RGA1_SCHPO - dbPTM
RGA1_SCHPO - PTM Information in dbPTM
Basic Information of Protein
UniProt ID RGA1_SCHPO
UniProt AC O43052
Protein Name Rho-type GTPase-activating protein 1
Gene Name rga1
Organism Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
Sequence Length 1150
Subcellular Localization Cell septum . Cell poles and septum.
Protein Description GTPase-activating protein for Rho1. Involved in the F-actin patch localization, cell morphogenesis, regulation of septation, and cell wall synthesis..
Protein Sequence MSQRDAKKDGLLYTTNGVSPTPPKRIPVPSRQNKIEENSTTKNFPHSRHTSTVAGTEGGSSLSRRHTSAESRKALPNQQQLAQSGLLNKEEQQSLKRSDTSVFPKAVRKVSSSKICASCGQVISGQYVRALGNIYHLECFRCHDCNSLVASKFFPIDDPTLNKQVPLCETDYFRRLDLLCASCGMALRGYYITALNKKFHIEHFTCSLCYTVFGPNDSYYEYEGKVYCHYHYSTLFAARCCGCDGPILRQFVEVYRNGVSQNWHVPCHMIYKFWNVKLCQKTSIETSKKKDSELSQSQLRKREKHLEQKIFHIWHALSYFEEYTASCISDMLLLVSNGEFTKSVICAQKFIRYIEILFKGIDSLETILSSFHAKSMPYVREAKLLCKKLVSIFALLAKCHNSDIRDVAIVQDFLSLFTGLAHYLKLLIRISLTGGLRLEQDHACKHALPQFLQTVEEARFVDQEGYDSSSFDMPLNLANASSDLCYVCHSALEEDCVLLGEIRCHIGCLSCTKCKYNNRENYDWARWNNQTKQIECYLCYTESSNVSNDEPHPSFEYVSRLSQYIYLLRIALVRLYTILMENNDSSQRKPLSVDPKQENVSSTVETAKQAETTASSDSFRKYANTLNDLRHLKSSRNRKATSNETQSSSNSTETSKLSKNVSESGKDKSPHWHSHGGSITGKSIVEQASSPLERRMDAFDENRAFTLDDIPKVISEQRNREHRPNAFRHMPSYTDPSYRKNSGAIYDKNDGTQKGLTPKSEDAPIRYLSDLSNLELLFTKHVAVLILHPLVRDYYSLDELMEMSDLRKGGFWEKFGKAFKGKDAEKKNVKKKGTFGVPLEILVERNNAQSTVGTGVGVKHIPAFIGNTLAAMKRKDMSVVGVFRKNGNIRRLKELSDMLDVSPDSIDYEQETPIQLAALLKKFLRELPDPLLTFKLFGLFITSSKLESEEERMRVLHLTICLLPKGHRDTMEVIFGFLYWVASFSHIDDEVGSKMDIHNLATVITPNILYSKSNDPVDESFLAIEAVHLLIENFEKFCEVPREISLLLDDPTLFYNNAAWTSKELYKRCEEIISQMSLDERNTPKHTASTKRKRQPIRRVTTNLTSDVPSGSEVADTNSLSSTTKDEASPNSDAQPKPQVKPQHAVIRDS
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
19PhosphorylationLYTTNGVSPTPPKRI
EEECCCCCCCCCCCC		25.1829996109
21PhosphorylationTTNGVSPTPPKRIPV
ECCCCCCCCCCCCCC		44.7229996109
51PhosphorylationFPHSRHTSTVAGTEG
CCCCCCCCCCCCCCC		18.1129996109
60PhosphorylationVAGTEGGSSLSRRHT
CCCCCCCCCCHHHCC		38.6729996109
61PhosphorylationAGTEGGSSLSRRHTS
CCCCCCCCCHHHCCC		33.3729996109
63PhosphorylationTEGGSSLSRRHTSAE
CCCCCCCHHHCCCHH		29.2625720772
295PhosphorylationKKKDSELSQSQLRKR
CHHCCCCCHHHHHHH		24.5921712547
297PhosphorylationKDSELSQSQLRKREK
HCCCCCHHHHHHHHH		28.0128889911
651PhosphorylationETQSSSNSTETSKLS
CCCCCCCCHHHHHHC		29.5727738172
669PhosphorylationSESGKDKSPHWHSHG
HHHCCCCCCCCCCCC		31.9321712547
674PhosphorylationDKSPHWHSHGGSITG
CCCCCCCCCCCCCCC		20.7321712547
678PhosphorylationHWHSHGGSITGKSIV
CCCCCCCCCCCHHHH		22.9021712547
680PhosphorylationHSHGGSITGKSIVEQ
CCCCCCCCCHHHHHH		40.0121712547
683PhosphorylationGGSITGKSIVEQASS
CCCCCCHHHHHHCCC		32.9629996109
689PhosphorylationKSIVEQASSPLERRM
HHHHHHCCCHHHHCC		31.9829996109
690PhosphorylationSIVEQASSPLERRMD
HHHHHCCCHHHHCCH		36.2028889911
1117PhosphorylationSGSEVADTNSLSSTT
CCCCCCCCCCCCCCC		19.5724763107
1119PhosphorylationSEVADTNSLSSTTKD
CCCCCCCCCCCCCCC		31.5524763107
1121PhosphorylationVADTNSLSSTTKDEA
CCCCCCCCCCCCCCC		26.0121712547
1122PhosphorylationADTNSLSSTTKDEAS
CCCCCCCCCCCCCCC		45.4421712547
1123PhosphorylationDTNSLSSTTKDEASP
CCCCCCCCCCCCCCC		34.1929996109
1124PhosphorylationTNSLSSTTKDEASPN
CCCCCCCCCCCCCCC		38.1529996109
1150PhosphorylationQHAVIRDS-------
CCEECCCC-------		32.0724763107
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of RGA1_SCHPO !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of RGA1_SCHPO !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of RGA1_SCHPO !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
RGF1_SCHPOrgf1genetic
16324155
POM1_SCHPOpom1physical
18328707
RGF1_SCHPOrgf1genetic
16421249
PCK1_SCHPOpck1genetic
11737264
RHO1_SCHPOrho1genetic
11737264
RGF2_SCHPOrgf2genetic
16324155
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of RGA1_SCHPO

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Phosphoproteome analysis of fission yeast.";
Wilson-Grady J.T., Villen J., Gygi S.P.;
J. Proteome Res. 7:1088-1097(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-690, AND MASSSPECTROMETRY.

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