NEK1_MOUSE - dbPTM
NEK1_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID NEK1_MOUSE
UniProt AC P51954
Protein Name Serine/threonine-protein kinase Nek1
Gene Name Nek1
Organism Mus musculus (Mouse).
Sequence Length 1203
Subcellular Localization Nucleus . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Associated with the pericentriolar material (By similarity). Localizes to centrosome during interphase and mitosis (PubMed:16267153).
Protein Description Phosphorylates serines and threonines, but also appears to possess tyrosine kinase activity. [PubMed: 1382974 Involved in DNA damage checkpoint control and for proper DNA damage repair]
Protein Sequence MEKYVRLQKIGEGSFGKAVLVKSTEDGRHYVIKEINISRMSDKERQESRREVAVLANMKHPNIVQYKESFEENGSLYIVMDYCEGGDLFKRINAQKGALFQEDQILDWFVQICLALKHVHDRKILHRDIKSQNIFLTKDGTVQLGDFGIARVLNSTVELARTCIGTPYYLSPEICENKPYNNKSDIWALGCVLYELCTLKHAFEAGNMKNLVLKIISGSFPPVSPHYSYDLRSLLSQLFKRNPRDRPSVNSILEKGFIAKRIEKFLSPQLIAEEFCLKTLSKFGPQPLPGKRPASGQGVSSFVPAQKITKPAAKYGVPLTYKKYGDKKLLEKKPPPKHKQAHQIPVKKMNSGEERKKMSEEAAKKRRLEFIEKEKKQKDQIRFLKAEQMKRQEKQRLERINRAREQGWRNVLRAGGSGEVKASFFGIGGAVSPSPCSPRGQYEHYHAIFDQMQRLRAEDNEARWKGGIYGRWLPERQKGHLAVERANQVEEFLQRKREAMQNKARAEGHVVYLARLRQIRLQNFNERQQIKAKLRGENKEADGTKGQEATEETDMRLKKMESLKAQTNARAAVLKEQLERKRKEAYEREKKVWEEHLVARVKSSDVPLPLELLETGGSPSKQQVKPVISVTSALKEVGLDGSLTDTQEEEMEKSNSAISSKREILRRLNENLKAQEDEKEKQHHSGSCETVGHKDEREYETENAISSDRKKWEMGGQLVIPLDAVTLDTSFSATEKHTVGEVIKLDSNGSPRKVWGKNPTDSVLKILGEAELQLQTELLENTSFKSEVYAEEENYKPLLTEEENLQCISKEINPSATVDSTETKSPKFTEVSPQMSEGNVEEPDDLETEVLQEPSSTHTDGSLPPVLNDVWTREKEAAKETELEDKVAVQQSEVCEDRIPGNVDQSCKDQRDPAVDDSPQSGCDVEKSVQPESIFQKVVHSKDLNLVQAVHCSPEEPIPIRSHSDSPPKTKSKNSLLIGLSTGLFDANNPKMLRTCSLPDLSKLFRTLMDVPTVGDVHQDSLEIDELEDEPIKEGPSDSEDTVFEETDTDLQELQASMEQLLREQPGDEYSEEEESVLKSSDVEQTARGTDAPDEEDNPSSESALNEEWHSDNSDAETTSECEYDSVFNHLEELRLHLEQEMGFEKFFEVYEKVKAIHEDEDENIEICSTIVENILGNEHQHLYAKILHLVMADGAYQEDNDE
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
14PhosphorylationLQKIGEGSFGKAVLV
CEECCCCCCCEEEEE		26.9024719451
156PhosphorylationIARVLNSTVELARTC
HHHHHHHHHHHHHHH		19.5429514104
162PhosphorylationSTVELARTCIGTPYY
HHHHHHHHHCCCCCC		11.67-
295PhosphorylationLPGKRPASGQGVSSF
CCCCCCCCCCCCCCC		34.0425338131
315PhosphorylationITKPAAKYGVPLTYK
CCCCHHHHCCCCEEH		20.7329514104
417PhosphorylationNVLRAGGSGEVKASF
HHHHCCCCCCCEEEE		30.75-
423PhosphorylationGSGEVKASFFGIGGA
CCCCCEEEEEECCCE		18.5229514104
432PhosphorylationFGIGGAVSPSPCSPR
EECCCEECCCCCCCC		21.0829233185
434PhosphorylationIGGAVSPSPCSPRGQ
CCCEECCCCCCCCCC		30.9125266776
437PhosphorylationAVSPSPCSPRGQYEH
EECCCCCCCCCCHHH		22.4823684622
442PhosphorylationPCSPRGQYEHYHAIF
CCCCCCCHHHHHHHH		13.9029514104
603PhosphorylationHLVARVKSSDVPLPL
HHHHHHHCCCCCCCH		28.9924925903
604PhosphorylationLVARVKSSDVPLPLE
HHHHHHCCCCCCCHH		36.5924925903
615PhosphorylationLPLELLETGGSPSKQ
CCHHHHHCCCCCCHH		46.9726239621
618PhosphorylationELLETGGSPSKQQVK
HHHHCCCCCCHHCCC		27.6124925903
620PhosphorylationLETGGSPSKQQVKPV
HHCCCCCCHHCCCCE		44.8121149613
642PhosphorylationKEVGLDGSLTDTQEE
HHHCCCCCCCCCHHH		27.9730635358
