dbPTM

NYAP2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	NYAP2_HUMAN
UniProt AC	Q9P242
Protein Name	Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 2
Gene Name	NYAP2
Organism	Homo sapiens (Human).
Sequence Length	653
Subcellular Localization
Protein Description	Activates PI3K and concomitantly recruits the WAVE1 complex to the close vicinity of PI3K and regulates neuronal morphogenesis..
Protein Sequence	MISSKMMSSNPEEDPLDTFLQYIEDMGMKAYDGLVIQNASDIARENDRLRNETNLAYLKEKNEKRRRQEEAIKRIGGEVGRGHEGSYVGKHFRMGFMTMPAPQDRLPHPCSSGFSVRSQSLHSVGGTDDDSSCGSRRQPPPKPKRDPSTKLSTSSETVSSTAASKSGKTPERTEASAKPRPHSDEYSKKIPPPKPKRNPNTQLSTSFDETYIKKHGPRRTSLPRDSSLSQMGSPAGDPEEEEPVYIEMVGNILRDFRKEDDDQSEAVYEEMKYPIFDDLGQDAKCDFDHHSCSSQCATPTVPDLDFAKASVPCPPKGLLCDIPPPFPNLLSHRPPLLVFPPAPVHCSPNSDESPLTPLEVTKLPVLENVSYMKQPAGASPSTLPSHVPGHAKLEKEQAAALGPASATPALSSSPPPPSTLYRTQSPHGYPKSHSTSPSPVSMGRSLTPLSLKRPPPYDAVHSGSLSRSSPSVPHSTPRPVSQDGAKMVNAAVNTYGAAPGGSRSRTPTSPLEELTSLFSSGRSLLRKSSSGRRSKEPAEKSTEELKVRSHSTEPLPKLDNKERGHHGASSSREPVKAQEWDGTPGTPVVTSRLGRCSVSPTLLAGNHSSEPKVSCKLGRSASTSGVPPPSVTPLRQSSDLQQSQVPSSLANRD

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Phosphorylation	-----MISSKMMSSN -----CCCHHCCCCC	23.70	29759185
31	Phosphorylation	EDMGMKAYDGLVIQN HHCCCCCCCCEEEEC	12.67	-
81	Methylation	RIGGEVGRGHEGSYV HHCCCCCCCCCCCCC	48.77	-
111	Phosphorylation	DRLPHPCSSGFSVRS CCCCCCCCCCCEEEC	37.64	-
120	Phosphorylation	GFSVRSQSLHSVGGT CCEEECCCCCCCCCC	29.33	-
148	Phosphorylation	PKPKRDPSTKLSTSS CCCCCCCCCCCCCCC	42.32	30576142
149	Phosphorylation	KPKRDPSTKLSTSSE CCCCCCCCCCCCCCC	41.20	30576142
150	Ubiquitination	PKRDPSTKLSTSSET CCCCCCCCCCCCCCC	44.79	29967540
152	Phosphorylation	RDPSTKLSTSSETVS CCCCCCCCCCCCCHH	28.00	27732954
153	Phosphorylation	DPSTKLSTSSETVSS CCCCCCCCCCCCHHH	46.86	25159151
154	Phosphorylation	PSTKLSTSSETVSST CCCCCCCCCCCHHHH	23.85	30576142
155	Phosphorylation	STKLSTSSETVSSTA CCCCCCCCCCHHHHH	37.06	30576142
157	Phosphorylation	KLSTSSETVSSTAAS CCCCCCCCHHHHHHH	27.86	-
159	Phosphorylation	STSSETVSSTAASKS CCCCCCHHHHHHHHC	29.41	24719451
161	Phosphorylation	SSETVSSTAASKSGK CCCCHHHHHHHHCCC	20.80	30576142
164	Phosphorylation	TVSSTAASKSGKTPE CHHHHHHHHCCCCCC	25.53	21712546
169	Phosphorylation	AASKSGKTPERTEAS HHHHCCCCCCCCCCC	33.63	21712546
173	Phosphorylation	SGKTPERTEASAKPR CCCCCCCCCCCCCCC	33.95	24719451
183	Phosphorylation	SAKPRPHSDEYSKKI CCCCCCCCHHHHCCC	34.52	25159151
186	Phosphorylation	PRPHSDEYSKKIPPP CCCCCHHHHCCCCCC	30.68	29083192
187	Phosphorylation	RPHSDEYSKKIPPPK CCCCHHHHCCCCCCC	25.98	29083192
204	Phosphorylation	RNPNTQLSTSFDETY CCCCCCCCCCCCHHH	16.52	23663014
205	Phosphorylation	NPNTQLSTSFDETYI CCCCCCCCCCCHHHH	41.84	23663014
206	Phosphorylation	PNTQLSTSFDETYIK CCCCCCCCCCHHHHH	27.59	25159151
210	Phosphorylation	LSTSFDETYIKKHGP CCCCCCHHHHHHHCC	32.18	23663014
211	Phosphorylation	STSFDETYIKKHGPR CCCCCHHHHHHHCCC	14.54	23663014
