ROP1L_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ROP1L_HUMAN
• UniProt AC: Q96C74
• Protein Name: Ropporin-1-like protein
• Gene Name: ROPN1L
• Organism: Homo sapiens (Human).
• Sequence Length: 230
• Subcellular Localization: Cell projection, cilium, flagellum . Cell projection, cilium .
• Protein Description: Important for male fertility. With ROPN1, involved in fibrous sheath integrity and sperm motility, plays a role in PKA-dependent signaling processes required for spermatozoa capacitation..
• Protein Sequence: MPLPDTMFCAQQIHIPPELPDILKQFTKAAIRTQPADVLRWSAGYFSALSRGDPLPVKDRMEMPTATQKTDTGLTQGLLKVLHKQCHHKRYVELTDLEQKWKNLCLPKEKFKALLQLDPCENKIKWINFLALGCSMLGGSLNTALKHLCEILTDDPEGGPARIPFKTFSYVYRYLARLDSDVSPLETESYLASLKENIDARKNGMIGLSDFFFPKRKLLESIENSEDVGH

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
28	Ubiquitination	DILKQFTKAAIRTQP HHHHHHHHHHHHHCC	36.79	29967540
33	O-linked_Glycosylation	FTKAAIRTQPADVLR HHHHHHHHCCHHHHH	32.56	30379171
65	Phosphorylation	KDRMEMPTATQKTDT CCCCCCCCCCCCCCC	40.81	29396449
67	Phosphorylation	RMEMPTATQKTDTGL CCCCCCCCCCCCCCH	32.83	29396449
70	Phosphorylation	MPTATQKTDTGLTQG CCCCCCCCCCCHHHH	29.04	29396449
72	Phosphorylation	TATQKTDTGLTQGLL CCCCCCCCCHHHHHH	39.04	29396449
75	Phosphorylation	QKTDTGLTQGLLKVL CCCCCCHHHHHHHHH	23.18	23532336
180	Phosphorylation	RYLARLDSDVSPLET HHHHHCCCCCCCCCC	44.49	25693802
195	Acetylation	ESYLASLKENIDARK HHHHHHHHHHHHHHH	46.34	25038526
221	Phosphorylation	PKRKLLESIENSEDV CHHHHHHHHHCCCCC	34.86	29666759
225	Phosphorylation	LLESIENSEDVGH-- HHHHHHCCCCCCC--	23.53	29666759

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ROP1L_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ROP1L_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ROP1L_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049
RSPH3_HUMAN	RSPH3	physical	25416956
AKAP9_HUMAN	AKAP9	physical	26186194
SP17_HUMAN	SPA17	physical	26186194
SP17_HUMAN	SPA17	physical	28514442
AKAP9_HUMAN	AKAP9	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.