644PhosphorylationVGLDGSLTDTQEEEM
HCCCCCCCCCHHHHH		38.4030635358
646PhosphorylationLDGSLTDTQEEEMEK
CCCCCCCCHHHHHHH		32.4230635358
747PhosphorylationGEVIKLDSNGSPRKV
CEEEEECCCCCCCCC		54.2329550500
750PhosphorylationIKLDSNGSPRKVWGK
EEECCCCCCCCCCCC		26.2829550500
786PhosphorylationLENTSFKSEVYAEEE
HHCCCCCCCCCCCCC		30.22-
815PhosphorylationISKEINPSATVDSTE
HHCCCCCCCCCCCCC		31.8925619855
817PhosphorylationKEINPSATVDSTETK
CCCCCCCCCCCCCCC		29.2325619855
820PhosphorylationNPSATVDSTETKSPK
CCCCCCCCCCCCCCC		24.6528066266
821PhosphorylationPSATVDSTETKSPKF
CCCCCCCCCCCCCCC		43.1228066266
823PhosphorylationATVDSTETKSPKFTE
CCCCCCCCCCCCCCC		36.5925619855
825PhosphorylationVDSTETKSPKFTEVS
CCCCCCCCCCCCCCC		40.5226824392
832PhosphorylationSPKFTEVSPQMSEGN
CCCCCCCCCCCCCCC		11.81-
918PhosphorylationRDPAVDDSPQSGCDV
CCCCCCCCCCCCCCC		22.0023684622
921PhosphorylationAVDDSPQSGCDVEKS
CCCCCCCCCCCCHHC		44.7823684622
953PhosphorylationLVQAVHCSPEEPIPI
EEEEEECCCCCCCCC		22.0725521595
962PhosphorylationEEPIPIRSHSDSPPK
CCCCCCCCCCCCCCC		28.2326643407
964PhosphorylationPIPIRSHSDSPPKTK
CCCCCCCCCCCCCCC		40.8226643407
966PhosphorylationPIRSHSDSPPKTKSK
CCCCCCCCCCCCCCC		46.2325266776
972PhosphorylationDSPPKTKSKNSLLIG
CCCCCCCCCCCEEEE		42.1529899451
995PhosphorylationNNPKMLRTCSLPDLS
CCHHHHCCCCHHHHH		11.5025619855
997PhosphorylationPKMLRTCSLPDLSKL
HHHHCCCCHHHHHHH		42.1825521595
1002PhosphorylationTCSLPDLSKLFRTLM
CCCHHHHHHHHHHHC		34.3925619855
1021PhosphorylationVGDVHQDSLEIDELE
CCCCCCCCCCHHCCC		22.7227180971
1037PhosphorylationEPIKEGPSDSEDTVF
CCCCCCCCCCCCCCC		65.7030352176
1070PhosphorylationREQPGDEYSEEEESV
HHCCCCCCCHHHHHH		26.5625619855
1071PhosphorylationEQPGDEYSEEEESVL
HCCCCCCCHHHHHHH		36.1625521595
1076PhosphorylationEYSEEEESVLKSSDV
CCCHHHHHHHCCCCH		35.7125619855
1080PhosphorylationEEESVLKSSDVEQTA
HHHHHHCCCCHHHHH		27.8425293948
1081PhosphorylationEESVLKSSDVEQTAR
HHHHHCCCCHHHHHC		44.0525293948
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of NEK1_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of NEK1_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of NEK1_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
WWTR1_MOUSEWwtr1physical
21474562
CU002_HUMANC21orf2physical
26496610
BRAP_HUMANBRAPphysical
26496610
DPM3_HUMANDPM3physical
26496610
TOP1M_HUMANTOP1MTphysical
26496610
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of NEK1_MOUSE

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Protein phosphorylation and expression profiling by Yin-yangmultidimensional liquid chromatography (Yin-yang MDLC) massspectrometry.";
Dai J., Jin W.-H., Sheng Q.-H., Shieh C.-H., Wu J.-R., Zeng R.;
J. Proteome Res. 6:250-262(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1071, AND MASSSPECTROMETRY.
"Phosphoproteomic analysis of the developing mouse brain.";
Ballif B.A., Villen J., Beausoleil S.A., Schwartz D., Gygi S.P.;
Mol. Cell. Proteomics 3:1093-1101(2004).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-618, AND MASSSPECTROMETRY.

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