SIG12_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SIG12_HUMAN
• UniProt AC: Q96PQ1
• Protein Name: Sialic acid-binding Ig-like lectin 12
• Gene Name: SIGLEC12
• Organism: Homo sapiens (Human).
• Sequence Length: 595
• Subcellular Localization: Membrane; Single-pass type I membrane protein.
• Protein Description: Putative adhesion molecule that mediates sialic-acid dependent binding to cells. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface..
• Protein Sequence: MLLLLLLLPPLLCGRVGAKEQKDYLLTMQKSVTVQEGLCVSVLCSFSYPQNGWTASDPVHGYWFRAGDHVSRNIPVATNNPARAVQEETRDRFHLLGDPQNKDCTLSIRDTRESDAGTYVFCVERGNMKWNYKYDQLSVNVTASQDLLSRYRLEVPESVTVQEGLCVSVPCSVLYPHYNWTASSPVYGSWFKEGADIPWDIPVATNTPSGKVQEDTHGRFLLLGDPQTNNCSLSIRDARKGDSGKYYFQVERGSRKWNYIYDKLSVHVTALTHMPTFSIPGTLESGHPRNLTCSVPWACEQGTPPTITWMGASVSSLDPTITRSSMLSLIPQPQDHGTSLTCQVTLPGAGVTMTRAVRLNISYPPQNLTMTVFQGDGTASTTLRNGSALSVLEGQSLHLVCAVDSNPPARLSWTWGSLTLSPSQSSNLGVLELPRVHVKDEGEFTCRAQNPLGSQHISLSLSLQNEYTGKMRPISGVTLGAFGGAGATALVFLYFCIIFVVVRSCRKKSARPAVGVGDTGMEDANAVRGSASQGPLIESPADDSPPHHAPPALATPSPEEGEIQYASLSFHKARPQYPQEQEAIGYEYSEINIPK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
24 (in isoform 2)	Phosphorylation	-	15.62	-
107	Phosphorylation	QNKDCTLSIRDTRES CCCCCEEEEEECCHH	9.45	24719451
140	N-linked_Glycosylation	KYDQLSVNVTASQDL EEEEEEEEEEECHHH	23.26	UniProtKB CARBOHYD
140	N-linked_Glycosylation	KYDQLSVNVTASQDL EEEEEEEEEEECHHH	23.26	11328818
179	N-linked_Glycosylation	SVLYPHYNWTASSPV CEEECCCCCCCCCCC	26.96	UniProtKB CARBOHYD
179	N-linked_Glycosylation	SVLYPHYNWTASSPV CEEECCCCCCCCCCC	26.96	11328818
216	Phosphorylation	SGKVQEDTHGRFLLL CCCEEECCCCCEEEE	26.02	18452278
228	Phosphorylation	LLLGDPQTNNCSLSI EEECCCCCCCCEEEE	33.51	18452278
230	N-linked_Glycosylation	LGDPQTNNCSLSIRD ECCCCCCCCEEEEEE	21.83	UniProtKB CARBOHYD
230	N-linked_Glycosylation	LGDPQTNNCSLSIRD ECCCCCCCCEEEEEE	21.83	11328818
232	Phosphorylation	DPQTNNCSLSIRDAR CCCCCCCEEEEEECC	27.55	24719451
234	Phosphorylation	QTNNCSLSIRDARKG CCCCCEEEEEECCCC	10.17	24719451
290	N-linked_Glycosylation	LESGHPRNLTCSVPW CCCCCCCCCEEECCC	44.12	UniProtKB CARBOHYD
360	N-linked_Glycosylation	MTRAVRLNISYPPQN EEEEEEEEEECCCCC	15.59	UniProtKB CARBOHYD
360	N-linked_Glycosylation	MTRAVRLNISYPPQN EEEEEEEEEECCCCC	15.59	11328818
367	N-linked_Glycosylation	NISYPPQNLTMTVFQ EEECCCCCEEEEEEE	43.16	UniProtKB CARBOHYD
367	N-linked_Glycosylation	NISYPPQNLTMTVFQ EEECCCCCEEEEEEE	43.16	11328818
385	N-linked_Glycosylation	TASTTLRNGSALSVL CEEEEEECCCEEEEE	52.46	UniProtKB CARBOHYD
385	N-linked_Glycosylation	TASTTLRNGSALSVL CEEEEEECCCEEEEE	52.46	11328818
475	Phosphorylation	TGKMRPISGVTLGAF CCCEEECCCEEEECC	29.87	-
478	Phosphorylation	MRPISGVTLGAFGGA EEECCCEEEECCCHH	24.01	-
488	Phosphorylation	AFGGAGATALVFLYF CCCHHHHHHHHHHHH	21.43	-
494	Phosphorylation	ATALVFLYFCIIFVV HHHHHHHHHHHHHHH	5.73	-
509	Phosphorylation	VRSCRKKSARPAVGV HHHHCCCCCCCCCCC	32.33	22210691
565	Phosphorylation	PEEGEIQYASLSFHK CCCCCCEEEEEEEEE	12.10	-
586	Phosphorylation	QEQEAIGYEYSEINI HHHHHCCCCCCCCCC	12.94	29978859
588	Phosphorylation	QEAIGYEYSEINIPK HHHCCCCCCCCCCCC	11.79	29978859
589	Phosphorylation	EAIGYEYSEINIPK- HHCCCCCCCCCCCC-	21.76	29978859

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SIG12_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SIG12_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SIG12_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TX261_HUMAN	TEX261	physical	28514442
PLAP_HUMAN	PLAA	physical	28514442
S39AB_HUMAN	SLC39A11	physical	28514442
GCP3_HUMAN	TUBGCP3	physical	28514442
GRP78_HUMAN	HSPA5	physical	28514442
UFSP2_HUMAN	UFSP2	physical	28514442
MTX1_HUMAN	MTX1	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.