SACA3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SACA3_HUMAN
• UniProt AC: Q8IXA5
• Protein Name: Sperm acrosome membrane-associated protein 3
• Gene Name: SPACA3
• Organism: Homo sapiens (Human).
• Sequence Length: 215
• Subcellular Localization: Isoform 1: Cytoplasmic vesicle, secretory vesicle, acrosome membrane ; Single-pass type II membrane protein . Anterior acrosome in non-capacitated spermatozoa and retained in the equatorial segment and in the luminal face of both the inner and outer
• Protein Description: Sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during fertilization. It could be a potential receptor for the egg oligosaccharide residue N-acetylglucosamine, which is present in the extracellular matrix over the egg plasma membrane. The processed form has no detectable bacteriolytic activity in vitro..
• Protein Sequence: MVSALRGAPLIRVHSSPVSSPSVSGPRRLVSCLSSQSSALSQSGGGSTSAAGIEARSRALRRRWCPAGIMLLALVCLLSCLLPSSEAKLYGRCELARVLHDFGLDGYRGYSLADWVCLAYFTSGFNAAALDYEADGSTNNGIFQINSRRWCSNLTPNVPNVCRMYCSDLLNPNLKDTVICAMKITQEPQGLGYWEAWRHHCQGKDLTEWVDGCDF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
22	Phosphorylation	SSPVSSPSVSGPRRL CCCCCCCCCCCCHHH	30.75	30576142
24	Phosphorylation	PVSSPSVSGPRRLVS CCCCCCCCCCHHHHH	47.63	30576142
35	Phosphorylation	RLVSCLSSQSSALSQ HHHHHHHHCCCHHHH	22.57	22817900
37	Phosphorylation	VSCLSSQSSALSQSG HHHHHHCCCHHHHCC	21.37	22817900
43	Phosphorylation	QSSALSQSGGGSTSA CCCHHHHCCCCCHHH	35.71	19690332
152	Phosphorylation	INSRRWCSNLTPNVP ECCCEEHHCCCCCCC	28.10	25693802
155	Phosphorylation	RRWCSNLTPNVPNVC CEEHHCCCCCCCCHH	19.64	25693802
204	Acetylation	WRHHCQGKDLTEWVD HHHHHCCCCHHHHCC	24.56	25038526

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SACA3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SACA3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SACA3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
FKB14_HUMAN	FKBP14	physical	28514442
AADAT_HUMAN	AADAT	physical	28514442
FKBP7_HUMAN	FKBP7	physical	28514442
GRP78_HUMAN	HSPA5	physical	28514442
ANR46_HUMAN	ANKRD46	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.