SMOX_HUMAN - dbPTM
SMOX_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID SMOX_HUMAN
UniProt AC Q9NWM0
Protein Name Spermine oxidase
Gene Name SMOX
Organism Homo sapiens (Human).
Sequence Length 555
Subcellular Localization Isoform 1: Cytoplasm. Nucleus.
Isoform 4: Cytoplasm. Nucleus.
Isoform 6: Cytoplasm. Nucleus.
Protein Description Flavoenzyme which catalyzes the oxidation of spermine to spermidine. Can also use N(1)-acetylspermine and spermidine as substrates, with different affinity depending on the isoform (isozyme) and on the experimental conditions. Plays an important role in the regulation of polyamine intracellular concentration and has the potential to act as a determinant of cellular sensitivity to the antitumor polyamine analogs. May contribute to beta-alanine production via aldehyde dehydrogenase conversion of 3-amino-propanal..
Protein Sequence MQSCESSGDSADDPLSRGLRRRGQPRVVVIGAGLAGLAAAKALLEQGFTDVTVLEASSHIGGRVQSVKLGHATFELGATWIHGSHGNPIYHLAEANGLLEETTDGERSVGRISLYSKNGVACYLTNHGRRIPKDVVEEFSDLYNEVYNLTQEFFRHDKPVNAESQNSVGVFTREEVRNRIRNDPDDPEATKRLKLAMIQQYLKVESCESSSHSMDEVSLSAFGEWTEIPGAHHIIPSGFMRVVELLAEGIPAHVIQLGKPVRCIHWDQASARPRGPEIEPRGEGDHNHDTGEGGQGGEEPRGGRWDEDEQWSVVVECEDCELIPADHVIVTVSLGVLKRQYTSFFRPGLPTEKVAAIHRLGIGTTDKIFLEFEEPFWGPECNSLQFVWEDEAESHTLTYPPELWYRKICGFDVLYPPERYGHVLSGWICGEEALVMEKCDDEAVAEICTEMLRQFTGNPNIPKPRRILRSAWGSNPYFRGSYSYTQVGSSGADVEKLAKPLPYTESSKTAPMQVLFSGEATHRKYYSTTHGALLSGQREAARLIEMYRDLFQQGT
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
3Phosphorylation-----MQSCESSGDS
-----CCCCCCCCCC		20.6722964224
6Phosphorylation--MQSCESSGDSADD
--CCCCCCCCCCCCC		43.9022964224
7Phosphorylation-MQSCESSGDSADDP
-CCCCCCCCCCCCCH		25.0722964224
10PhosphorylationSCESSGDSADDPLSR
CCCCCCCCCCCHHHH		36.8022964224
16PhosphorylationDSADDPLSRGLRRRG
CCCCCHHHHHHHHCC		29.6822210691
113PhosphorylationERSVGRISLYSKNGV
CCEEEEEEEEECCCE		21.64-
115PhosphorylationSVGRISLYSKNGVAC
EEEEEEEEECCCEEE		15.7126126808
116PhosphorylationVGRISLYSKNGVACY
EEEEEEEECCCEEEE		25.5726126808
152 (in isoform 3)Phosphorylation-41.33-
158UbiquitinationQEFFRHDKPVNAESQ
HHHHHCCCCCCCCCC		44.7533845483
159UbiquitinationEFFRHDKPVNAESQN
HHHHCCCCCCCCCCC		30.5627667366
191 (in isoform 5)Ubiquitination-63.8821906983
191 (in isoform 2)Ubiquitination-63.8821906983
191 (in isoform 1)Ubiquitination-63.8821906983
191 (in isoform 4)Ubiquitination-63.8821906983
191UbiquitinationPDDPEATKRLKLAMI
CCCHHHHHHHHHHHH		63.8821906983
194UbiquitinationPEATKRLKLAMIQQY
HHHHHHHHHHHHHHH		37.9322817900
201PhosphorylationKLAMIQQYLKVESCE
HHHHHHHHHCHHCCC		7.6619664995
259 (in isoform 2)Ubiquitination-49.2721906983
259 (in isoform 5)Ubiquitination-49.2721906983
259 (in isoform 1)Ubiquitination-49.2721906983
259 (in isoform 6)Ubiquitination-49.27-
259 (in isoform 4)Ubiquitination-49.2721906983
259UbiquitinationAHVIQLGKPVRCIHW
CEEEECCCCEEEEEC		49.2722817900
343PhosphorylationVLKRQYTSFFRPGLP
HHHHCCCCCCCCCCC		19.9024719451
407UbiquitinationPPELWYRKICGFDVL
CHHHHHHHHCCCEEE		27.01-
407 (in isoform 6)Ubiquitination-27.01-
443UbiquitinationMEKCDDEAVAEICTE
EECCCHHHHHHHHHH		16.8922817900
446UbiquitinationCDDEAVAEICTEMLR
CCHHHHHHHHHHHHH		31.8122817900
446 (in isoform 2)Ubiquitination-31.8121906983
446 (in isoform 4)Ubiquitination-31.8121906983
455UbiquitinationCTEMLRQFTGNPNIP
HHHHHHHHHCCCCCC		8.3633845483
471UbiquitinationPRRILRSAWGSNPYF
CHHHHHHHCCCCCCC		14.2827667366
496UbiquitinationSSGADVEKLAKPLPY
CCCCCHHHHCCCCCC		54.3022817900
499 (in isoform 1)Ubiquitination-58.4821906983
499UbiquitinationADVEKLAKPLPYTES
CCHHHHCCCCCCCCC		58.4822817900
499 (in isoform 5)Ubiquitination-58.4821906983
501UbiquitinationVEKLAKPLPYTESSK
HHHHCCCCCCCCCCC		5.0927667366
508UbiquitinationLPYTESSKTAPMQVL
CCCCCCCCCCCEEEE		58.9733845483
524UbiquitinationSGEATHRKYYSTTHG
CCCCCCCEEEECHHC		40.7227667366
554UbiquitinationYRDLFQQGT------
HHHHHHHCC------		23.7027667366
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of SMOX_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of SMOX_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of SMOX_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
AL1A3_HUMANALDH1A3physical
28514442
TCPW_HUMANCCT6Bphysical
28514442
HERC1_HUMANHERC1physical
28514442
TCPG_HUMANCCT3physical
28514442
TCPB_HUMANCCT2physical
28514442
FLNC_HUMANFLNCphysical
28514442
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
DB00127Spermine
Regulatory Network of SMOX_HUMAN

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Related Literatures of Post-Translational Modification

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