SMRP1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SMRP1_HUMAN
• UniProt AC: Q8NCR6
• Protein Name: Spermatid-specific manchette-related protein 1
• Gene Name: SMRP1
• Organism: Homo sapiens (Human).
• Sequence Length: 262
• Subcellular Localization: Cytoplasm, cytoskeleton. Nucleus . Cytoplasm . Localizes to the manchette in elongating spermatids (By similarity). Predominantly perinuclear in bronchial epithelial cells but also detected in the nucleus in some primary epithelial cells and in a num
• Protein Description: May play a role in spermatogenesis (By similarity). May be involved in differentiation or function of ciliated cells..
• Protein Sequence: MFLFSRKTRTPISTYSDSYRAPTSIKEVYKDPPLCAWEANKFLTPGLTHTMERHVDPEALQKMAKCAVQDYTYRGSISGHPYLPEKYWLSQEEADKCSPNYLGSDWYNTWRMEPYNSSCCNKYTTYLPRLPKEARMETAVRGMPLECPPRPERLNAYEREVMVNMLNSLSRNQQLPRITPRCGCVDPLPGRLPFHGYESACSGRHYCLRGMDYYASGAPCTDRRLRPWCREQPTMCTSLRAPARNAVCCYNSPAVILPISEP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
18	Phosphorylation	PISTYSDSYRAPTSI CCCCCCCCCCCCCCH	15.58	-
23	Phosphorylation	SDSYRAPTSIKEVYK CCCCCCCCCHHHHHC	41.94	25693802
24	Phosphorylation	DSYRAPTSIKEVYKD CCCCCCCCHHHHHCC	30.51	25693802
29	Phosphorylation	PTSIKEVYKDPPLCA CCCHHHHHCCCCCHH	15.68	25693802
30	Acetylation	TSIKEVYKDPPLCAW CCHHHHHCCCCCHHH	69.78	25038526
69 (in isoform 3)	Phosphorylation	-	21.33	27732954
70 (in isoform 3)	Phosphorylation	-	31.01	27732954
71 (in isoform 3)	Phosphorylation	-	6.65	27732954
71	Phosphorylation	AKCAVQDYTYRGSIS HHHHCCCCCCCCCCC	6.65	25693802
72	Phosphorylation	KCAVQDYTYRGSISG HHHCCCCCCCCCCCC	18.29	25693802
73	Phosphorylation	CAVQDYTYRGSISGH HHCCCCCCCCCCCCC	13.52	25693802
73 (in isoform 3)	Phosphorylation	-	13.52	27732954
76	Phosphorylation	QDYTYRGSISGHPYL CCCCCCCCCCCCCCC	12.46	25693802
86	Acetylation	GHPYLPEKYWLSQEE CCCCCCHHEECCHHH	39.52	25038526
90	Phosphorylation	LPEKYWLSQEEADKC CCHHEECCHHHHHHC	22.77	30622161
96	Acetylation	LSQEEADKCSPNYLG CCHHHHHHCCCCCCC	43.59	25038526
98	Phosphorylation	QEEADKCSPNYLGSD HHHHHHCCCCCCCCC	23.17	30622161
101	Phosphorylation	ADKCSPNYLGSDWYN HHHCCCCCCCCCCCC	18.80	30622161
104	Phosphorylation	CSPNYLGSDWYNTWR CCCCCCCCCCCCCCC	23.52	30622161
109	Phosphorylation	LGSDWYNTWRMEPYN CCCCCCCCCCCCCCC	9.96	30622161
115	Phosphorylation	NTWRMEPYNSSCCNK CCCCCCCCCCCCCCC	17.86	30622161
117	Phosphorylation	WRMEPYNSSCCNKYT CCCCCCCCCCCCCCH	20.93	30622161
118	Phosphorylation	RMEPYNSSCCNKYTT CCCCCCCCCCCCCHH	21.03	30622161
122 (in isoform 4)	Phosphorylation	-	30.02	27732954
122	Acetylation	YNSSCCNKYTTYLPR CCCCCCCCCHHCCCC	30.02	25038526
123 (in isoform 4)	Phosphorylation	-	7.13	27732954
123	Phosphorylation	NSSCCNKYTTYLPRL CCCCCCCCHHCCCCC	7.13	24719451
124 (in isoform 4)	Phosphorylation	-	15.58	27732954
124	Phosphorylation	SSCCNKYTTYLPRLP CCCCCCCHHCCCCCC	15.58	24719451
125	Phosphorylation	SCCNKYTTYLPRLPK CCCCCCHHCCCCCCH	21.70	24719451
126 (in isoform 4)	Phosphorylation	-	13.60	27732954
126	Phosphorylation	CCNKYTTYLPRLPKE CCCCCHHCCCCCCHH	13.60	-
150	Methylation	MPLECPPRPERLNAY CCCCCCCCHHHCCHH	30.74	-
153	Methylation	ECPPRPERLNAYERE CCCCCHHHCCHHHHH	35.61	-
168	Phosphorylation	VMVNMLNSLSRNQQL HHHHHHHHHCCCCCC	24.62	25693802
170	Phosphorylation	VNMLNSLSRNQQLPR HHHHHHHCCCCCCCC	29.07	25693802
238	Phosphorylation	EQPTMCTSLRAPARN CCCCCCCCCCCCCCC	15.78	30631047

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SMRP1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SMRP1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SMRP1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NIF3L_HUMAN	NIF3L1	physical	26186194
TCPW_HUMAN	CCT6B	physical	26186194
UBAC1_HUMAN	UBAC1	physical	26186194
MMAD_HUMAN	MMADHC	physical	26186194
HECD1_HUMAN	HECTD1	physical	26186194
NAGK_HUMAN	NAGK	physical	26186194
DCTN6_HUMAN	DCTN6	physical	26186194
ARP10_HUMAN	ACTR10	physical	26186194
PSMF1_HUMAN	PSMF1	physical	26186194
MMAD_HUMAN	MMADHC	physical	28514442
PSMF1_HUMAN	PSMF1	physical	28514442
NIF3L_HUMAN	NIF3L1	physical	28514442
DCTN6_HUMAN	DCTN6	physical	28514442
LONM_HUMAN	LONP1	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.