PMA8_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PMA8_ARATH
• UniProt AC: Q9M2A0
• Protein Name: ATPase 8, plasma membrane-type
• Gene Name: AHA8
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 948
• Subcellular Localization: Membrane; Multi-pass membrane protein.
• Protein Description: The plasma membrane H(+) ATPase of plants and fungi generates a proton gradient that drives the active transport of nutrients by H(+)-symport. The resulting external acidification and/or internal alkinization may mediate growth responses (By similarity)..
• Protein Sequence: MATEFSWDEIKKENVDLERIPVEEVFEQLKCSKEGLSSDEGAKRLEIFGANKLEEKSENKFLKFLGFMWNPLSWVMESAAIMAIVLANGGGKAPDWQDFIGIMVLLIINSTISFIEENNAGNAAAALMANLAPKTKVLRDGKWGEQEASILVPGDLISIKLGDIVPADARLLEGDPLKIDQSALTGESLPTTKHPGDEVFSGSTCKQGEIEAVVIATGVHTFFGKAAHLVDSTNNVGHFQKVLTSIGNFCICSIGLGMLIEILIMYPIQHRTYRDGIDNLLVLLIGGIPIAMPTVLSVTMAIGSHRLSQQGAITKRMTAIEEMAGMDVLCSDKTGTLTLNKLSVDKSLIEVFPKNMDSDSVVLMAARASRIENQDAIDASIVGMLGDPKEARAGITEVHFLPFNPVDKRTAITYIDESGDWHRSSKGAPEQIIELCNLQGETKRKAHEVIDGFAERGLRSLGVAQQTVPEKTKESDGSPWEFVGLLPLFDPPRHDSAETIRRALELGVNVKMITGDQLAIGIETGRRLGMGTNMYPSTSLLGNSKDESLVGIPIDELIEKADGFAGVFPEHKYEIVKKLQERKHICGMTGDGVNDAPALKKADIGIAVADATDAARSASDIVLTEPGLSVIISAVLTSRAIFQRMKNYTIYAVSITIRIVLGFMLVALIWRFDFAPFMVLIIAILNDGTIMTISKDRVKPSPVPDSWKLNEIFATGVVLGTYMALTTVLFFWLAHDTDFFSKTFGVRSIQGNEEELMAALYLQVSIISQALIFVTRSRSWSFVERPGFLLLIAFVIAQLVATLIAVYANWGFARIVGCGWGWAGGIWVYSIITYIPLDILKFIIRYALTGKAWDNMINQKTAFTTKKDYGKGEREAQWALAQRTLHGLPPPEAMFNDNKNELSEIAEQAKRRAEVARLRELHTLKGHVESVVKLKGLDIDTIQQHYTV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
272	Phosphorylation	MYPIQHRTYRDGIDN HCCCCCCCCCCCHHH	22.30	15308754
294	Phosphorylation	GIPIAMPTVLSVTMA CCCCCCHHHHHHHHH	22.46	15308754
304	Phosphorylation	SVTMAIGSHRLSQQG HHHHHHCCHHHHHCC	10.18	29797451
318	Phosphorylation	GAITKRMTAIEEMAG CCHHHHHHHHHHHHC	28.63	19880383
331	Phosphorylation	AGMDVLCSDKTGTLT HCCCEEECCCCCCEE	37.67	19880383
343	Phosphorylation	TLTLNKLSVDKSLIE CEEECCCCCCHHHHH	29.85	19880383
347	Phosphorylation	NKLSVDKSLIEVFPK CCCCCCHHHHHHCCC	30.07	19880383
514	Phosphorylation	GVNVKMITGDQLAIG CCCEEEECCCEEEEE	31.07	17317660
524	Phosphorylation	QLAIGIETGRRLGMG EEEEECCCCCCCCCC	33.78	19880383
884	Phosphorylation	QWALAQRTLHGLPPP HHHHHHHHHCCCCCC	15.83	-
903	Phosphorylation	NDNKNELSEIAEQAK CCCHHHHHHHHHHHH	22.30	17317660
930	Phosphorylation	TLKGHVESVVKLKGL HHHCHHHEEEEECCC	30.99	17483306
947	Phosphorylation	DTIQQHYTV------ HHHHHHCCC------	20.02	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PMA8_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PMA8_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PMA8_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
HHP2_ARATH	HHP2	physical	24833385
HHP4_ARATH	HHP4	physical	24833385
UBC34_ARATH	UBC34	physical	24833385
UBC32_ARATH	UBC32	physical	24833385
SUB_ARATH	SUB	physical	24833385
CNIH1_ARATH	AT3G12180	physical	24833385
CP21D_ARATH	AT3G66654	physical	24833385
SPCS1_ARATH	AT2G22425	physical	24833385
BET12_ARATH	ATBET12	physical	24833385

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Large-scale analysis of in vivo phosphorylated membrane proteins byimmobilized metal ion affinity chromatography and mass spectrometry.";
Nuehse T.S., Stensballe A., Jensen O.N., Peck S.C.;
Mol. Cell. Proteomics 2:1234-1243(2003).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-903, AND MASSSPECTROMETRY.
PubMed: 14506206