SHD_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SHD_HUMAN
• UniProt AC: Q96IW2
• Protein Name: SH2 domain-containing adapter protein D
• Gene Name: SHD
• Organism: Homo sapiens (Human).
• Sequence Length: 340
• Protein Description: May function as an adapter protein..
• Protein Sequence: MAKWLRDYLSFGGRRPPPQPPTPDYTESDILRAYRAQKNLDFEDPYEDAESRLEPDPAGPGDSKNPGDAKYGSPKHRLIKVEAADMARAKALLGGPGEELEADTEYLDPFDAQPHPAPPDDGYMEPYDAQWVMSELPGRGVQLYDTPYEEQDPETADGPPSGQKPRQSRMPQEDERPADEYDQPWEWKKDHISRAFAVQFDSPEWERTPGSAKELRRPPPRSPQPAERVDPALPLEKQPWFHGPLNRADAESLLSLCKEGSYLVRLSETNPQDCSLSLRSSQGFLHLKFARTRENQVVLGQHSGPFPSVPELVLHYSSRPLPVQGAEHLALLYPVVTQTP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
22	Phosphorylation	RPPPQPPTPDYTESD CCCCCCCCCCCCHHH	35.16	27732954
46	Phosphorylation	NLDFEDPYEDAESRL CCCCCCCCCCHHHHC	38.47	25884760
51	Phosphorylation	DPYEDAESRLEPDPA CCCCCHHHHCCCCCC	43.84	27732954
73	Phosphorylation	PGDAKYGSPKHRLIK CCCCCCCCCCCCEEE	27.90	25954137
144	Phosphorylation	PGRGVQLYDTPYEEQ CCCCEEEECCCCHHC	10.73	25884760
155	Phosphorylation	YEEQDPETADGPPSG CHHCCCCCCCCCCCC	35.12	27732954
161	Phosphorylation	ETADGPPSGQKPRQS CCCCCCCCCCCCCCC	57.92	27732954
202	Phosphorylation	AFAVQFDSPEWERTP EEEEECCCCCCCCCC	26.47	27732954
222	Phosphorylation	LRRPPPRSPQPAERV HCCCCCCCCCCHHHC	33.39	21552520
275	Phosphorylation	ETNPQDCSLSLRSSQ CCCCCCCEEEEECCC	29.32	17081983
277	Phosphorylation	NPQDCSLSLRSSQGF CCCCCEEEEECCCCE	12.87	17081983
318	Phosphorylation	ELVLHYSSRPLPVQG CEEEECCCCCCCCCC	30.65	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SHD_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SHD_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SHD_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CAN10_HUMAN	CAPN10	physical	25814554
PSG11_HUMAN	PSG11	physical	25814554
KTAP2_HUMAN	KRTCAP2	physical	25814554
OLIG1_HUMAN	OLIG1	physical	25814554
OSBL6_HUMAN	OSBPL6	physical	25814554
BECN1_HUMAN	BECN1	physical	25814554
RT22_HUMAN	MRPS22	physical	25814554

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.