PPBN_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PPBN_HUMAN
• UniProt AC: P10696
• Protein Name: Alkaline phosphatase, placental-like
• Gene Name: ALPPL2
• Organism: Homo sapiens (Human).
• Sequence Length: 532
• Subcellular Localization: Cell membrane; Lipid-anchor, GPI-anchor.
• Protein Sequence: MQGPWVLLLLGLRLQLSLGIIPVEEENPDFWNRQAAEALGAAKKLQPAQTAAKNLIIFLGDGMGVSTVTAARILKGQKKDKLGPETFLAMDRFPYVALSKTYSVDKHVPDSGATATAYLCGVKGNFQTIGLSAAARFNQCNTTRGNEVISVMNRAKKAGKSVGVVTTTRVQHASPAGAYAHTVNRNWYSDADVPASARQEGCQDIATQLISNMDIDVILGGGRKYMFPMGTPDPEYPDDYSQGGTRLDGKNLVQEWLAKHQGARYVWNRTELLQASLDPSVTHLMGLFEPGDMKYEIHRDSTLDPSLMEMTEAALLLLSRNPRGFFLFVEGGRIDHGHHESRAYRALTETIMFDDAIERAGQLTSEEDTLSLVTADHSHVFSFGGYPLRGSSIFGLAPGKARDRKAYTVLLYGNGPGYVLKDGARPDVTESESGSPEYRQQSAVPLDGETHAGEDVAVFARGPQAHLVHGVQEQTFIAHVMAFAACLEPYTACDLAPRAGTTDAAHPGPSVVPALLPLLAGTLLLLGTATAP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
44	Ubiquitination	EALGAAKKLQPAQTA HHHHHHHHCCHHHHH	47.86	29967540
50	Phosphorylation	KKLQPAQTAAKNLII HHCCHHHHHHHCEEE	30.59	-
53	Ubiquitination	QPAQTAAKNLIIFLG CHHHHHHHCEEEEEC	50.23	29967540
99	Phosphorylation	RFPYVALSKTYSVDK CCCEEEEECEEEECC	17.14	29759185
101	Phosphorylation	PYVALSKTYSVDKHV CEEEEECEEEECCCC	20.04	29759185
102	Phosphorylation	YVALSKTYSVDKHVP EEEEECEEEECCCCC	15.50	29759185
103	Phosphorylation	VALSKTYSVDKHVPD EEEECEEEECCCCCC	29.13	29759185
111	Phosphorylation	VDKHVPDSGATATAY ECCCCCCCCCCEEEH	25.02	30266825
114	Phosphorylation	HVPDSGATATAYLCG CCCCCCCCEEEHHHC	28.24	30266825
116	Phosphorylation	PDSGATATAYLCGVK CCCCCCEEEHHHCCC	16.10	23663014
118	Phosphorylation	SGATATAYLCGVKGN CCCCEEEHHHCCCCC	9.73	30266825
123	Ubiquitination	TAYLCGVKGNFQTIG EEHHHCCCCCCEEEC	33.16	21963094
141	N-linked_Glycosylation	AARFNQCNTTRGNEV HHHHHCCCCCCCCHH	34.42	UniProtKB CARBOHYD
157	Ubiquitination	SVMNRAKKAGKSVGV HHHHHHHHCCCCEEE	62.48	29967540
160	Ubiquitination	NRAKKAGKSVGVVTT HHHHHCCCCEEEEEE	46.99	29967540
188	Phosphorylation	HTVNRNWYSDADVPA EECCCCCCCCCCCCH	10.54	-
196	Phosphorylation	SDADVPASARQEGCQ CCCCCCHHHHHCCHH	20.22	110739425
225	Phosphorylation	ILGGGRKYMFPMGTP EECCCCEEECCCCCC	11.57	74103177
231	Phosphorylation	KYMFPMGTPDPEYPD EEECCCCCCCCCCCC	20.47	110740529
236	Phosphorylation	MGTPDPEYPDDYSQG CCCCCCCCCCCCCCC	19.83	30576142
240	Phosphorylation	DPEYPDDYSQGGTRL CCCCCCCCCCCCCCC	15.41	74103173
