SEUSS_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SEUSS_ARATH
• UniProt AC: Q8W234
• Protein Name: Transcriptional corepressor SEUSS
• Gene Name: SEU
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 877
• Subcellular Localization: Nucleus, nucleoplasm . Does not localize in the nucleolus.
• Protein Description: DNA-binding adapter subunit of the SEU-LUG transcriptional corepressor of the C class floral homeotic gene AGAMOUS during the early stages of floral meristem development. Is part of the A class cadastral complex that define the boundaries between the A and C class homeotic genes expression and function. Interacts together with APETALA2 and LEUNIG to repress AGAMOUS expression. In association with LUG, regulates petal shape through AGAMOUS-independent mechanisms. Controls cell division during petal development and enable the proper patterning of petal blade vasculature. Required for the proper elaboration of petal polarity along the adaxial/abaxial axis. May act through direct or indirect regulation of PHABULOSA and YAB1 and thus regulate cellular proliferation within the developing petal blade. In association with AINTEGUMENTA (ANT), coordinates patterning cues and cellular proliferation along the three positional axes of the developing gynoecium. Required for the development of the medial ridge and subsequent ovule initiation..
• Protein Sequence: MVPSEPPNPVGGGENVPPSILGGQGGAPLPSQPAFPSLVSPRTQFGNNMSMSMLGNAPNISSLLNNQSFVNGIPGSMISMDTSGAESDPMSNVGFSGLSSFNASSMVSPRSSGQVQGQQFSNVSANQLLAEQQRNKKMETQSFQHGQQQSMQQQFSTVRGGGLAGVGPVKMEPGQVSNDQQHGQVQQQQQKMLRNLGSVKLEPQQIQAMRNLAQVKMEPQHSEQSLFLQQQQRQQQQQQQQQFLQMPGQSPQAQMNIFQQQRLMQLQQQQLLKSMPQQRPQLPQQFQQQNLPLRPPLKPVYEPGMGAQRLTQYMYRQQHRPEDNNIEFWRKFVAEYFAPNAKKRWCVSMYGSGRQTTGVFPQDVWHCEICNRKPGRGFEATAEVLPRLFKIKYESGTLEELLYVDMPRESQNSSGQIVLEYAKATQESVFEHLRVVRDGQLRIVFSPDLKIFSWEFCARRHEELIPRRLLIPQVSQLGSAAQKYQQAAQNATTDSALPELQNNCNMFVASARQLAKALEVPLVNDLGYTKRYVRCLQISEVVNSMKDLIDYSRETRTGPIESLAKFPRRTGPSSALPGPSPQQASDQLRQQQQQQQQQQQQQQQQQQQQQQQQTVSQNTNSDQSSRQVALMQGNPSNGVNYAFNAASASTSTSSIAGLIHQNSMKGRHQNAAYNPPNSPYGGNSVQMQSPSSSGTMVPSSSQQQHNLPTFQSPTSSSNNNNPSQNGIPSVNHMGSTNSPAMQQAGEVDGNESSSVQKILNEILMNNQAHNNSSGGSMVGHGSFGNDGKGQANVNSSGVLLMNGQVNNNNNTNIGGAGGFGGGIGQSMAANGINNINGNNSLMNGRVGMMVRDPNGQQDLGNQLLGAVNGFNNFDWNA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
108	Phosphorylation	FNASSMVSPRSSGQV CCCCCCCCCCCCCCC	13.12	29654922
171	Sulfoxidation	AGVGPVKMEPGQVSN CCCCCCCCCCCCCCC	8.38	23289948
198	Phosphorylation	KMLRNLGSVKLEPQQ HHHHHCCCCCCCHHH	21.17	30589143
200	Sumoylation	LRNLGSVKLEPQQIQ HHHCCCCCCCHHHHH	49.16	-
616	Phosphorylation	QQQQQTVSQNTNSDQ HHHHHHHHHHCCCCH	22.54	23328941

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SEUSS_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SEUSS_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SEUSS_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
LEUNG_ARATH	LUG	physical	15277686
AP1_ARATH	AP1	physical	16854969
SEP3_ARATH	SEP3	physical	16854969
AP3_ARATH	AP3	physical	16854969

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.