PDYN_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PDYN_HUMAN
• UniProt AC: P01213
• Protein Name: Proenkephalin-B
• Gene Name: PDYN
• Organism: Homo sapiens (Human).
• Sequence Length: 254
• Subcellular Localization: Secreted.
• Protein Description: Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress (By similarity).; Dynorphin peptides differentially regulate the kappa opioid receptor. Dynorphin A(1-13) has a typical opiod activity, it is 700 times more potent than Leu-enkephalin (By similarity).; Leumorphin has a typical opiod activity and may have anti-apoptotic effect..
• Protein Sequence: MAWQGLVLAACLLMFPSTTADCLSRCSLCAVKTQDGPKPINPLICSLQCQAALLPSEEWERCQSFLSFFTPSTLGLNDKEDLGSKSVGEGPYSELAKLSGSFLKELEKSKFLPSISTKENTLSKSLEEKLRGLSDGFREGAESELMRDAQLNDGAMETGTLYLAEEDPKEQVKRYGGFLRKYPKRSSEVAGEGDGDSMGHEDLYKRYGGFLRRIRPKLKWDNQKRYGGFLRRQFKVVTRSQEDPNAYSGELFDA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
99	Phosphorylation	YSELAKLSGSFLKEL HHHHHHHHHHHHHHH	31.52	23186163
101	Phosphorylation	ELAKLSGSFLKELEK HHHHHHHHHHHHHHH	24.83	26055452
108	Acetylation	SFLKELEKSKFLPSI HHHHHHHHCCCCCCC	72.13	7935039
116	Phosphorylation	SKFLPSISTKENTLS CCCCCCCCCCCCHHC	37.45	22985185
117	Phosphorylation	KFLPSISTKENTLSK CCCCCCCCCCCHHCH	40.48	22985185
118	Acetylation	FLPSISTKENTLSKS CCCCCCCCCCHHCHH	42.02	20167786

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PDYN_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PDYN_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PDYN_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049
TIM13_HUMAN	TIMM13	physical	26186194
ACD11_HUMAN	ACAD11	physical	26186194
TIM8B_HUMAN	TIMM8B	physical	26186194
S10AA_HUMAN	S100A10	physical	26186194
GNPTG_HUMAN	GNPTG	physical	26186194
GNPTA_HUMAN	GNPTAB	physical	26186194
ACD11_HUMAN	ACAD11	physical	28514442
TIM8B_HUMAN	TIMM8B	physical	28514442
TIM13_HUMAN	TIMM13	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 610245: Spinocerebellar ataxia 23 (SCA23)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.