229	Phosphorylation	LPRDSSLSQMGSPAG CCCCCCHHHCCCCCC	21.77	27642862
233	Phosphorylation	SSLSQMGSPAGDPEE CCHHHCCCCCCCCHH	13.26	18669648
245	Phosphorylation	PEEEEPVYIEMVGNI CHHCCCCEEEEEHHH	11.24	21946561
257	Phosphorylation	GNILRDFRKEDDDQS HHHHHHHHHCCCCHH	45.82	18669648
264	Phosphorylation	RKEDDDQSEAVYEEM HHCCCCHHHHHHHHH	34.22	27642862
268	Phosphorylation	DDQSEAVYEEMKYPI CCHHHHHHHHHCCCC	17.14	21946561
273	Phosphorylation	AVYEEMKYPIFDDLG HHHHHHCCCCCCCCC	10.55	27642862
294	Phosphorylation	FDHHSCSSQCATPTV CCCCCCCCCCCCCCC	33.34	21712546
298	Phosphorylation	SCSSQCATPTVPDLD CCCCCCCCCCCCCCC	27.41	21712546
356	Phosphorylation	NSDESPLTPLEVTKL CCCCCCCCCCCCEEC	29.25	-
371	Phosphorylation	PVLENVSYMKQPAGA CEEECCCCCCCCCCC	12.21	27642862
379	Phosphorylation	MKQPAGASPSTLPSH CCCCCCCCCCCCCCC	20.61	25159151
411	Phosphorylation	ASATPALSSSPPPPS CCCCHHHCCCCCCCC	30.76	23663014
412	Phosphorylation	SATPALSSSPPPPST CCCHHHCCCCCCCCC	47.95	23663014
413	Phosphorylation	ATPALSSSPPPPSTL CCHHHCCCCCCCCCC	37.74	23663014
418	Phosphorylation	SSSPPPPSTLYRTQS CCCCCCCCCCCCCCC	36.50	23663014
419	Phosphorylation	SSPPPPSTLYRTQSP CCCCCCCCCCCCCCC	33.32	30175587
421	Phosphorylation	PPPPSTLYRTQSPHG CCCCCCCCCCCCCCC	16.23	27732954
425	Phosphorylation	STLYRTQSPHGYPKS CCCCCCCCCCCCCCC	20.46	25159151
432	Phosphorylation	SPHGYPKSHSTSPSP CCCCCCCCCCCCCCC	20.40	27732954
434	Phosphorylation	HGYPKSHSTSPSPVS CCCCCCCCCCCCCCC	37.36	18669648
435	Phosphorylation	GYPKSHSTSPSPVSM CCCCCCCCCCCCCCC	38.95	27732954
436	Phosphorylation	YPKSHSTSPSPVSMG CCCCCCCCCCCCCCC	26.79	18669648
438	Phosphorylation	KSHSTSPSPVSMGRS CCCCCCCCCCCCCCC	37.39	18669648
441	Phosphorylation	STSPSPVSMGRSLTP CCCCCCCCCCCCCCC	20.92	29759185
445	Phosphorylation	SPVSMGRSLTPLSLK CCCCCCCCCCCCCCC	30.76	23186163
447	Phosphorylation	VSMGRSLTPLSLKRP CCCCCCCCCCCCCCC	24.35	21815630
450	Phosphorylation	GRSLTPLSLKRPPPY CCCCCCCCCCCCCCC	32.80	23403867
458	Phosphorylation	LKRPPPYDAVHSGSL CCCCCCCCCCCCCCC	48.14	18669648
460	Phosphorylation	RPPPYDAVHSGSLSR CCCCCCCCCCCCCCC	3.18	18669648
462	O-linked_Glycosylation	PPYDAVHSGSLSRSS CCCCCCCCCCCCCCC	24.39	30059200
462	Phosphorylation	PPYDAVHSGSLSRSS CCCCCCCCCCCCCCC	24.39	18669648
464	Phosphorylation	YDAVHSGSLSRSSPS CCCCCCCCCCCCCCC	26.62	25159151
468	Phosphorylation	HSGSLSRSSPSVPHS CCCCCCCCCCCCCCC	43.13	25159151
469	Phosphorylation	SGSLSRSSPSVPHST CCCCCCCCCCCCCCC	21.78	25159151
471	Phosphorylation	SLSRSSPSVPHSTPR CCCCCCCCCCCCCCC	50.67	21712546
475	Phosphorylation	SSPSVPHSTPRPVSQ CCCCCCCCCCCCCCC	33.75	25159151
476	Phosphorylation	SPSVPHSTPRPVSQD CCCCCCCCCCCCCCC	21.93	25159151
481	Phosphorylation	HSTPRPVSQDGAKMV CCCCCCCCCCHHHHH	25.82	-
494	Phosphorylation	MVNAAVNTYGAAPGG HHHHHHHHCCCCCCC	19.41	29978859
495	Phosphorylation	VNAAVNTYGAAPGGS HHHHHHHCCCCCCCC	10.28	25884760
