AADAT_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: AADAT_HUMAN
• UniProt AC: Q8N5Z0
• Protein Name: Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial
• Gene Name: AADAT
• Organism: Homo sapiens (Human).
• Sequence Length: 425
• Subcellular Localization: Mitochondrion .
• Protein Description: Transaminase with broad substrate specificity. Has transaminase activity towards aminoadipate, kynurenine, methionine and glutamate. Shows activity also towards tryptophan, aspartate and hydroxykynurenine. Accepts a variety of oxo-acids as amino-group acceptors, with a preference for 2-oxoglutarate, 2-oxocaproic acid, phenylpyruvate and alpha-oxo-gamma-methiol butyric acid. Can also use glyoxylate as amino-group acceptor (in vitro)..
• Protein Sequence: MNYARFITAASAARNPSPIRTMTDILSRGPKSMISLAGGLPNPNMFPFKTAVITVENGKTIQFGEEMMKRALQYSPSAGIPELLSWLKQLQIKLHNPPTIHYPPSQGQMDLCVTSGSQQGLCKVFEMIINPGDNVLLDEPAYSGTLQSLHPLGCNIINVASDESGIVPDSLRDILSRWKPEDAKNPQKNTPKFLYTVPNGNNPTGNSLTSERKKEIYELARKYDFLIIEDDPYYFLQFNKFRVPTFLSMDVDGRVIRADSFSKIISSGLRIGFLTGPKPLIERVILHIQVSTLHPSTFNQLMISQLLHEWGEEGFMAHVDRVIDFYSNQKDAILAAADKWLTGLAEWHVPAAGMFLWIKVKGINDVKELIEEKAVKMGVLMLPGNAFYVDSSAPSPYLRASFSSASPEQMDVAFQVLAQLIKESL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
31	Acetylation	DILSRGPKSMISLAG HHHHHCCHHHHHHCC	56.32	20167786
32	Phosphorylation	ILSRGPKSMISLAGG HHHHCCHHHHHHCCC	25.20	29759185
35	Phosphorylation	RGPKSMISLAGGLPN HCCHHHHHHCCCCCC	11.97	29759185
39 (in isoform 2)	Phosphorylation	-	32.14	22210691
49	Acetylation	NPNMFPFKTAVITVE CCCCCCCCEEEEEEE	35.49	20167786
69	Acetylation	QFGEEMMKRALQYSP ECCHHHHHHHHHHCC	32.96	2380865
176	Phosphorylation	DSLRDILSRWKPEDA HHHHHHHHHCCHHHC	36.11	46156151
179	Acetylation	RDILSRWKPEDAKNP HHHHHHCCHHHCCCC	37.10	-
260	Phosphorylation	GRVIRADSFSKIISS CCEEEHHHHHHHHHC	30.36	24719451
263	Other	IRADSFSKIISSGLR EEHHHHHHHHHCCCE	41.89	-
263	Succinylation	IRADSFSKIISSGLR EEHHHHHHHHHCCCE	41.89	-
263	Acetylation	IRADSFSKIISSGLR EEHHHHHHHHHCCCE	41.89	-
263	N6-(pyridoxal phosphate)lysine	IRADSFSKIISSGLR EEHHHHHHHHHCCCE	41.89	-
339	Succinylation	AILAAADKWLTGLAE HHHHHHHHHHHHHHH	39.10	-
339	Acetylation	AILAAADKWLTGLAE HHHHHHHHHHHHHHH	39.10	-
339	Succinylation	AILAAADKWLTGLAE HHHHHHHHHHHHHHH	39.10	-
367	Acetylation	VKGINDVKELIEEKA EECCCCHHHHHHHHH	50.06	-
367	Succinylation	VKGINDVKELIEEKA EECCCCHHHHHHHHH	50.06	-
367	Ubiquitination	VKGINDVKELIEEKA EECCCCHHHHHHHHH	50.06	-
367	Succinylation	VKGINDVKELIEEKA EECCCCHHHHHHHHH	50.06	-
422	Acetylation	QVLAQLIKESL---- HHHHHHHHHHC----	50.25	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of AADAT_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of AADAT_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of AADAT_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of AADAT_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.