| UniProt ID | PTR1_SCHPO | |
|---|---|---|
| UniProt AC | O13834 | |
| Protein Name | E3 ubiquitin-protein ligase ptr1 | |
| Gene Name | ptr1 | |
| Organism | Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast). | |
| Sequence Length | 3227 | |
| Subcellular Localization | Nucleus. | |
| Protein Description | Probable ubiquitin ligase protein involved in mRNA export. E3 ubiquitin ligase proteins mediate ubiquitination and subsequent proteasomal degradation of target proteins. Probably participates in mRNA export from the nucleus by regulating the transport of hnRNP proteins such as rae1.. | |
| Protein Sequence | MRITKSPPKNQYSQPPPRVAEFIRQAQNEEVTSDLGLVSLCSEFRKNDWPYPRGDLYSWVPVLNRFDAILERIVEHYSLKDKVQTKPFDSDTLSILLEILSFSAHLLSHCANRSIYNSTVYLEYLLNSSVLEVIDSTLALLLHIVQKATISKRGKQLFSLSQDRLFRFLMFLPQDAMKTGFSQNYETLLFSNEIPQEWCSLELSYYKSSPSKDFSSASQPNSEGFSILKLPYNKVLGKPIEELLVKTLHDNQIPEQYSFDLLVSLMLRQNLYDINRRRLMIRIGLLALSNLVYAHSQAVQTRFLIADPEITTHLANLVSPDVDLPQNFKAVCFECFKAFFFKKSMIPSVLASLNVSVSYGLMMNLVRDFSKNLENPNFYYEREYVDSFYDFLQFMTSSPLGGNMACSAGLTSLLGYHLSVKTPQATYVVARSIVMLDHLIDGYSMAFPDFSESKGLDMLVDRVQYELEAGLQDIKSGKGNPEIVLNMDYAISYDRYFLLKNLLKFVLHLIQSGGSVVELRNLIDSSLISSLAFLLEHHEVYGSNLFASTTNIMSTFIHNEPTCYGIIHEKKLSHAFLDAVNRKILNSSDAITSIPLAFGAICLNSQGFDLFLEKNPIPQLFSIFTSLNHCKSLISSDNAAILGTYIDELMRHQPSLKDPIVKMIFKACDQVSALLDNFNPFQYINAKEYPYLLYLETFSSFLENIITNEGHARYLISKGIVSHVLNLIQHPVLAFGFIDSSAFNSFFVLLHHAVDFDAPEVFRPLLDCIITRCEEGITEFTIVSLKQATISLIKDSNMGHEDANNFLHFSIVGNLLTIFAELFSSHAALKKAGNLPLVQLFISPSRYAGIFDILCNIKSIATSLDIHICLGVSDDFVLCSDSLTTIVTDKDEKEKFETKKKELTQDSSFCKFQNIRSNFSQIAYGVSKFFTSLTRALGNTSVQDFNEYKMIHKLGSNIALVVDELINLSSKQITSHPQSLSIASLEASLIFVLGASSIIREDDSKVTLVLLISRLLGGCRTMDVLISLNETVSGFFRLSDRDPLSKSNRVLLALSSTLLNLILVFTSADFMSETSKTLNMALKSEFDMTDFNNSGSKLMHVLHARIFISVLHLWRSADDLHLPYITRALLTNVLSNCYQFEDGIKNVVDSINNLRTSIANGDIKEPLDVVTDDNTNSNFSLEETNASVTDMPESEKHENGIFQAYLLKEMPNDIVSQFEMLKSKQIELTVQMASYEGDLNQNLCDFLYTRDDVQMNADVQFSVTSGLIVEIKKLAQSTDCKAKNQLGPAVGLLSLFISHDFTQNKAKNCVLSELNFFLELLHSLNNGLPSDSHKTSIVCILYLLEVLLADSKKPDEFEFNSEDCSLKLTDGAITVDLASQKHIMSSVITLLSLNSANLGVVVSAFRVVVLLTSASEMIHTFVKLSGLPSLFKAMRACSGFCNESLHIPFISILRRLLEFDEVVELMMFDDLVNIFKLQGRARKTELHGFIRANAEMVLRSPECFIKILKDCCVLGHFTPESEHYYLELKESLPGVLQNGQTDLDPSKEQMSSVIVSFLLDELMDLTETRQFSDRSPNSEFTPENDSLYMYNVFLLQCLTELLSGYNACKRCFLNFQPRRKAPFFNLSRKYNSYLVGFFLEKLLPFGCIRLSENNEVRKAFSVSNWAISILVFLCAYSNEQQTQAVDEIRREVLTSVLKFYKSSSSFSENLEAYYCKLLVLAELCYRLCDAQTVSQKAPNHLLRRSQDQNVKTMIDLGYIPTLTNAISEIDMNYPVSRKVVRHILKPLQLLTKEAIFLSQTNPEALSGAAQDSMGDQSLSSSSEESSDSDREEPPDLYRNSVLGIFQGDIVNENDENYEDSEDDGVYEEMEFEDDQSGSADSVVSEDDADDVMYSDNDDMNIEFMVDEQDASSQNDDSSFDEASSHGDVISIDEEDLDNQGEEFEWEDEDNASSGYEDELDYNEDEVGENDSTTFEAMENAFTETSDNDDHLEEADHVSPVEIDFLENDENSSSEQDDEFQWEWNTETPSGADILSRHGALLRDLFPLPGLSRRVMIINSNDPSRSRPFLNNNASEGLLKHPLLLRNNLIHTPKATELWENLAEIDNHTASGAAFQRLLYYLALEIPNEDSSVLGWTSLKVSKHTDPLRATSDFIPLFSMQRWNSITSMFFAHASGSIALRITGSVLFALVPPALEKYNLENQKKEILENESKEEETRQPEVNIQPEEPINTSDMEGVTTEANEIGSYQEPSLINIRGREVDVSSLGIDPTFLLALPEEMREEVVFQHIQERHMESISDSSRRIDPSFLEVLPSDLRDELLFQEAVQMRLFDHATRNNNSVDHEVEMEEIDQGGTVSEHREKSVKPVKKIPVPNLLDRQGLYSLIRLIFISQHNGKNPYYDLIVNISENKQHRADIVGLLLYILQEASINDRASEKCYRDLTVKSLNNSQQKEVKKSTGLLESLCKVPVVNGISAPALILQQGIDLLSHLATWADHFASFFLSMHDFSGIASKKSAGRKNRESNVYKIAPINVLLGLLAREELFGNTLVMNTFSELLSTLTKPLLSFYKSEKLQKDSATTGYTNDQDSRGSTVPKQDPGTTASRKDKKILSPPNILDENLRLAASLITTDSCSSRTFQNALSVMFHLSSIPKAKILIGKELLRHGQEYGNSITNDLSRLCADVKSGKNESELQVALAPFCPASSNQAKLLRCLKALDYIFERRPKGQEQSPGNIIQLLEFYDNLKFSSLWEVLSECLSALRDHTSITHVSTVLLPLIESLMVICRLVFIELPEDVGKHISPILERFKTLFISFTEEHRKIINMMVFTTPSLMSGSFSLLVKNPKVLEFENKRNYFNRQLHEEAAKEQYPPLNITVRRDHVFLDSYRALHFKDADEVKFSKLNIHFRDEEGVDAGGVTREWLQVLARQMFNPDYALFLPVTGDATTFHPNRDSSVNPDHLSFFKFTGRIIGKALYDGRLLDCHFSRAVYKHMLHRSVSVKDIESLDPDYYKSLVWMLNNDITDIITEEFAVEKDVFGEKTVVDLIPNGRNIPVTELNKQNYVNRMVDYKLRESVKDQLKSLLDGFSDIIPSHLIQIFNEQELELLISGLPEIDIDDWKNNTEYHGYNVSSPQVQWFWRAVRSFDEEERAKLLQFATGTSKVPLNGFKELEGMSGFQRFNIHKSYGSLNRLPQSHTCFNQLDLPEYDTYEQLRSMLLTAINEGSEGFGFA | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 2339 | Phosphorylation | HATRNNNSVDHEVEM HHHCCCCCCCCEEEH | 30.92 | 25720772 | |
| 2522 | Phosphorylation | AGRKNRESNVYKIAP CCCCCCCCCCCHHHH | 28.49 | 21712547 | |
| 2582 | Phosphorylation | DSATTGYTNDQDSRG CCCCCCCCCCCCCCC | 33.39 | 29996109 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of PTR1_SCHPO !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of PTR1_SCHPO !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of PTR1_SCHPO !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| MPD2_SCHPO | mpd2 | genetic | 15094387 | |
| RAE1_SCHPO | rae1 | genetic | 15094387 | |
| THI4_SCHPO | thi2 | genetic | 18201975 | |
| AGO1_SCHPO | ago1 | physical | 22989756 | |
| YBJC_SCHPO | red5 | genetic | 23658229 | |
| MIP1_SCHPO | mip1 | genetic | 24766403 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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