S35A5_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: S35A5_HUMAN
• UniProt AC: Q9BS91
• Protein Name: Probable UDP-sugar transporter protein SLC35A5
• Gene Name: SLC35A5
• Organism: Homo sapiens (Human).
• Sequence Length: 424
• Subcellular Localization: Membrane ; Multi-pass membrane protein .
• Protein Sequence: MEKQCCSHPVICSLSTMYTFLLGAIFIALSSSRILLVKYSANEENKYDYLPTTVNVCSELVKLVFCVLVSFCVIKKDHQSRNLKYASWKEFSDFMKWSIPAFLYFLDNLIVFYVLSYLQPAMAVIFSNFSIITTALLFRIVLKRRLNWIQWASLLTLFLSIVALTAGTKTLQHNLAGRGFHHDAFFSPSNSCLLFRSECPRKDNCTAKEWTFPEAKWNTTARVFSHIRLGMGHVLIIVQCFISSMANIYNEKILKEGNQLTESIFIQNSKLYFFGILFNGLTLGLQRSNRDQIKNCGFFYGHSAFSVALIFVTAFQGLSVAFILKFLDNMFHVLMAQVTTVIITTVSVLVFDFRPSLEFFLEAPSVLLSIFIYNASKPQVPEYAPRQERIRDLSGNLWERSSGDGEELERLTKPKSDESDEDTF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
18	Phosphorylation	ICSLSTMYTFLLGAI HHHHHHHHHHHHHHH	8.40	-
19	Phosphorylation	CSLSTMYTFLLGAIF HHHHHHHHHHHHHHH	9.29	-
87	Phosphorylation	SRNLKYASWKEFSDF CCCCCCCCHHHHHHH	35.27	24719451
170	Phosphorylation	ALTAGTKTLQHNLAG HHHCCCCHHHHHCCC	31.33	24114839
204	N-linked_Glycosylation	SECPRKDNCTAKEWT CCCCCCCCCCCCCCC	28.24	UniProtKB CARBOHYD
225	Phosphorylation	NTTARVFSHIRLGMG CCHHHHHHHHHCCCC	18.36	-
243	Phosphorylation	IIVQCFISSMANIYN HHHHHHHHHHHHHHC	8.20	-
288	Phosphorylation	LTLGLQRSNRDQIKN HHHCCCCCCHHHHHH	24.21	-
394	Phosphorylation	QERIRDLSGNLWERS HHHHHHHCCCCCCCC	29.89	19664994
401	Phosphorylation	SGNLWERSSGDGEEL CCCCCCCCCCCHHHH	27.45	29255136
402	Phosphorylation	GNLWERSSGDGEELE CCCCCCCCCCHHHHH	47.31	23401153
412	Phosphorylation	GEELERLTKPKSDES HHHHHHHCCCCCCCC	52.07	23403867
416	Phosphorylation	ERLTKPKSDESDEDT HHHCCCCCCCCCCCC	55.95	28355574
419	Phosphorylation	TKPKSDESDEDTF-- CCCCCCCCCCCCC--	51.82	28355574
423	Phosphorylation	SDESDEDTF------ CCCCCCCCC------	29.24	21955146

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of S35A5_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of S35A5_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of S35A5_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MBOA7_HUMAN	MBOAT7	physical	26186194
TNKS2_HUMAN	TNKS2	physical	26186194
TNKS1_HUMAN	TNKS	physical	26186194
CGAT2_HUMAN	CSGALNACT2	physical	26186194
S41A1_HUMAN	SLC41A1	physical	26186194
RHOB_HUMAN	RHOB	physical	26186194
TNKS2_HUMAN	TNKS2	physical	28514442
TNKS1_HUMAN	TNKS	physical	28514442
CGAT2_HUMAN	CSGALNACT2	physical	28514442
MBOA7_HUMAN	MBOAT7	physical	28514442
ACL6B_HUMAN	ACTL6B	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-416 AND SER-419, ANDMASS SPECTROMETRY.
PubMed: 18669648