dbPTM

MED21_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	MED21_MOUSE
UniProt AC	Q9CQ39
Protein Name	Mediator of RNA polymerase II transcription subunit 21
Gene Name	Med21
Organism	Mus musculus (Mouse).
Sequence Length	144
Subcellular Localization	Nucleus .
Protein Description	Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity)..
Protein Sequence	MADRLTQLQDAVNSLADQFCNAIGVLQQCGPPASFSNIQTAINKDQPANPTEEYAQLFAALIARTAKDIDVLIDSLPSEESTAALQAASLYKLEEENHEAATCLEDVVYRGDMLLEKIQSALADIAQSQLKTRSVTHSHSLPDS

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
131	Ubiquitination	DIAQSQLKTRSVTHS HHHHHHHHHCCCCCC	33.97	-
140	Phosphorylation	RSVTHSHSLPDS--- CCCCCCCCCCCC---	44.61	27841257
144	Phosphorylation	HSHSLPDS------- CCCCCCCC-------	39.93	30635358

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of MED21_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of MED21_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of MED21_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PK3CA_MOUSE	Pik3ca	physical	9671713
BRD2_MOUSE	Brd2	physical	9671713
MCRS1_MOUSE	Mcrs1	physical	9671713
MED7_MOUSE	Med7	physical	9671713
AAGAB_MOUSE	Aagab	physical	9671713
TNFC_MOUSE	Ltb	physical	9671713
MED6_MOUSE	Med6	physical	9671713

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of MED21_MOUSE

Related Literatures of Post-Translational Modification