RBP9X_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RBP9X_DROME
• UniProt AC: Q4Z8K6
• Protein Name: Ran-binding proteins 9/10 homolog
• Gene Name: RanBPM
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 962
• Subcellular Localization: Cytoplasm . Membrane . Nucleus . Distribution varies depending on cell type and developmental stage. At late embryogenesis expression is enriched in the nuclei of follicle cells and germline cells and at the nurse cell membranes. In pupal ovaries, ex
• Protein Description: May be involved in JAK/STAT signaling. Isoform D is required for the proper arrangement of niche cells and is autonomously required for proper niche cell size, isoform C negatively regulates the adhesive properties of the niche. The germline stem cell (GSC) niche in ovaries is made up of two somatic cell types: 8-9 cells in a single-filed array make up the terminal filament (TF), and a tight cluster of 5 or 6 cap cells (CpC). Regulating the size and adhesive properties of the CpCs is an important component of the mechanism that controls their capacity to support stem cells, isoform C and isoform D are important factors in mediating this regulation. In contrast, isoform C acts as a positive regulator of cell adhesion in follicle cell epithelium..
• Protein Sequence: MENVEEAPPLSSESNSNSNNSSASSSSHQLSQSGAMGAEIAPSTSRSHSHSPTPSPPVPASSHDQPHPDHPSPPLNASETEARENSPHDHSPTPTFHQTAPPPTTSSTAPQRDEREQQQQQEAPPLQQDQQENSPAQDQELHPLLDQQNQEYPAVHQDQQAEQNQELHHIEGLIRHRESQNPEEHPPQASLENRETLGREDTNQEPDEPQVRDPEIEPEAEPPPPLLLEDLDEQDSGSQDLNEQQPPLIIDANAIAETIDANAVERIDDYEDDDEEVDEEEEVVEDRVDRAGEVASVSGAQRLHSVAVLPRYSSASRAPRSSNNNNNNISNHNNNNNNSNSNSLSRRTRHFYSNNGSHFSNDMFPSHNPRSSTQTSSPRVGGRRHHSTPAASSNSPQHQGVDPLRLLYPNVNESETPLPRCWSPHDKCLSIGLSQNNLRVTYKGVGKQHSDAASVRTAYPIPSSCGLYYFEVRIISKGRNGYMGIGLTAQQFRMNRLPGWDKQSYGYHGDDGNSFSSSGNGQTYGPTFTTGDVIGCCVNFVNNTCFYTKNGVDLGIAFRDLPTKLYPTVGLQTPGEEVDANFGQEPFKFDKIVDMMKEMRSNVLRKIDRYPHLLETPENLMNRLVSTYLVHNAFSKTAEAFNGYTNQTFNEDLASIKTRQKIIKLILTGKMSQAIEHTLRSFPGLLENNKNLWFALKCRQFIEMINGADIENVNNKVTATTQTMPTNQTSVIQSTKTFKHSKSGSGNGNVNINQTQQQNNTAIPAVIKPQGGDRPDIKNMLVDDNSNKCVEHDSNSMDVEMEPCQSHSNGGDSSSNGNASAVRNSLDAIDEEMDVDVSPSSRNCGRVIEKILEFGKELSSMGQQLEKENLMTEEERQMLEDAFSLIAYSNPWSSPLGWLLCPSRRESVSTTLNSAILESLNFERRPPLEYLVAHASELIKVIGQHSLGEDAFITIDDVFPQN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
305	Phosphorylation	SGAQRLHSVAVLPRY CCCCCEEEEEEEECC	19.16	21082442
371	Phosphorylation	FPSHNPRSSTQTSSP CCCCCCCCCCCCCCC	38.71	21082442
377	Phosphorylation	RSSTQTSSPRVGGRR CCCCCCCCCCCCCCC	21.80	30478224
387	Phosphorylation	VGGRRHHSTPAASSN CCCCCCCCCCCCCCC	29.93	19429919
388	Phosphorylation	GGRRHHSTPAASSNS CCCCCCCCCCCCCCC	16.76	19429919
392	Phosphorylation	HHSTPAASSNSPQHQ CCCCCCCCCCCCCCC	31.96	19429919
393	Phosphorylation	HSTPAASSNSPQHQG CCCCCCCCCCCCCCC	36.28	19429919
395	Phosphorylation	TPAASSNSPQHQGVD CCCCCCCCCCCCCCC	28.08	19429919
463 (in isoform 3)	Phosphorylation	-	38.69	19429919
474 (in isoform 3)	Phosphorylation	-	5.14	19429919
726	Phosphorylation	ATTQTMPTNQTSVIQ EEEEECCCCCCEEEE	29.18	21082442
730	Phosphorylation	TMPTNQTSVIQSTKT ECCCCCCEEEEEEEE	13.88	21082442
743	Phosphorylation	KTFKHSKSGSGNGNV EEEECCCCCCCCCCC	41.00	19429919
745	Phosphorylation	FKHSKSGSGNGNVNI EECCCCCCCCCCCCC	35.85	19429919
786	Phosphorylation	NMLVDDNSNKCVEHD HCEECCCCCCCEECC	44.66	19429919
825	Phosphorylation	NASAVRNSLDAIDEE CHHHHHHHHHHCCCC	19.64	19429919
825 (in isoform 2)	Phosphorylation	-	19.64	19429919
836 (in isoform 2)	Phosphorylation	-	30.80	19429919
838	Phosphorylation	EEMDVDVSPSSRNCG CCCCCCCCCCCCCHH	18.01	22668510

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RBP9X_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RBP9X_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RBP9X_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PUF68_DROME	pUf68	physical	14605208
IF4E_DROME	eIF-4E	physical	14605208
CADE_DROME	shg	genetic	18762575
WDR26_DROME	CG7611	physical	22036573

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Phosphoproteome analysis of Drosophila melanogaster embryos.";
Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
J. Proteome Res. 7:1675-1682(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-387; SER-393 ANDSER-395, AND MASS SPECTROMETRY.
PubMed: 18327897