| UniProt ID | PI2R_MOUSE | |
|---|---|---|
| UniProt AC | P43252 | |
| Protein Name | Prostacyclin receptor | |
| Gene Name | Ptgir | |
| Organism | Mus musculus (Mouse). | |
| Sequence Length | 415 | |
| Subcellular Localization |
Cell membrane Multi-pass membrane protein. |
|
| Protein Description | Receptor for prostacyclin (prostaglandin I2 or PGI2). The activity of this receptor is mediated by G(s) proteins which activate adenylate cyclase.. | |
| Protein Sequence | MMASDGHPGPPSVTPGSPLSAGGREWQGMAGSCWNITYVQDSVGPATSTLMFVAGVVGNGLALGILGARRRSHPSAFAVLVTGLAVTDLLGTCFLSPAVFVAYARNSSLLGLAHGGTMLCDTFAFAMTFFGLASTLILFAMAVERCLALSHPYLYAQLDGPRCARFALPSIYAFCCLFCSLPLLGLGEHQQYCPGSWCFIRMRSAQPGGCAFSLAYASLMALLVTSIFFCNGSVTLSLYHMYRQQRRHHGSFVPTSRAREDEVYHLILLALMTVIMAVCSLPLMIRGFTQAIAPDSREMGDLLAFRFNAFNPILDPWVFILFRKAVFQRLKFWLCCLCARSVHGDLQAPLSRPASGRRDPPAPTSLQAKEGSWVPLSSWGTGQVAPLTAVPLTGGDGCSVGMPSKSEAIAACSLC | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 35 | N-linked_Glycosylation | GMAGSCWNITYVQDS CCCCCCEEEEEEECC | 22.50 | - | |
| 335 | S-palmitoylation | QRLKFWLCCLCARSV HHHHHHHHHHHHHHH | 0.91 | - | |
| 338 | S-palmitoylation | KFWLCCLCARSVHGD HHHHHHHHHHHHCCC | 1.52 | - | |
| 351 | Phosphorylation | GDLQAPLSRPASGRR CCCCCCCCCCCCCCC | 34.85 | 29176673 | |
| 355 | Phosphorylation | APLSRPASGRRDPPA CCCCCCCCCCCCCCC | 35.20 | 11443126 | |
| 365 | Phosphorylation | RDPPAPTSLQAKEGS CCCCCCCCEEECCCC | 19.88 | 27742792 | |
| 404 | Phosphorylation | GCSVGMPSKSEAIAA CCCCCCCCHHHHHHH | 39.66 | 29899451 | |
| 412 | Methylation | KSEAIAACSLC---- HHHHHHHHCCC---- | 2.06 | - | |
| 412 | Farnesylation | KSEAIAACSLC---- HHHHHHHHCCC---- | 2.06 | 10446129 | |
| 412 | Farnesylation | KSEAIAACSLC---- HHHHHHHHCCC---- | 2.06 | 10446129 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of PI2R_MOUSE !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of PI2R_MOUSE !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of PI2R_MOUSE !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| GNAS2_MOUSE | Gnas | physical | 11443126 | |
| ALEX_MOUSE | Gnas | physical | 11443126 | |
| GNAS1_MOUSE | Gnas | physical | 11443126 | |
| GNAS3_MOUSE | Gnas | physical | 11443126 | |
| GNAI1_MOUSE | Gnai1 | physical | 11443126 | |
| GNA11_MOUSE | Gna11 | physical | 11443126 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Prenylation | |
| Reference | PubMed |
| "The prostacyclin receptor is isoprenylated. Isoprenylation isrequired for efficient receptor-effector coupling."; Hayes J.S., Lawler O.A., Walsh M.T., Kinsella B.T.; J. Biol. Chem. 274:23707-23718(1999). Cited for: ISOPRENYLATION AT CYS-412, AND MUTAGENESIS OF CYS-412. | |
