| UniProt ID | S38A6_HUMAN | |
|---|---|---|
| UniProt AC | Q8IZM9 | |
| Protein Name | Probable sodium-coupled neutral amino acid transporter 6 | |
| Gene Name | SLC38A6 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 456 | |
| Subcellular Localization |
Cell membrane Multi-pass membrane protein . Colocalizes with synaptotagmins and SNAP25. |
|
| Protein Description | Probable sodium-dependent amino acid/proton antiporter, could be a neuronal transporter for glutamate.. | |
| Protein Sequence | MEASWGSFNAERGWYVSVQQPEEAEAEELSPLLSNELHRQRSPGVSFGLSVFNLMNAIMGSGILGLAYVLANTGVFGFSFLLLTVALLASYSVHLLLSMCIQTAVTSYEDLGLFAFGLPGKLVVAGTIIIQNIGAMSSYLLIIKTELPAAIAEFLTGDYSRYWYLDGQTLLIIICVGIVFPLALLPKIGFLGYTSSLSFFFMMFFALVVIIKKWSIPCPLTLNYVEKGFQISNVTDDCKPKLFHFSKESAYALPTMAFSFLCHTSILPIYCELQSPSKKRMQNVTNTAIALSFLIYFISALFGYLTFYDKVESELLKGYSKYLSHDVVVMTVKLCILFAVLLTVPLIHFPARKAVTMMFFSNFPFSWIRHFLITLALNIIIVLLAIYVPDIRNVFGVVGASTSTCLIFIFPGLFYLKLSREDFLSWKKLGAFVLLIFGILVGNFSLALIIFDWINK | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
|
|
||
* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 1 | Acetylation | -------MEASWGSF -------CCCCCCCC | 9.78 | 20068231 | |
| 4 | Phosphorylation | ----MEASWGSFNAE ----CCCCCCCCCCC | 20.75 | 20068231 | |
| 7 | Phosphorylation | -MEASWGSFNAERGW -CCCCCCCCCCCCCE | 14.74 | 20068231 | |
| 233 | N-linked_Glycosylation | EKGFQISNVTDDCKP HCCEEEECCCCCCCC | 42.19 | UniProtKB CARBOHYD | |
| 283 | N-linked_Glycosylation | PSKKRMQNVTNTAIA CCHHHHCHHHHHHHH | 32.98 | UniProtKB CARBOHYD | |
| 299 | Phosphorylation | SFLIYFISALFGYLT HHHHHHHHHHHHHHH | 14.71 | 22210691 | |
| 304 | Phosphorylation | FISALFGYLTFYDKV HHHHHHHHHHHHHHH | 8.67 | 22210691 | |
| 306 | Phosphorylation | SALFGYLTFYDKVES HHHHHHHHHHHHHHH | 16.21 | 22210691 | |
| 322 | Phosphorylation | LLKGYSKYLSHDVVV HHHHHHHHCCCCHHH | 13.90 | 29759185 | |
| 435 (in isoform 2) | Phosphorylation | - | 2.28 | - | |
| 473 (in isoform 2) | Phosphorylation | - | - | ||
| 478 (in isoform 2) | Phosphorylation | - | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of S38A6_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of S38A6_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of S38A6_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| TRFE_HUMAN | TF | physical | 26186194 | |
| NPL4_HUMAN | NPLOC4 | physical | 26186194 | |
| MUCL1_HUMAN | MUCL1 | physical | 26186194 | |
| APOB_HUMAN | APOB | physical | 26186194 | |
| MTCH2_HUMAN | MTCH2 | physical | 26186194 | |
| ZG16B_HUMAN | ZG16B | physical | 26186194 | |
| CYB5_HUMAN | CYB5A | physical | 26186194 | |
| RFOX3_HUMAN | RBFOX3 | physical | 26186194 | |
| TRFE_HUMAN | TF | physical | 28514442 |
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
loading...
