RILP_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RILP_HUMAN
• UniProt AC: Q96NA2
• Protein Name: Rab-interacting lysosomal protein
• Gene Name: RILP
• Organism: Homo sapiens (Human).
• Sequence Length: 401
• Subcellular Localization: Late endosome membrane . Lysosome membrane . Cytoplasmic vesicle, phagosome membrane . Associated with late endosomal, lysosomal and phagosomal membranes. The interaction with RAB7A is necessary for its recruitment to phagosomes.
• Protein Description: Rab effector playing a role in late endocytic transport to degradative compartments. Involved in the regulation of lysosomal morphology and distribution. Induces recruitment of dynein-dynactin motor complexes to Rab7A-containing late endosome and lysosome compartments. Promotes centripetal migration of phagosomes and the fusion of phagosomes with the late endosomes and lysosomes..
• Protein Sequence: MEPRRAAPGVPGWGSREAAGSASAAELVYHLAGALGTELQDLARRFGPEAAAGLVPLVVRALELLEQAAVGPAPDSLQVSAQPAEQELRRLREENERLRRELRAGPQEERALLRQLKEVTDRQRDELRAHNRDLRQRGQETEALQEQLQRLLLVNAELRHKLAAMQTQLRAAQDRERERQQPGEAATPQAKERARGQAGRPGHQHGQEPEWATAGAGAPGNPEDPAEAAQQLGRPSEAGQCRFSREEFEQILQERNELKAKVFLLKEELAYFQRELLTDHRVPGLLLEAMKVAVRKQRKKIKAKMLGTPEEAESSEDEAGPWILLSDDKGDHPPPPESKIQSFFGLWYRGKAESSEDETSSPAPSKLGGEEEAQPQSPAPDPPCSALHEHLCLGASAAPEA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
187	Phosphorylation	QQPGEAATPQAKERA CCCCCCCCHHHHHHH	24.00	25262027
308	Phosphorylation	IKAKMLGTPEEAESS HHHHHCCCHHHHHCC	24.46	20068231
314	Phosphorylation	GTPEEAESSEDEAGP CCHHHHHCCCCCCCC	46.18	25159151
315	Phosphorylation	TPEEAESSEDEAGPW CHHHHHCCCCCCCCE	40.34	15933719
326	Phosphorylation	AGPWILLSDDKGDHP CCCEEEEECCCCCCC	40.08	20068231
338	Phosphorylation	DHPPPPESKIQSFFG CCCCCCHHHHHHHHH	40.61	20068231
354	Phosphorylation	WYRGKAESSEDETSS HHCCCCCCCCCCCCC	43.84	25159151
355	Phosphorylation	YRGKAESSEDETSSP HCCCCCCCCCCCCCC	40.34	25159151
359	Phosphorylation	AESSEDETSSPAPSK CCCCCCCCCCCCCHH	46.99	29396449
360	Phosphorylation	ESSEDETSSPAPSKL CCCCCCCCCCCCHHC	32.07	29396449
361	Phosphorylation	SSEDETSSPAPSKLG CCCCCCCCCCCHHCC	32.28	25627689
365	Phosphorylation	ETSSPAPSKLGGEEE CCCCCCCHHCCCCCC	42.49	-
377	Phosphorylation	EEEAQPQSPAPDPPC CCCCCCCCCCCCCCC	29.70	30576142

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RILP_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RILP_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RILP_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RAB7A_HUMAN	RAB7A	physical	11448994
VPS36_HUMAN	VPS36	physical	17010938
SNF8_HUMAN	SNF8	physical	17010938
RAB7A_HUMAN	RAB7A	physical	18552835
RAB7B_HUMAN	RAB7B	physical	18552835
VPS11_HUMAN	VPS11	physical	25445562
VPS16_HUMAN	VPS16	physical	25445562
VPS18_HUMAN	VPS18	physical	25445562
VPS39_HUMAN	VPS39	physical	25445562
VPS41_HUMAN	VPS41	physical	25445562
RAB7A_HUMAN	RAB7A	physical	25445562
RAB7A_HUMAN	RAB7A	physical	26911690
RAB7A_HUMAN	RAB7A	physical	25080504

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-314 AND SER-315, ANDMASS SPECTROMETRY.
PubMed: 18669648