JAG1_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: JAG1_RAT
• UniProt AC: Q63722
• Protein Name: Protein jagged-1
• Gene Name: Jag1
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 1219
• Subcellular Localization: Membrane; Single-pass type I membrane protein.
• Protein Description: Ligand for multiple Notch receptors and involved in the mediation of Notch signaling. May be involved in cell-fate decisions during hematopoiesis. Enhances fibroblast growth factor-induced angiogenesis (in vitro). Seems to be involved in early and late stages of mammalian cardiovascular development. Inhibits myoblast differentiation. May regulate fibroblast growth factor-induced angiogenesis..
• Protein Sequence: MRSPRTRGRPGRPLSLLLALLCALRAKVCGASGQFELEILSMQNVNGELQNGNCCGGARNPGDRKCTRDECDTYFKVCLKEYQSRVTAGGPCSFGSGSTPVIGGNTFNLKASRGNDRNRIVLPFSFAWPRSYTLLVEAWDSSNDTIQPDSIIEKASHSGMINPSRQWQTLKQNTGIAHFEYQIRVTCDDHYYGFGCNKFCRPRDDFFGHYACDQNGNKTCMEGWMGPECNKAICRQGCSPKHGSCKLPGDCRCQYGWQGLYCDKCIPHPGCVHGTCNEPWQCLCETNWGGQLCDKDLNYCGTHQPCLNRGTCSNTGPDKYQCSCPEGYSGPNCEIAEHACLSDPCHNRGSCKETSSGFECECSPGWTGPTCSTNIDDCSPNNCSHGGTCQDLVNGFKCVCPPQWTGKTCQLDANECEAKPCVNARSCKNLIASYYCDCLPGWMGQNCDININDCLGQCQNDASCRDLVNGYRCICPPGYAGDHCERDIDECASNPCLNGGHCQNEINRFQCLCPTGFSGNLCQLDIDYCEPNPCQNGAQCYNRASDYFCKCPEDYEGKNCSHLKDHCRTTPCEVIDSCTVAMASNDTPEGVRYISSNVCGPHGKCKSESGGKFTCDCNKGFTGTYCHENINDCEGNPCTNGGTCIDGVNSYKCICSDGWEGAHCENNINDCSQNPCHYGGTCRDLVNDFYCDCKNGWKGKTCHSRDSQCDEATCNNGGTCYDEVDTFKCMCPGGWEGTTCNIARNSSCLPNPCHNGGTCVVNGDSFTCVCKEGWEGPICTQNTNDCSPHPCYNSGTCVDGDNWYRCECAPGFAGPDCRININECQSSPCAFGATCVDEINGYQCICPPGHSGAKCHEVSGRSCITMGRVILDGAKWDDDCNTCQCLNGRVACSKVWCGPRPCRLHKGHGECPNGQSCIPVLDDQCFVRPCTGAGECRSSSLQPVKTKCTSDSYYQDNCANITFTFNKEMMSPGLTTEHICSELRNLNILKNVSAEYSIYIACEPSLSANNEIHVAISAEDIRDDGNPVKEITDKIIDLVSKRDGNSSLIAAVAEVRVQRRPLKNRTDFLVPLLSSVLTVAWVCCLVTAFYWCVRKRRRKPSSHTHSAPEDNTTNNVREQLNQIKNPIEKHGANTVPIKDYENKNSKMSKIRTHNSEVEEDDMDKHQQKVRFAKQPVYTLVDREEKVPQRTPTKHPNWTNKQDNRDLESAQSLNRMEYIV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
143	N-linked_Glycosylation	VEAWDSSNDTIQPDS EEEECCCCCCCCCCH	55.16	-
217	N-linked_Glycosylation	YACDQNGNKTCMEGW EEECCCCCCCCCCCC	43.97	-
382	N-linked_Glycosylation	IDDCSPNNCSHGGTC CHHCCCCCCCCCCCH	31.86	-
559	N-linked_Glycosylation	PEDYEGKNCSHLKDH CCCCCCCCCHHHCHH	43.30	-
745	N-linked_Glycosylation	TTCNIARNSSCLPNP CCEEECCCCCCCCCC	29.29	-
960	N-linked_Glycosylation	YYQDNCANITFTFNK HHCCCCEEEEEEECH	35.71	-
991	N-linked_Glycosylation	RNLNILKNVSAEYSI HCCCHHCCCCEEEEE	29.54	-
1045	N-linked_Glycosylation	LVSKRDGNSSLIAAV HHHCCCCCCHHHEEE	32.49	-
1064	N-linked_Glycosylation	VQRRPLKNRTDFLVP CCCCCCCCCCCCHHH	60.82	-
1208	Phosphorylation	QDNRDLESAQSLNRM CCCCCHHHHHHHHCH	38.62	27097102
1211	Phosphorylation	RDLESAQSLNRMEYI CCHHHHHHHHCHHHC	27.59	27097102

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of JAG1_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of JAG1_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of JAG1_RAT !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
APBB1_HUMAN	APBB1	physical	26276215

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.