STAT6_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: STAT6_MOUSE
• UniProt AC: P52633
• Protein Name: Signal transducer and transcription activator 6
• Gene Name: Stat6
• Organism: Mus musculus (Mouse).
• Sequence Length: 837
• Subcellular Localization: Cytoplasm. Nucleus. Translocated into the nucleus in response to phosphorylation.
• Protein Description: Carries out a dual signal transduction and activation of transcription. Involved in IL4/interleukin-4- and IL3/interleukin-3-mediated signaling..
• Protein Sequence: MSLWGLISKMSPEKLQRLYVDFPQRLRHLLADWLESQPWEFLVGSDAFCYNMASALLSATVQRLQATAGEQGKGNSILPHISTLESIYQRDPLKLVATIRQILQGEKKAVIEEFRHLPGPFHRKQEELKFTTALGRLQHRVRETRLLRESLQQGAKTGQVSLQNLIDPPVNGPGPSEDLATMLQGTVGDLEATQALVLKRIQIWKRQQQLAGNGTPFEESLAGLQERCESLVEIYSQLQQEIGAASGELEPKTRASLISRLDEVLRTLVTSSFLVEKQPPQVLKTQTKFQAGVRFLLGLQFLGTSAKPPMVRADMVTEKQARELSLAQGPGTGVESTGEIMNNTVPLENSIPSNCCSALFKNLLLKKIKRCERKGTESVTEEKCAVLFSTSFTLGPNKLLIQLQALSLPLVVIVHGNQDNNAKATILWDNAFSEMDRVPFVVAERVPWEKMCETLNLKFMAEVGTSRGLLPEHFLFLAQKIFNDNSLSVEAFQHRCVSWSQFNKEILLGRGFTFWQWFDGVLDLTKRCLRSYWSDRLIIGFISKQYVTSLLLNEPDGTFLLRFSDSEIGGITIAHVIRGQDGSSQIENIQPFSAKDLSIRSLGDRIRDLAQLKNLYPKKPKDEAFRSHYKPEQMGKDGRGYVSTTIKMTVERDQPLPTPEPQMPAMVPPYDLGMAPDASMQLSSDMGYPPQSIHSFQSLEESMSVLPSFQEPHLQMPPNMSQITMPFDQPHPQGLLQCQSQEHAVSSPEPMLCSDVTMVEDSCLTQPVGGFPQGTWVSEDMYPPLMPPTEQDLTKLLLENQGEAGGSLGSQPLLQPSPYGQSGISLSHLDLRTNPSW

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MSLWGLISK ------CCHHHHHHH	32.59	-
8	Phosphorylation	MSLWGLISKMSPEKL CCHHHHHHHCCHHHH	27.61	26643407
11	Phosphorylation	WGLISKMSPEKLQRL HHHHHHCCHHHHHHH	33.37	26643407
27	Methylation	VDFPQRLRHLLADWL CCHHHHHHHHHHHHH	22.16	8516401
94	Ubiquitination	IYQRDPLKLVATIRQ HHHCCHHHHHHHHHH	46.43	22790023
129	Acetylation	HRKQEELKFTTALGR CCCHHHHHHHHHHHH	43.90	6566289
277	Ubiquitination	TSSFLVEKQPPQVLK HHHHHCCCCCCCCCC	61.70	22790023
376	Phosphorylation	KRCERKGTESVTEEK HHHHHCCCCCCCHHH	28.28	28576409
558	Phosphorylation	LLNEPDGTFLLRFSD HHCCCCCEEEEEEEC	20.63	22871156
595	Ubiquitination	NIQPFSAKDLSIRSL CCCCCCHHHCCHHHH	58.99	22790023
619	Acetylation	LKNLYPKKPKDEAFR HHHHCCCCCCCHHHH	53.44	19850915
621	Acetylation	NLYPKKPKDEAFRSH HHCCCCCCCHHHHHH	76.66	19850925
641	Phosphorylation	MGKDGRGYVSTTIKM CCCCCCCEEEEEEEE	7.00	12244176
643	Phosphorylation	KDGRGYVSTTIKMTV CCCCCEEEEEEEEEE	16.02	25367039
807	Phosphorylation	NQGEAGGSLGSQPLL HCCCCCCCCCCCCCC	28.74	23984901
810	Phosphorylation	EAGGSLGSQPLLQPS CCCCCCCCCCCCCCC	33.64	23984901
817	Phosphorylation	SQPLLQPSPYGQSGI CCCCCCCCCCCCCCC	20.14	23984901
819	Phosphorylation	PLLQPSPYGQSGISL CCCCCCCCCCCCCCC	31.94	23984901
822	Phosphorylation	QPSPYGQSGISLSHL CCCCCCCCCCCCHHC	33.46	23984901
825	Phosphorylation	PYGQSGISLSHLDLR CCCCCCCCCHHCCCC	27.61	23984901
827	Phosphorylation	GQSGISLSHLDLRTN CCCCCCCHHCCCCCC	18.40	23984901

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
641	Y	Phosphorylation	Kinase	JAK	-	Uniprot

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of STAT6_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of STAT6_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
STAT6_MOUSE	Stat6	physical	20211142
PAR14_MOUSE	Parp14	physical	16537510
LITAF_MOUSE	Litaf	physical	15793005
RN128_MOUSE	Rnf128	physical	25145352

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.