| UniProt ID | CAN10_HUMAN | |
|---|---|---|
| UniProt AC | Q9HC96 | |
| Protein Name | Calpain-10 | |
| Gene Name | CAPN10 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 672 | |
| Subcellular Localization | ||
| Protein Description | Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. May play a role in insulin-stimulated glucose uptake.. | |
| Protein Sequence | MRAGRGATPARELFRDAAFPAADSSLFCDLSTPLAQFREDITWRRPQEICATPRLFPDDPREGQVKQGLLGDCWFLCACAALQKSRHLLDQVIPPGQPSWADQEYRGSFTCRIWQFGRWVEVTTDDRLPCLAGRLCFSRCQREDVFWLPLLEKVYAKVHGSYEHLWAGQVADALVDLTGGLAERWNLKGVAGSGGQQDRPGRWEHRTCRQLLHLKDQCLISCCVLSPRAGARELGEFHAFIVSDLRELQGQAGQCILLLRIQNPWGRRCWQGLWREGGEGWSQVDAAVASELLSQLQEGEFWVEEEEFLREFDELTVGYPVTEAGHLQSLYTERLLCHTRALPGAWVKGQSAGGCRNNSGFPSNPKFWLRVSEPSEVYIAVLQRSRLHAADWAGRARALVGDSHTSWSPASIPGKHYQAVGLHLWKVEKRRVNLPRVLSMPPVAGTACHAYDREVHLRCELSPGYYLAVPSTFLKDAPGEFLLRVFSTGRVSLSAIRAVAKNTTPGAALPAGEWGTVQLRGSWRVGQTAGGSRNFASYPTNPCFPFSVPEGPGPRCVRITLHQHCRPSDTEFHPIGFHIFQVPEGGRSQDAPPLLLQEPLLSCVPHRYAQEVSRLCLLPAGTYKVVPSTYLPDTEGAFTVTIATRIDRPSIHSQEMLGQFLQEVSIMAVMKT | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 138 | Phosphorylation | LAGRLCFSRCQREDV HHHHHHHHHCCCCCC | 31.02 | 24719451 | |
| 188 | Ubiquitination | LAERWNLKGVAGSGG HHHHCCCCCCCCCCC | 48.39 | - | |
| 348 | Ubiquitination | ALPGAWVKGQSAGGC CCCCCEECCCCCCCC | 40.30 | - | |
| 351 | Phosphorylation | GAWVKGQSAGGCRNN CCEECCCCCCCCCCC | 37.23 | 24719451 | |
| 359 | Phosphorylation | AGGCRNNSGFPSNPK CCCCCCCCCCCCCCC | 45.41 | 24719451 | |
| 465 | Phosphorylation | RCELSPGYYLAVPST EEEECCCEEEEEECH | 9.93 | - | |
| 466 | Phosphorylation | CELSPGYYLAVPSTF EEECCCEEEEEECHH | 8.29 | - | |
| 501 | Ubiquitination | SAIRAVAKNTTPGAA HHHHHHHHCCCCCCC | 48.50 | - | |
| 503 (in isoform 4) | Phosphorylation | - | 33.39 | 26552605 | |
| 511 (in isoform 4) | Phosphorylation | - | 29.41 | 26552605 | |
| 534 (in isoform 2) | Phosphorylation | - | 38.23 | 26552605 | |
| 542 (in isoform 2) | Phosphorylation | - | 24.49 | 26552605 | |
| 623 | Phosphorylation | CLLPAGTYKVVPSTY CEECCCCEEEECCCC | 10.81 | 22210691 | |
| 629 | Phosphorylation | TYKVVPSTYLPDTEG CEEEECCCCCCCCCC | 24.02 | 22210691 | |
| 630 | Phosphorylation | YKVVPSTYLPDTEGA EEEECCCCCCCCCCE | 22.15 | 22210691 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of CAN10_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of CAN10_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of CAN10_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| PSA7_HUMAN | PSMA7 | physical | 21988832 | |
| EFNB1_HUMAN | EFNB1 | physical | 21988832 | |
| FANCC_HUMAN | FANCC | physical | 21988832 | |
| FLOT1_HUMAN | FLOT1 | physical | 21988832 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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