SERB_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SERB_HUMAN
• UniProt AC: P78330
• Protein Name: Phosphoserine phosphatase
• Gene Name: PSPH
• Organism: Homo sapiens (Human).
• Sequence Length: 225
• Protein Description: Catalyzes the last step in the biosynthesis of serine from carbohydrates. The reaction mechanism proceeds via the formation of a phosphoryl-enzyme intermediates..
• Protein Sequence: MVSHSELRKLFYSADAVCFDVDSTVIREEGIDELAKICGVEDAVSEMTRRAMGGAVPFKAALTERLALIQPSREQVQRLIAEQPPHLTPGIRELVSRLQERNVQVFLISGGFRSIVEHVASKLNIPATNVFANRLKFYFNGEYAGFDETQPTAESGGKGKVIKLLKEKFHFKKIIMIGDGATDMEACPPADAFIGFGGNVIRQQVKDNAKWYITDFVELLGELEE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MVSHSELR -------CCCHHHHH	6.69	19413330
3	Phosphorylation	-----MVSHSELRKL -----CCCHHHHHHH	21.72	22210691
47	Sulfoxidation	VEDAVSEMTRRAMGG CHHHHHHHHHHHHCC	2.48	30846556
52	Sulfoxidation	SEMTRRAMGGAVPFK HHHHHHHHCCCCCHH	4.89	21406390
59	Methylation	MGGAVPFKAALTERL HCCCCCHHHHHHHHH	27.04	115975903
88	Phosphorylation	AEQPPHLTPGIRELV HHCCCCCCHHHHHHH	19.21	-
122	Acetylation	IVEHVASKLNIPATN HHHHHHHHCCCCHHH	35.50	25953088
138	Phosphorylation	FANRLKFYFNGEYAG HHHCEEEEECCCCCC	8.44	22817900
143	Phosphorylation	KFYFNGEYAGFDETQ EEEECCCCCCCCCCC	17.27	22817900
158	Ubiquitination	PTAESGGKGKVIKLL CCCHHCCCCHHHHHH	60.11	21906983

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SERB_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SERB_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SERB_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
KPRA_HUMAN	PRPSAP1	physical	17353931
SERB_HUMAN	PSPH	physical	12213811
SERB_HUMAN	PSPH	physical	25416956
FAD1_HUMAN	FLAD1	physical	26344197
OGT1_HUMAN	OGT	physical	26344197
SERA_HUMAN	PHGDH	physical	26344197
TIM8B_HUMAN	TIMM8B	physical	26344197

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 614023: Phosphoserine phosphatase deficiency (PSPHD)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Acetylation

"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach.";
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.;
Anal. Chem. 81:4493-4501(2009).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, AND MASS SPECTROMETRY.
PubMed: 19413330