NEUL1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NEUL1_HUMAN
• UniProt AC: O76050
• Protein Name: E3 ubiquitin-protein ligase NEURL1
• Gene Name: NEURL1
• Organism: Homo sapiens (Human).
• Sequence Length: 574
• Subcellular Localization: Cytoplasm, perinuclear region . Cell membrane; Peripheral membrane protein. Perikaryon. Cell projection, dendrite. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Localized in the cell bodies of the pyramidal neurons and dis
• Protein Description: Plays a role in hippocampal-dependent synaptic plasticity, learning and memory. Involved in the formation of spines and functional synaptic contacts by modulating the translational activity of the cytoplasmic polyadenylation element-binding protein CPEB3. Promotes ubiquitination of CPEB3, and hence induces CPEB3-dependent mRNA translation activation of glutamate receptor GRIA1 and GRIA2. Can function as an E3 ubiquitin-protein ligase to activate monoubiquitination of JAG1 (in vitro), thereby regulating the Notch pathway. Acts as a tumor suppressor; inhibits malignant cell transformation of medulloblastoma (MB) cells by inhibiting the Notch signaling pathway..
• Protein Sequence: MGNNFSSIPSLPRGNPSRAPRGHPQNLKDSIGGPFPVTSHRCHHKQKHCPAVLPSGGLPATPLLFHPHTKGSQILMDLSHKAVKRQASFCNAITFSNRPVLIYEQVRLKITKKQCCWSGALRLGFTSKDPSRIHPDSLPKYACPDLVSQSGFWAKALPEEFANEGNIIAFWVDKKGRVFHRINDSAVMLFFSGVRTADPLWALVDVYGLTRGVQLLDSELVLPDCLRPRSFTALRRPSLRREADDARLSVSLCDLNVPGADGDEAAPAAGCPIPQNSLNSQHSRALPAQLDGDLRFHALRAGAHVRILDEQTVARVEHGRDERALVFTSRPVRVAETIFVKVTRSGGARPGALSFGVTTCDPGTLRPADLPFSPEALVDRKEFWAVCRVPGPLHSGDILGLVVNADGELHLSHNGAAAGMQLCVDASQPLWMLFGLHGTITQIRILGSTILAERGIPSLPCSPASTPTSPSALGSRLSDPLLSTCSSGPLGSSAGGTAPNSPVSLPESPVTPGLGQWSDECTICYEHAVDTVIYTCGHMCLCYACGLRLKKALHACCPICRRPIKDIIKTYRSS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Myristoylation	------MGNNFSSIP ------CCCCCCCCC		-
230	Phosphorylation	PDCLRPRSFTALRRP CCCCCCCCCCCCCCH		24719451
337	Phosphorylation	RPVRVAETIFVKVTR CCEEEEEEEEEEEEC		28348404
343	Phosphorylation	ETIFVKVTRSGGARP EEEEEEEECCCCCCC		28348404
358	Phosphorylation	GALSFGVTTCDPGTL CCEEECEEECCCCCC		28348404
359	Phosphorylation	ALSFGVTTCDPGTLR CEEECEEECCCCCCC		28348404
364	Phosphorylation	VTTCDPGTLRPADLP EEECCCCCCCCCCCC		28348404
449	Phosphorylation	QIRILGSTILAERGI EEEECCHHHHHHCCC		27732954
468	Phosphorylation	CSPASTPTSPSALGS CCCCCCCCCHHHHCC		22210691
469	Phosphorylation	SPASTPTSPSALGSR CCCCCCCCHHHHCCC		28348404
471	Phosphorylation	ASTPTSPSALGSRLS CCCCCCHHHHCCCCC		22210691
565	Ubiquitination	PICRRPIKDIIKTYR HHHCCCHHHHHHHHH		-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NEUL1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NEUL1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NEUL1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
JAG1_HUMAN	JAG1	physical	18077452
UB2D1_HUMAN	UBE2D1	physical	18077452
ARFP2_HUMAN	ARFIP2	physical	26344197
JAG1_RAT	Jag1	physical	26276215
APBB1_HUMAN	APBB1	physical	26276215

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.