THI4_SCHPO - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: THI4_SCHPO
• UniProt AC: P40998
• Protein Name: Thiamine thiazole synthase {ECO:0000255|HAMAP-Rule:MF_03158}
• Gene Name: thi2
• Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
• Sequence Length: 328
• Subcellular Localization: Cytoplasm . Nucleus .
• Protein Description: Involved in biosynthesis of the thiamine precursor thiazole. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylic acid (ADT), an adenylated thiazole intermediate. The reaction includes an iron-dependent sulfide transfer from a conserved cysteine residue of the protein to a thiazole intermediate. The enzyme can only undergo a single turnover, which suggests it is a suicide enzyme. May have additional roles in adaptation to various stress conditions and in DNA damage tolerance..
• Protein Sequence: MAPATAVVTPQTAFKTDLPVEKTAHNTVVKSEMGALSKAYPTYSLDESFSFAPIRESTVSRAMTRRYFSDLDKYAESDIVIVGAGSAGLTAAYYIGTRRPDLKIAIIEASVAPGGGAWLGGQLFSAMVVRKPADLFLNEIGVPYEDEGDYVVVKHAALFTSTVMARTLALPNVKLFNATAVEDLIVKEGKDGKQRIAGVVTNWTLVSLNHGLQSCMDPNTINAHLVVSATGHDGPFGAFCVKRLASAQLVSNLHDMRPLDMNRAEDLIVKGTREVFPGMIVGGMELSEFDGANRMGPTFGGMMFSGIKAAQEALAIFDERKAVNEKYL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	Phosphorylation	---MAPATAVVTPQT ---CCCCEEEECCCC	20.94	24763107
9	Phosphorylation	APATAVVTPQTAFKT CCCEEEECCCCCCCC	11.77	24763107
12	Phosphorylation	TAVVTPQTAFKTDLP EEEECCCCCCCCCCC	34.95	29996109
16	Phosphorylation	TPQTAFKTDLPVEKT CCCCCCCCCCCCEEC	35.99	25720772
23	Phosphorylation	TDLPVEKTAHNTVVK CCCCCEECCCCHHHH	21.46	24763107
27	Phosphorylation	VEKTAHNTVVKSEMG CEECCCCHHHHHHHH	19.46	21712547
31	Phosphorylation	AHNTVVKSEMGALSK CCCHHHHHHHHHHHH	22.62	29996109
40	Phosphorylation	MGALSKAYPTYSLDE HHHHHHCCCCCCCCC	10.39	29996109
42	Phosphorylation	ALSKAYPTYSLDESF HHHHCCCCCCCCCCC	17.05	29996109
43	Phosphorylation	LSKAYPTYSLDESFS HHHCCCCCCCCCCCC	11.61	29996109
44	Phosphorylation	SKAYPTYSLDESFSF HHCCCCCCCCCCCCC	31.64	29996109
48	Phosphorylation	PTYSLDESFSFAPIR CCCCCCCCCCCCCCC	26.34	25720772
57	Phosphorylation	SFAPIRESTVSRAMT CCCCCCHHHHHHHHH	25.02	29996109
58	Phosphorylation	FAPIRESTVSRAMTR CCCCCHHHHHHHHHH	20.11	29996109
60	Phosphorylation	PIRESTVSRAMTRRY CCCHHHHHHHHHHHH	17.89	29996109
69	Phosphorylation	AMTRRYFSDLDKYAE HHHHHHHCCHHHHCC	28.47	25720772
215	Other	LNHGLQSCMDPNTIN CCCHHHHCCCCCCCC	2.01	-
246	Phosphorylation	FCVKRLASAQLVSNL HHHHHHHHHHHHHCC	22.57	25720772
251	Phosphorylation	LASAQLVSNLHDMRP HHHHHHHHCCHHCCC	42.12	29996109
287	Phosphorylation	IVGGMELSEFDGANR EECCEEHHHCCCCCC	23.94	25720772
327	Phosphorylation	RKAVNEKYL------ HHHHHHHCC------	16.09	25720772

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of THI4_SCHPO !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of THI4_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of THI4_SCHPO !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
THI4_SCHPO	thi2	physical	23695164
THI4_SCHPO	thi2	physical	26771498

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.