SPY1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SPY1_MOUSE
• UniProt AC: Q9QXV9
• Protein Name: Protein sprouty homolog 1
• Gene Name: Spry1
• Organism: Mus musculus (Mouse).
• Sequence Length: 313
• Subcellular Localization: Cytoplasm. Membrane; Peripheral membrane protein. Found in the cytoplasm in unstimulated cells but is translocated to the membrane ruffles in cells stimulated with EGF (epidermal growth factor).
• Protein Description: May function as an antagonist of fibroblast growth factor (FGF) pathways and may negatively modulate respiratory organogenesis..
• Protein Sequence: MDSPSQHGSHTSLVVIQPPAVEGRQRLDYDRDTQPATILSLDQIKAIRGSNEYTEGPSVARRPAPRTAPRPEKQERTHEIIPANVNSSYEHRPASHPGNARGSVLSRSTSTGSAASSGSSSSVSSEQGLLGRSPPTRPIPGHRSDRVIRTQPKQLLVEDLKASLKEDPTQHKFICEQCGKCKCGECTAPRALPSCLACDRQCLCSAESMVEYGTCMCLVKGIFYHCSNDDDGGSYSDNPCSCSQSHCCSRYLCMGALSLCLPCLLCYPPAKGCLKLCRGCYDWTHRPGCRCRNSNTVYCKLESCPSRAQGKLS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MDSPSQHG -------CCCCCCCC	11.83	-
3	Phosphorylation	-----MDSPSQHGSH -----CCCCCCCCCC	25.75	29472430
5	Phosphorylation	---MDSPSQHGSHTS ---CCCCCCCCCCCE	38.47	23984901
9	Phosphorylation	DSPSQHGSHTSLVVI CCCCCCCCCCEEEEE	22.82	23984901
11	Phosphorylation	PSQHGSHTSLVVIQP CCCCCCCCEEEEECC	26.00	23984901
12	Phosphorylation	SQHGSHTSLVVIQPP CCCCCCCEEEEECCC	17.47	29472430
29	Phosphorylation	EGRQRLDYDRDTQPA CCCCCCCCCCCCCCC	19.92	29514104
40	Phosphorylation	TQPATILSLDQIKAI CCCCEEEEHHHHHHH	26.50	-
50	Phosphorylation	QIKAIRGSNEYTEGP HHHHHCCCCCCCCCC	19.35	26239621
53	Phosphorylation	AIRGSNEYTEGPSVA HHCCCCCCCCCCCCC	17.84	22817900
89	Phosphorylation	PANVNSSYEHRPASH CCCCCCCCCCCCCCC	18.64	29514104
133	Phosphorylation	EQGLLGRSPPTRPIP CCCCCCCCCCCCCCC	33.17	22817900
161	Ubiquitination	QLLVEDLKASLKEDP CHHHHHHHHHHCCCC	48.53	-
163	Phosphorylation	LVEDLKASLKEDPTQ HHHHHHHHHCCCCCC	38.08	25338131
298	Phosphorylation	CRNSNTVYCKLESCP CCCCCCEEEEECCCC	5.05	29514104

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SPY1_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SPY1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SPY1_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SIAH2_MOUSE	Siah2	physical	16888801
SPY1_MOUSE	Spry1	physical	16339969
SPY2_MOUSE	Spry2	physical	16339969
SPY4_MOUSE	Spry4	physical	16339969
GRB2_MOUSE	Grb2	physical	16339969

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.