241	Phosphorylation	PEYPDDYSQGGTRLD CCCCCCCCCCCCCCC	29.37	30576142
250	Ubiquitination	GGTRLDGKNLVQEWL CCCCCCCHHHHHHHH	46.93	22817900
268	N-linked_Glycosylation	QGARYVWNRTELLQA CCCCEEECHHHHHHH	30.84	UniProtKB CARBOHYD
301	Phosphorylation	KYEIHRDSTLDPSLM CEEEECCCCCCHHHH	30.72	22468782
306	Phosphorylation	RDSTLDPSLMEMTEA CCCCCCHHHHHHHHH	39.76	22468782
311	Phosphorylation	DPSLMEMTEAALLLL CHHHHHHHHHHHHHH	14.79	22468782
319	Phosphorylation	EAALLLLSRNPRGFF HHHHHHHHCCCCCEE	29.95	28355574
364	Phosphorylation	IERAGQLTSEEDTLS HHHHCCCCCCCCCEE	26.63	110739455
365	Phosphorylation	ERAGQLTSEEDTLSL HHHCCCCCCCCCEEE	47.80	110740537
369	Phosphorylation	QLTSEEDTLSLVTAD CCCCCCCCEEEEECC	22.86	110739465
374	Phosphorylation	EDTLSLVTADHSHVF CCCEEEEECCCCCEE	31.49	110740545
391	Phosphorylation	GGYPLRGSSIFGLAP CCEECCCCCCCCCCC	17.52	23663014
392	Phosphorylation	GYPLRGSSIFGLAPG CEECCCCCCCCCCCC	25.43	23663014
400	Ubiquitination	IFGLAPGKARDRKAY CCCCCCCCCCCCCCE	38.91	29967540
405	Ubiquitination	PGKARDRKAYTVLLY CCCCCCCCCEEEEEE	50.46	29967540
407	Phosphorylation	KARDRKAYTVLLYGN CCCCCCCEEEEEECC	10.62	110739477
408	Phosphorylation	ARDRKAYTVLLYGNG CCCCCCEEEEEECCC	14.99	110739483
412	Phosphorylation	KAYTVLLYGNGPGYV CCEEEEEECCCCCEE	12.37	20068231
418	Phosphorylation	LYGNGPGYVLKDGAR EECCCCCEEECCCCC	13.02	20068231
421	Ubiquitination	NGPGYVLKDGARPDV CCCCEEECCCCCCCC	44.03	21963094
429	Phosphorylation	DGARPDVTESESGSP CCCCCCCCCCCCCCH	40.97	23663014
431	Phosphorylation	ARPDVTESESGSPEY CCCCCCCCCCCCHHH	27.91	23663014
433	Phosphorylation	PDVTESESGSPEYRQ CCCCCCCCCCHHHHC	54.58	23663014
435	Phosphorylation	VTESESGSPEYRQQS CCCCCCCCHHHHCCC	24.68	76974987
438	Phosphorylation	SESGSPEYRQQSAVP CCCCCHHHHCCCCCC	19.67	110740561
503	GPI-anchor	APRAGTTDAAHPGPS CCCCCCCCCCCCCCC	41.41	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PPBN_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PPBN_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PPBN_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PPB1_HUMAN	ALPP	physical	28514442
UBP16_HUMAN	USP16	physical	28514442
PPBI_HUMAN	ALPI	physical	28514442
PCOC2_HUMAN	PCOLCE2	physical	28514442
B3GLT_HUMAN	B3GALTL	physical	28514442
GALNS_HUMAN	GALNS	physical	28514442
AHNK_HUMAN	AHNAK	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.