGRKQSP HHHHCCCCCCCCCCC	28.17	23927012
609	Phosphorylation	SSIGRKQSPPLSLEI CCCCCCCCCCCEEEE	31.36	30266825
610	Phosphorylation	SIGRKQSPPLSLEIY CCCCCCCCCCEEEEE	31.21	24719451
611	Phosphorylation	IGRKQSPPLSLEIYQ CCCCCCCCCEEEEEE	39.57	27251275
613	Phosphorylation	RKQSPPLSLEIYQTL CCCCCCCEEEEEECC	29.72	30266825
617	Phosphorylation	PPLSLEIYQTLSPRK CCCEEEEEECCCCCC	6.00	30266825
619	Phosphorylation	LSLEIYQTLSPRKIS CEEEEEECCCCCCCC	16.54	25159151
621	Phosphorylation	LEIYQTLSPRKISRD EEEEECCCCCCCCCC	26.50	25159151
626	Phosphorylation	TLSPRKISRDEVSLE CCCCCCCCCCCCCCC	36.39	23401153
627	Phosphorylation	LSPRKISRDEVSLED CCCCCCCCCCCCCCC	47.81	27251275
629	Phosphorylation	PRKISRDEVSLEDSS CCCCCCCCCCCCCCC	32.66	24719451
631	Phosphorylation	KISRDEVSLEDSSRG CCCCCCCCCCCCCCC	24.80	29255136
634	Phosphorylation	RDEVSLEDSSRGDSP CCCCCCCCCCCCCCC	58.15	24719451
635	Phosphorylation	DEVSLEDSSRGDSPV CCCCCCCCCCCCCCE	16.74	21815630
636	Phosphorylation	EVSLEDSSRGDSPVT CCCCCCCCCCCCCEE	53.24	23927012
639	Phosphorylation	LEDSSRGDSPVTVDV CCCCCCCCCCEEEEE	48.97	24719451
640	Phosphorylation	EDSSRGDSPVTVDVS CCCCCCCCCEEEEEC	24.88	25159151
643	Phosphorylation	SRGDSPVTVDVSWGS CCCCCCEEEEECCCC	17.86	27732954
650	Phosphorylation	TVDVSWGSPDCVGLT EEEECCCCCCCCCCC	16.00	-
659	Phosphorylation	DCVGLTETKSMIFSP CCCCCCCCCCCCCCH	24.16	26074081
661	Phosphorylation	VGLTETKSMIFSPAS CCCCCCCCCCCCHHH	25.24	23401153
665	Phosphorylation	ETKSMIFSPASKVYN CCCCCCCCHHHHHHH	14.50	30266825
668	Phosphorylation	SMIFSPASKVYNGIL CCCCCHHHHHHHHHH	26.49	23403867
669	Phosphorylation	MIFSPASKVYNGILE CCCCHHHHHHHHHHH	51.34	27251275
671	Phosphorylation	FSPASKVYNGILEKS CCHHHHHHHHHHHHC	16.06	26074081
678	Phosphorylation	YNGILEKSCSMNQLS HHHHHHHCCCHHHHC	11.31	23927012
680	Phosphorylation	GILEKSCSMNQLSSG HHHHHCCCHHHHCCC	28.05	25159151
685	Phosphorylation	SCSMNQLSSGIPVPK CCCHHHHCCCCCCCC	19.43	23927012
686	Phosphorylation	CSMNQLSSGIPVPKP CCHHHHCCCCCCCCC	49.70	23927012
688	Phosphorylation	MNQLSSGIPVPKPRH HHHHCCCCCCCCCCC	3.16	24719451
696	Phosphorylation	PVPKPRHTSCSSAGN CCCCCCCCCCCCCCC	32.48	22617229
697	Phosphorylation	VPKPRHTSCSSAGND CCCCCCCCCCCCCCC	13.08	23401153
699	Phosphorylation	KPRHTSCSSAGNDSK CCCCCCCCCCCCCCC	24.00	25159151
700	Phosphorylation	PRHTSCSSAGNDSKP CCCCCCCCCCCCCCC	44.52	23911959
704	Phosphorylation	SCSSAGNDSKPVQEA CCCCCCCCCCCCCCC	58.06	24719451
705	Phosphorylation	CSSAGNDSKPVQEAP CCCCCCCCCCCCCCC	42.74	23663014
707	Phosphorylation	SAGNDSKPVQEAPSV CCCCCCCCCCCCCCE	36.66	24719451
708	Phosphorylation	AGNDSKPVQEAPSVA CCCCCCCCCCCCCEE	10.37	27251275
713	Phosphorylation	KPVQEAPSVARISSI CCCCCCCCEEEHHHC	35.14	26552605
718	Phosphorylation	APSVARISSIPHDLC CCCEEEHHHCCCHHC	19.36	23401153
719	Phosphorylation	PSVARISSIPHDLCH CCEEEHHHCCCHHCC	37.45	23401153
726	Phosphorylation	SIPHDLCHNGEKSKK HCCCHHCCCCCCCCC	53.26	24719451
739	Phosphorylation	KKPSKIKSLFKKKSK CCHHHHHHHHHHCCC	42.38	24719451
742	Methylation	SKIKSLFKKKSK--- HHHHHHHHHCCC---	65.66	-
747	Phosphorylation	LFKKKSK-------- HHHHCCC--------		24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of STIM2_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of STIM2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of STIM2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
STIM1_HUMAN	STIM1	physical	11463338
STIM1_HUMAN	STIM1	physical	28514442
BRNP3_HUMAN	BRINP3	physical	28514442
AAPK1_HUMAN	PRKAA1	physical	28514442
AAKG2_HUMAN	PRKAG2	physical	28514442
AAKG1_HUMAN	PRKAG1	physical	28514442
AAKB1_HUMAN	PRKAB1	physical	28514442
AAKB2_HUMAN	PRKAB2	physical	28514442
AAPK2_HUMAN	PRKAA2	physical	28514442
MSRB3_HUMAN	MSRB3	physical	28514442
SUMF1_HUMAN	SUMF1	physical	28514442
CISD2_HUMAN	CISD2	physical	28514442
TMLH_HUMAN	TMLHE	physical	28514442
HMOX1_HUMAN	HMOX1	physical	28514442

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of STIM2_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-609; SER-621; SER-661AND SER-680, AND MASS SPECTROMETRY.	18669648 [Abstract]