TNFC_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TNFC_MOUSE
• UniProt AC: P41155
• Protein Name: Lymphotoxin-beta
• Gene Name: Ltb
• Organism: Mus musculus (Mouse).
• Sequence Length: 306
• Subcellular Localization: Membrane ; Single-pass type II membrane protein .
• Protein Description: Cytokine that binds to LTBR/TNFRSF3. May play a specific role in immune response regulation. Provides the membrane anchor for the attachment of the heterotrimeric complex to the cell surface..
• Protein Sequence: MGTRGLQGLGGRPQGRGCLLLAVAGATSLVTLLLAVPITVLAVLALVPQDQGRRVEKIIGSGAQAQKRLDDSKPSCILPSPSSLSETPDPRLHPQRSNASRNLASTSQGPVAQSSREASAWMTILSPAADSTPDPGVQQLPKGEPETDLNPELPAAHLIGAWMSGQGLSWEASQEEAFLRSGAQFSPTHGLALPQDGVYYLYCHVGYRGRTPPAGRSRARSLTLRSALYRAGGAYGRGSPELLLEGAETVTPVVDPIGYGSLWYTSVGFGGLAQLRSGERVYVNISHPDMVDYRRGKTFFGAVMVG

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
27	Phosphorylation	LLAVAGATSLVTLLL HHHHHCHHHHHHHHH	22.98	-
31	Phosphorylation	AGATSLVTLLLAVPI HCHHHHHHHHHHHHH	19.58	-
98	N-linked_Glycosylation	RLHPQRSNASRNLAS CCCCCCCCHHHHHCC	44.09	-
284	N-linked_Glycosylation	SGERVYVNISHPDMV CCCEEEEECCCCCCC	16.62	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TNFC_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TNFC_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TNFC_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of TNFC_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.