LEUNG_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: LEUNG_ARATH
• UniProt AC: Q9FUY2
• Protein Name: Transcriptional corepressor LEUNIG {ECO:0000303|PubMed:11058164}
• Gene Name: LUG {ECO:0000303|PubMed:11058164}
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 931
• Subcellular Localization: Nucleus .
• Protein Description: Transcription repressor subunit of the SEU-LUG transcriptional corepressor of the C class floral homeotic gene AGAMOUS during the early stages of floral meristem development. Is part of the A class cadastral complex that define the boundaries between the A and C class homeotic genes expression and function. Interacts together with APETALA2 and SEUSS to repress AGAMOUS expression. Also plays a role in ovule and pollen development. [PubMed: 11782418]
• Protein Sequence: MSQTNWEADKMLDVYIHDYLVKRDLKATAQAFQAEGKVSSDPVAIDAPGGFLFEWWSVFWDIFIARTNEKHSEVAASYIETQMIKAREQQLQQSQHPQVSQQQQQQQQQQIQMQQLLLQRAQQQQQQQQQQHHHHQQQQQQQQQQQQQQQQQQQQHQNQPPSQQQQQQSTPQHQQQPTPQQQPQRRDGSHLANGSANGLVGNNSEPVMRQNPGSGSSLASKAYEERVKMPTQRESLDEAAMKRFGDNVGQLLDPSHASILKSAAASGQPAGQVLHSTSGGMSPQVQTRNQQLPGSAVDIKSEINPVLTPRTAVPEGSLIGIPGSNQGSNNLTLKGWPLTGFDQLRSGLLQQQKPFMQSQSFHQLNMLTPQHQQQLMLAQQNLNSQSVSEENRRLKMLLNNRSMTLGKDGLGSSVGDVLPNVGSSLQPGGSLLPRGDTDMLLKLKMALLQQQQQNQQQGGGNPPQPQPQPQPLNQLALTNPQPQSSNHSIHQQEKLGGGGSITMDGSISNSFRGNEQVLKNQSGRKRKQPVSSSGPANSSGTANTAGPSPSSAPSTPSTHTPGDVISMPNLPHSGGSSKSMMMFGTEGTGTLTSPSNQLADMDRFVEDGSLDDNVESFLSQEDGDQRDAVTRCMDVSKGFTFTEVNSVRASTTKVTCCHFSSDGKMLASAGHDKKAVLWYTDTMKPKTTLEEHTAMITDIRFSPSQLRLATSSFDKTVRVWDADNKGYSLRTFMGHSSMVTSLDFHPIKDDLICSCDNDNEIRYWSINNGSCTRVYKGGSTQIRFQPRVGKYLAASSANLVNVLDVETQAIRHSLQGHANPINSVCWDPSGDFLASVSEDMVKVWTLGTGSEGECVHELSCNGNKFQSCVFHPAYPSLLVIGCYQSLELWNMSENKTMTLPAHEGLITSLAVSTATGLVASASHDKLVKLWK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
113	Sulfoxidation	QQQQQIQMQQLLLQR HHHHHHHHHHHHHHH	2.68	23289948
214	Phosphorylation	VMRQNPGSGSSLASK CCCCCCCCCCHHHHH	36.44	25561503
216	Phosphorylation	RQNPGSGSSLASKAY CCCCCCCCHHHHHHH	24.71	25561503
217	Phosphorylation	QNPGSGSSLASKAYE CCCCCCCHHHHHHHH	31.32	25561503
276	Phosphorylation	PAGQVLHSTSGGMSP CCCCEECCCCCCCCC	21.80	25561503
282	Phosphorylation	HSTSGGMSPQVQTRN CCCCCCCCCCCCCCC	18.56	29654922
308	Phosphorylation	SEINPVLTPRTAVPE HHCCCCCCCCCCCCC	15.80	23776212
593	Phosphorylation	EGTGTLTSPSNQLAD CCCCCCCCCHHHCCC	29.46	27531888
609	Phosphorylation	DRFVEDGSLDDNVES HHHCCCCCCCHHHHH	40.73	23776212
616	Phosphorylation	SLDDNVESFLSQEDG CCCHHHHHHHHCCCC	27.49	23776212
619	Phosphorylation	DNVESFLSQEDGDQR HHHHHHHHCCCCCHH	29.52	30291188

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of LEUNG_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of LEUNG_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of LEUNG_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
HDA19_ARATH	HD1	physical	17526732
SEUSS_ARATH	SEU	physical	15277686
SEUSS_ARATH	SEU	physical	16679456

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.