NBPF3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NBPF3_HUMAN
• UniProt AC: Q9H094
• Protein Name: Neuroblastoma breakpoint family member 3
• Gene Name: NBPF3
• Organism: Homo sapiens (Human).
• Sequence Length: 633
• Subcellular Localization: Cytoplasm .
• Protein Sequence: MPLTPTVQGFQWTLRGPDVETSPFGAPRAASHGVGRHQELRDPTVPGPTSSATNVSMVVSAGPWSGEKAEMNILEINKKSRPQLAENKQQFRNLKQKCLVTQVAYFLANRQNNYDYEDCKDLIKSMLRDERLLTEEKLAEELGQAEELRQYKVLVHSQERELTQLREKLQEGRDASRSLNQHLQALLTPDEPDNSQGRDLREQLAEGCRLAQHLVQKLSPENDDDEDEDVKVEEAEKVQELYAPREVQKAEEKEVPEDSLEECAITCSNSHHPCESNQPYGNTRITFEEDQVDSTLIDSSSHDEWLDAVCIIPENESDHEQEEEKGPVSPRNLQESEEEEAPQESWDEGDWTLSIPPDMSASYQSDRSTFHSVEEQQVGLALDIGRHWCDQVKKEDQEATSPRLSRELLDEKEPEVLQDSLDRFYSTPFEYLELPDLCQPYRSDFYSLQEQHLGLALDLDRMKKDQEEEEDQGPPCPRLSRELPEVVEPEDLQDSLDRWYSTPFSYPELPDSCQPYGSCFYSLEEEHVGFSLDVDEIEKYQEGEEDQKPPCPRLNEVLMEAEEPEVLQDSLDRCYSTTSTYFQLHASFQQYRSAFYSFEEQDVSLALDVDNRFFTLTVIRHHLAFQMGVIFPH

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
13	Phosphorylation	TVQGFQWTLRGPDVE CCCCEEEEECCCCCC	8.87	24043423
67 (in isoform 4)	Ubiquitination	-	43.51	21906983
67	Ubiquitination	SAGPWSGEKAEMNIL ECCCCCCCHHHEEEE	43.51	22817900
81	Ubiquitination	LEINKKSRPQLAENK EEECCCCCHHHHHHH	31.68	22817900
81 (in isoform 2)	Ubiquitination	-	31.68	21906983
137	Ubiquitination	ERLLTEEKLAEELGQ HHHCCHHHHHHHHCC	46.92	22817900
137 (in isoform 3)	Ubiquitination	-	46.92	21906983
137 (in isoform 1)	Ubiquitination	-	46.92	21906983
152	Ubiquitination	AEELRQYKVLVHSQE HHHHHHHHHHHCHHH	22.28	-
342 (in isoform 4)	Ubiquitination	-	41.57	21906983
356 (in isoform 2)	Ubiquitination	-	18.57	21906983
400 (in isoform 3)	Ubiquitination	-	38.21	21906983
412	Ubiquitination	SRELLDEKEPEVLQD HHHHHCCCCCHHHHH	77.55	-
412 (in isoform 1)	Ubiquitination	-	77.55	21906983
420	Phosphorylation	EPEVLQDSLDRFYST CCHHHHHHHHHHHCC	21.14	23186163
570	Phosphorylation	EPEVLQDSLDRCYST CHHHHHHHHHHHHHC	21.14	-
593	Phosphorylation	ASFQQYRSAFYSFEE HHHHHHHHCHHCCCC	20.14	25850435
596	Phosphorylation	QQYRSAFYSFEEQDV HHHHHCHHCCCCCCE	16.50	25850435
597	Phosphorylation	QYRSAFYSFEEQDVS HHHHCHHCCCCCCEE	21.52	25850435

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NBPF3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NBPF3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NBPF3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SEN15_HUMAN	TSEN15	physical	16189514
A4_HUMAN	APP	physical	21832049
NBPF3_HUMAN	NBPF3	physical	25416956
NBPF1_HUMAN	NBPF1	physical	26186194
NBPF1_HUMAN	NBPF1	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.