502	Phosphorylation	YGAAPGGSRSRTPTS CCCCCCCCCCCCCCC	32.76	28555341
504	Phosphorylation	AAPGGSRSRTPTSPL CCCCCCCCCCCCCHH	42.05	27732954
506	Phosphorylation	PGGSRSRTPTSPLEE CCCCCCCCCCCHHHH	31.97	23663014
508	Phosphorylation	GSRSRTPTSPLEELT CCCCCCCCCHHHHHH	42.22	26055452
509	Phosphorylation	SRSRTPTSPLEELTS CCCCCCCCHHHHHHH	28.79	26055452
523	Phosphorylation	SLFSSGRSLLRKSSS HHHHHHHHHHHHCCC	34.97	24719451
528	Phosphorylation	GRSLLRKSSSGRRSK HHHHHHHCCCCCCCC	24.25	22210691
529	Phosphorylation	RSLLRKSSSGRRSKE HHHHHHCCCCCCCCC	39.59	24719451
530	Phosphorylation	SLLRKSSSGRRSKEP HHHHHCCCCCCCCCC	43.33	18220336
532	Phosphorylation	LRKSSSGRRSKEPAE HHHCCCCCCCCCCCH	41.46	18669648
533	Phosphorylation	RKSSSGRRSKEPAEK HHCCCCCCCCCCCHH	56.45	18220336
551	Phosphorylation	ELKVRSHSTEPLPKL HHHHCCCCCCCCCCC	35.39	30576142
552	Phosphorylation	LKVRSHSTEPLPKLD HHHCCCCCCCCCCCC	35.88	30576142
591	Phosphorylation	PGTPVVTSRLGRCSV CCCCEEECCCCCCEE	17.56	24719451
597	Phosphorylation	TSRLGRCSVSPTLLA ECCCCCCEECCEEEC	25.03	30576142
599	Phosphorylation	RLGRCSVSPTLLAGN CCCCCEECCEEECCC	8.89	28387310
601	Phosphorylation	GRCSVSPTLLAGNHS CCCEECCEEECCCCC	27.22	29214152
608	Phosphorylation	TLLAGNHSSEPKVSC EEECCCCCCCCCEEE	40.16	24719451
614	Phosphorylation	HSSEPKVSCKLGRSA CCCCCCEEEEECCCC	16.20	24719451
620	Phosphorylation	VSCKLGRSASTSGVP EEEEECCCCCCCCCC	25.44	18669648
622	Phosphorylation	CKLGRSASTSGVPPP EEECCCCCCCCCCCC	25.09	30619164
623	Phosphorylation	KLGRSASTSGVPPPS EECCCCCCCCCCCCC	29.26	30619164
624	Phosphorylation	LGRSASTSGVPPPSV ECCCCCCCCCCCCCC	34.99	30619164
630	Phosphorylation	TSGVPPPSVTPLRQS CCCCCCCCCCCCCCC	44.38	-
632	Phosphorylation	GVPPPSVTPLRQSSD CCCCCCCCCCCCCHH	22.42	28555341
644	Phosphorylation	SSDLQQSQVPSSLAN CHHHHHHCCCHHHHC	46.96	18669648
647	Phosphorylation	LQQSQVPSSLANRD- HHHHCCCHHHHCCC-	38.84	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of NYAP2_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of NYAP2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of NYAP2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MORN4_HUMAN	MORN4	physical	25416956
NCKP1_HUMAN	NCKAP1	physical	21946561
CYFP2_HUMAN	CYFIP2	physical	21946561
CYFP1_HUMAN	CYFIP1	physical	21946561
P85A_HUMAN	PIK3R1	physical	21946561
RHG26_HUMAN	ARHGAP26	physical	21946561
ACOT9_HUMAN	ACOT9	physical	21946561
WASF1_HUMAN	WASF1	physical	21946561

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of NYAP2_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-434; SER-436 ANDSER-438, AND MASS SPECTROMETRY.	18669648 [Abstract]
"Combining protein-based IMAC, peptide-based IMAC, and MudPIT forefficient phosphoproteomic analysis."; Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D.,Yates J.R. III; J. Proteome Res. 7:1346-1351(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-506 AND SER-509, ANDMASS SPECTROMETRY.	18220336 [Abstract]