RB33A_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RB33A_HUMAN
• UniProt AC: Q14088
• Protein Name: Ras-related protein Rab-33A
• Gene Name: RAB33A
• Organism: Homo sapiens (Human).
• Sequence Length: 237
• Subcellular Localization: Cell membrane ; Lipid-anchor ; Cytoplasmic side .
• Protein Sequence: MAQPILGHGSLQPASAAGLASLELDSSLDQYVQIRIFKIIVIGDSNVGKTCLTFRFCGGTFPDKTEATIGVDFREKTVEIEGEKIKVQVWDTAGQERFRKSMVEHYYRNVHAVVFVYDVTKMTSFTNLKMWIQECNGHAVPPLVPKVLVGNKCDLREQIQVPSNLALKFADAHNMLLFETSAKDPKESQNVESIFMCLACRLKAQKSLLYRDAERQQGKVQKLEFPQEANSKTSCPC

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
10	Phosphorylation	QPILGHGSLQPASAA CCCCCCCCCCCCCHH	20.39	24043423
15	Phosphorylation	HGSLQPASAAGLASL CCCCCCCCHHCHHHE	25.90	24043423
21	Phosphorylation	ASAAGLASLELDSSL CCHHCHHHEECCCCH	27.67	24043423
26	Phosphorylation	LASLELDSSLDQYVQ HHHEECCCCHHHHHE	45.48	24043423
27	Phosphorylation	ASLELDSSLDQYVQI HHEECCCCHHHHHEE	35.31	24043423
31	Phosphorylation	LDSSLDQYVQIRIFK CCCCHHHHHEEEEEE	8.25	24043423
77	Phosphorylation	GVDFREKTVEIEGEK ECEECEEEEEEECEE	20.72	22985185
101	Phosphorylation	GQERFRKSMVEHYYR CHHHHHHHHHHHHHH	24.65	28450419
152	Ubiquitination	PKVLVGNKCDLREQI CEEEECCCCCHHHHC	24.17	29967540
186	Acetylation	ETSAKDPKESQNVES ECCCCCHHHCCCHHH	78.94	26051181
207	Phosphorylation	CRLKAQKSLLYRDAE HHHHHHHHHHHHHHH	16.13	-
210	Phosphorylation	KAQKSLLYRDAERQQ HHHHHHHHHHHHHHC	16.25	-
222	Ubiquitination	RQQGKVQKLEFPQEA HHCCCEEECCCCHHH	53.63	29967540
235	Geranylgeranylation	EANSKTSCPC----- HHCCCCCCCC-----	4.89	-
237	Methylation	NSKTSCPC------- CCCCCCCC-------	11.61	-
237	Geranylgeranylation	NSKTSCPC------- CCCCCCCC-------	11.61	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RB33A_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RB33A_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RB33A_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PRAF1_HUMAN	RABAC1	physical	16189514
RTN3_HUMAN	RTN3	physical	16189514
RTN4_HUMAN	RTN4	physical	16189514
A16L1_HUMAN	ATG16L1	physical	18448665
PRAF1_HUMAN	RABAC1	physical	19060904
AR6P1_HUMAN	ARL6IP1	physical	25416956
CC136_HUMAN	CCDC136	physical	25416956

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.