RHNO1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RHNO1_HUMAN
• UniProt AC: Q9BSD3
• Protein Name: RAD9, HUS1, RAD1-interacting nuclear orphan protein 1
• Gene Name: RHNO1
• Organism: Homo sapiens (Human).
• Sequence Length: 238
• Subcellular Localization: Nucleus . Chromosome . Localizes to sites of DNA damage in a H2AX-independent manner.
• Protein Description: Plays a role in DNA damage response (DDR) signaling upon genotoxic stresses such as ionizing radiation (IR) during the S phase. Recruited to sites of DNA damage through interaction with the 9-1-1 cell-cycle checkpoint response complex and TOPBP1 in a ATR-dependent manner. Required for the progression of the G1 to S phase transition. Plays a role in the stimulation of CHEK1 phosphorylation..
• Protein Sequence: MPPRKKRRQPSQKAPLLFHQQPLEGPKHSCASTQLPITHTRQVPSKPIDHSTITSWVSPDFDTAAGSLFPAYQKHQNRARHSSRKPTTSKFPHLTFESPQSSSSETLGIPLIRECPSESEKDVSRRPLVPVLSPQSCGNMSVQALQSLPYVFIPPDIQTPESSSVKEELIPQDQKENSLLSCTLHTGTPNSPEPGPVLVKDTPEDKYGIKVTWRRRQHLLAYLRERGKLSRSQFLVKS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
33	Phosphorylation	PKHSCASTQLPITHT CCCCCCCCCCCEECC		17525332
87	Phosphorylation	RHSSRKPTTSKFPHL HHCCCCCCCCCCCCC		29083192
88	Phosphorylation	HSSRKPTTSKFPHLT HCCCCCCCCCCCCCE		29083192
89	Phosphorylation	SSRKPTTSKFPHLTF CCCCCCCCCCCCCEE		29083192
95	Phosphorylation	TSKFPHLTFESPQSS CCCCCCCEECCCCCC		29083192
98	Phosphorylation	FPHLTFESPQSSSSE CCCCEECCCCCCCCC		25159151
101	Phosphorylation	LTFESPQSSSSETLG CEECCCCCCCCCCCC		29083192
102	Phosphorylation	TFESPQSSSSETLGI EECCCCCCCCCCCCC		29083192
103	Phosphorylation	FESPQSSSSETLGIP ECCCCCCCCCCCCCC		29083192
104	Phosphorylation	ESPQSSSSETLGIPL CCCCCCCCCCCCCCE		29083192
222	Phosphorylation	RRQHLLAYLRERGKL HHHHHHHHHHHCCCC		28331001
232	Phosphorylation	ERGKLSRSQFLVKS- HCCCCCHHHHCCCC-		21712546
238	Phosphorylation	RSQFLVKS------- HHHHCCCC-------		21712546

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RHNO1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RHNO1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RHNO1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
LZTS2_HUMAN	LZTS2	physical	25416956
KR109_HUMAN	KRTAP10-9	physical	25416956
KR103_HUMAN	KRTAP10-3	physical	25416956
TOPB1_HUMAN	TOPBP1	physical	21659603
RAD9A_HUMAN	RAD9A	physical	21659603
RAD18_HUMAN	RAD18	physical	21659603
UBE2N_HUMAN	UBE2N	physical	21659603
HUS1_HUMAN	HUS1	physical	21659603
RAD1_HUMAN	RAD1	physical	21659603

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.