S38A6_HUMAN - dbPTM
S38A6_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID S38A6_HUMAN
UniProt AC Q8IZM9
Protein Name Probable sodium-coupled neutral amino acid transporter 6
Gene Name SLC38A6
Organism Homo sapiens (Human).
Sequence Length 456
Subcellular Localization Cell membrane
Multi-pass membrane protein . Colocalizes with synaptotagmins and SNAP25.
Protein Description Probable sodium-dependent amino acid/proton antiporter, could be a neuronal transporter for glutamate..
Protein Sequence MEASWGSFNAERGWYVSVQQPEEAEAEELSPLLSNELHRQRSPGVSFGLSVFNLMNAIMGSGILGLAYVLANTGVFGFSFLLLTVALLASYSVHLLLSMCIQTAVTSYEDLGLFAFGLPGKLVVAGTIIIQNIGAMSSYLLIIKTELPAAIAEFLTGDYSRYWYLDGQTLLIIICVGIVFPLALLPKIGFLGYTSSLSFFFMMFFALVVIIKKWSIPCPLTLNYVEKGFQISNVTDDCKPKLFHFSKESAYALPTMAFSFLCHTSILPIYCELQSPSKKRMQNVTNTAIALSFLIYFISALFGYLTFYDKVESELLKGYSKYLSHDVVVMTVKLCILFAVLLTVPLIHFPARKAVTMMFFSNFPFSWIRHFLITLALNIIIVLLAIYVPDIRNVFGVVGASTSTCLIFIFPGLFYLKLSREDFLSWKKLGAFVLLIFGILVGNFSLALIIFDWINK
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure
ASA (%) Reference Orthologous
Protein Cluster
1Acetylation-------MEASWGSF
-------CCCCCCCC
9.7820068231
4Phosphorylation----MEASWGSFNAE
----CCCCCCCCCCC
20.7520068231
7Phosphorylation-MEASWGSFNAERGW
-CCCCCCCCCCCCCE
14.7420068231
233N-linked_GlycosylationEKGFQISNVTDDCKP
HCCEEEECCCCCCCC
42.19UniProtKB CARBOHYD
283N-linked_GlycosylationPSKKRMQNVTNTAIA
CCHHHHCHHHHHHHH
32.98UniProtKB CARBOHYD
299PhosphorylationSFLIYFISALFGYLT
HHHHHHHHHHHHHHH
14.7122210691
304PhosphorylationFISALFGYLTFYDKV
HHHHHHHHHHHHHHH
8.6722210691
306PhosphorylationSALFGYLTFYDKVES
HHHHHHHHHHHHHHH
16.2122210691
322PhosphorylationLLKGYSKYLSHDVVV
HHHHHHHHCCCCHHH
13.9029759185
435 (in isoform 2)Phosphorylation-2.28-
473 (in isoform 2)Phosphorylation--
478 (in isoform 2)Phosphorylation--

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of S38A6_HUMAN !!

Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of S38A6_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10)
Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of S38A6_HUMAN !!

Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
TRFE_HUMANTFphysical
26186194
NPL4_HUMANNPLOC4physical
26186194
MUCL1_HUMANMUCL1physical
26186194
APOB_HUMANAPOBphysical
26186194
MTCH2_HUMANMTCH2physical
26186194
ZG16B_HUMANZG16Bphysical
26186194
CYB5_HUMANCYB5Aphysical
26186194
RFOX3_HUMANRBFOX3physical
26186194
TRFE_HUMANTFphysical
28514442

Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of S38A6_HUMAN

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Related Literatures of Post-Translational Modification

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