PUP18_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PUP18_ARATH
• UniProt AC: Q9C508
• Protein Name: Probable purine permease 18
• Gene Name: PUP18
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 390
• Subcellular Localization: Membrane ; Multi-pass membrane protein .
• Protein Sequence: MEMTEASKQTTAEGSANPEPDQILSPRRSLELKQKKWWISVSLCIFLVLLGDSLVMLLLNFFYVQDNREDSDQDLQYRGTWLQALVQNAAFPLLIPLFFIFPSPKQNQETTNTRFLSFRLILLYISLGVLVAAHSKLFALGKLYANFGVFTLISATQLIFTAIFAAIINRFKFTRWIILSIIGSILIYVFGSPEFGGEPDENEEFYSIQAWLTFAASVAFALSLCLFQLCFEKVLVKTKRYGNKKVFRMVIEMQICVSFVATVVCLVGLFASGENKELQGDSHRFKKGETYYVLSLIGLALSWQVWAVGLMGLVLYVSGVFGDVVHMCTSPLVALFVVLAFDFMDDEFSWPRIGTLIATVVALGSYFYTLHKRNKKKMVELYQTENNIDV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
10	Phosphorylation	MTEASKQTTAEGSAN CCHHHCCCCCCCCCC	31.54	23776212
11	Phosphorylation	TEASKQTTAEGSANP CHHHCCCCCCCCCCC	21.88	23776212
15	Phosphorylation	KQTTAEGSANPEPDQ CCCCCCCCCCCCHHH	19.17	23776212
25	Phosphorylation	PEPDQILSPRRSLEL CCHHHCCCCCCCHHH	20.28	30291188

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PUP18_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PUP18_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PUP18_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
HHP4_ARATH	HHP4	physical	24833385
UBC34_ARATH	UBC34	physical	24833385
CLH1_ARATH	CLH1	physical	24833385
CNIH1_ARATH	AT3G12180	physical	24833385
WNK3_ARATH	WNK3	physical	24833385
CP21D_ARATH	AT3G66654	physical	24833385
SPCS1_ARATH	AT2G22425	physical	24833385
PAM74_ARATH	AT5G59650	physical	24833385
BETL2_ARATH	AT1G29060	physical	24833385
BET12_ARATH	ATBET12	physical	24833385

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Large-scale Arabidopsis phosphoproteome profiling reveals novelchloroplast kinase substrates and phosphorylation networks.";
Reiland S., Messerli G., Baerenfaller K., Gerrits B., Endler A.,Grossmann J., Gruissem W., Baginsky S.;
Plant Physiol. 150:889-903(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-25, AND MASSSPECTROMETRY.
PubMed: 19376835

"Phosphoproteomic analysis of nuclei-enriched fractions fromArabidopsis thaliana.";
Jones A.M.E., MacLean D., Studholme D.J., Serna-Sanz A.,Andreasson E., Rathjen J.P., Peck S.C.;
J. Proteomics 72:439-451(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-25, AND MASSSPECTROMETRY.
PubMed: 19245862

"Temporal analysis of sucrose-induced phosphorylation changes inplasma membrane proteins of Arabidopsis.";
Niittylae T., Fuglsang A.T., Palmgren M.G., Frommer W.B.,Schulze W.X.;
Mol. Cell. Proteomics 6:1711-1726(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-25, AND MASSSPECTROMETRY.
PubMed: 17586839

"Novel subsets of the Arabidopsis plasmalemma phosphoproteome identifyphosphorylation sites in secondary active transporters.";
Hem S., Rofidal V., Sommerer N., Rossignol M.;
Biochem. Biophys. Res. Commun. 363:375-380(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-25, AND MASSSPECTROMETRY.
PubMed: 17869214

"Phosphoproteomics of the Arabidopsis plasma membrane and a newphosphorylation site database.";
Nuehse T.S., Stensballe A., Jensen O.N., Peck S.C.;
Plant Cell 16:2394-2405(2004).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-25, AND MASSSPECTROMETRY.
PubMed: 15308754