SCOT2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SCOT2_HUMAN
• UniProt AC: Q9BYC2
• Protein Name: Succinyl-CoA:3-ketoacid coenzyme A transferase 2, mitochondrial
• Gene Name: OXCT2
• Organism: Homo sapiens (Human).
• Sequence Length: 517
• Subcellular Localization: Mitochondrion .
• Protein Description: Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate (By similarity)..
• Protein Sequence: MAALRLLASVLGRGVPAGGSGLALSQGCARCFATSPRLRAKFYADPVEMVKDISDGATVMIGGFGLCGIPENLIAALLRTRVKDLQVVSSNVGVEDFGLGLLLAARQVRRIVCSYVGENTLCESQYLAGELELELTPQGTLAERIRAGGAGVPAFYTPTGYGTLVQEGGAPIRYTPDGHLALMSQPREVREFNGDHFLLERAIRADFALVKGWKADRAGNVVFRRSARNFNVPMCKAADVTAVEVEEIVEVGAFPPEDIHVPNIYVDRVIKGQKYEKRIERLTILKEEDGDAGKEEDARTRIIRRAALEFEDGMYANLGIGIPLLASNFISPSMTVHLHSENGILGLGPFPTEDEVDADLINAGKQTVTVLPGGCFFASDDSFAMIRGGHIQLTMLGAMQVSKYGDLANWMIPGKKVKGMGGAMDLVSSQKTRVVVTMQHCTKDNTPKIMEKCTMPLTGKRCVDRIITEKAVFDVHRKKELTLRELWEGLTVDDIKKSTGCAFAVSPNLRPMQQVAP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
89	Phosphorylation	VKDLQVVSSNVGVED HCCCEEEECCCCCCH	19.82	-
90	Phosphorylation	KDLQVVSSNVGVEDF CCCEEEECCCCCCHH	24.75	-
157	Phosphorylation	AGVPAFYTPTGYGTL CCCCEEECCCCCCCE	14.12	-
226	Phosphorylation	GNVVFRRSARNFNVP CCEEEEECCCCCCCC	27.59	27282143
286	Acetylation	IERLTILKEEDGDAG HHHEEEEECCCCCCC	56.03	25038526
294	Acetylation	EEDGDAGKEEDARTR CCCCCCCCHHHHHHH	60.70	25038526
394	Phosphorylation	RGGHIQLTMLGAMQV ECCEEEEEEECCEEE	8.25	21406692
402	Phosphorylation	MLGAMQVSKYGDLAN EECCEEEHHHCCHHC	11.85	21406692
404	Phosphorylation	GAMQVSKYGDLANWM CCEEEHHHCCHHCCC	14.36	-
428	Phosphorylation	GGAMDLVSSQKTRVV CCCHHHHHCCCCEEE	34.06	29038488
429	Phosphorylation	GAMDLVSSQKTRVVV CCHHHHHCCCCEEEE	28.37	29038488
432	Phosphorylation	DLVSSQKTRVVVTMQ HHHHCCCCEEEEEEE	22.51	29038488
458	O-linked_Glycosylation	EKCTMPLTGKRCVDR HHCCCCCCCCCHHHH	34.48	30379171

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SCOT2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SCOT2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SCOT2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SCOT2_HUMAN	OXCT2	physical	11327867
MCCA_HUMAN	MCCC1	physical	26186194
SCOT2_HUMAN	OXCT2	physical	27499296
NDKM_HUMAN	NME4	physical	27499296
ECHD1_HUMAN	ECHDC1	physical	27499296
ODBA_HUMAN	BCKDHA	physical	27499296
MPPB_HUMAN	PMPCB	physical	27499296
ECH1_HUMAN	ECH1	physical	27499296
NFS1_HUMAN	NFS1	physical	27499296
ATP5E_HUMAN	ATP5E	physical	27499296
SCOT1_HUMAN	OXCT1	physical	27499296
C1QBP_HUMAN	C1QBP	physical	27499296
NDUF7_HUMAN	NDUFAF7	physical	28514442
MCCA_HUMAN	MCCC1	physical	28514442
CH60_HUMAN	HSPD1	physical	28514442
ATPF1_HUMAN	ATPAF1	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.