BRD2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: BRD2_MOUSE
• UniProt AC: Q7JJ13
• Protein Name: Bromodomain-containing protein 2
• Gene Name: Brd2
• Organism: Mus musculus (Mouse).
• Sequence Length: 798
• Subcellular Localization: Nucleus . Detected on chromatin and nucleosomes..
• Protein Description: Binds hyperacetylated chromatin and plays a role in the regulation of transcription, probably by chromatin remodeling. Regulates transcription of the CCND1 gene. Plays a role in nucleosome assembly (By similarity). May play a role in spermatogenesis or folliculogenesis..
• Protein Sequence: MLQNVTPHKLPGEGNAGLLGLGPEAAAPGKRIRKPSLLYEGFESPTMASVPALQLAPANPPPPEVSNPKKPGRVTNQLQYLHKVVMKALWKHQFAWPFRQPVDAVKLGLPDYHKIIKQPMDMGTIKRRLENNYYWAASECMQDFNTMFTNCYIYNKPTDDIVLMAQTLEKIFLQKVASMPQEEQELVVTIPKNSHKKGAKLAALQGSITSAHQVPAVSSVSHTALYTPPPEIPTTVLNIPHPSVISSPLLKSLHSAGPPLLAVSAAPPAQPLAKKKGVKRKADTTTPTPTAILAPGSPASPPGSLEPKAARLPPMRRESGRPIKPPRKDLPDSQQQHQSSKKGKLSEQLKHCNGILKELLSKKHAAYAWPFYKPVDASALGLHDYHDIIKHPMDLSTVKRKMENRDYRDAQEFAADVRLMFSNCYKYNPPDHDVVAMARKLQDVFEFRYAKMPDEPLEPGPLPVSTALPPGLTKSSSESSSEESSSESSSEEEEEEEEDEDEEESESSDSEEERAHRLAELQEQLRAVHEQLAALSQGPISKPKRKREKKEKKKKRKAEKHRGRIGIDEDDKGPRAPRPPQPKKSKKAGGGGSNATTLSHPGFGTSGGSSNKLPKKSQKTAPPVLPTGYDSEEEEESRPMSYDEKRQLSLDINKLPGEKLGRVVHIIQAREPSLRDSNPEEIEIDFETLKPSTLRELERYVLSCLRKKPRKPYTIRKPVGKTKEELALEKKRELEKRLQDVSGQLNSTKKPPKKASEKTESSAQQVAVSRLSASSSSSDSSSSSSSSSSSDTSDSDSG

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MLQNVTPH -------CCCCCCCC	8.62	-
6	Phosphorylation	--MLQNVTPHKLPGE --CCCCCCCCCCCCC	27.50	26239621
9	Acetylation	LQNVTPHKLPGEGNA CCCCCCCCCCCCCCC	58.54	88611
30	Acetylation	PEAAAPGKRIRKPSL HHHCCCCCCCCCHHH	43.52	88615
36	Phosphorylation	GKRIRKPSLLYEGFE CCCCCCHHHHCCCCC	33.76	26160508
39	Phosphorylation	IRKPSLLYEGFESPT CCCHHHHCCCCCCCC	21.21	26160508
44	Phosphorylation	LLYEGFESPTMASVP HHCCCCCCCCCCCCC	24.33	26160508
46	Phosphorylation	YEGFESPTMASVPAL CCCCCCCCCCCCCHH	34.35	25266776
49	Phosphorylation	FESPTMASVPALQLA CCCCCCCCCCHHHCC	20.15	26160508
112	Phosphorylation	VKLGLPDYHKIIKQP HHCCCCCHHHHHCCC	11.76	-
124	Phosphorylation	KQPMDMGTIKRRLEN CCCCCHHHHHHHHHH	19.38	-
133	Phosphorylation	KRRLENNYYWAASEC HHHHHHCCEEEHHHH	16.38	22802335
134	Phosphorylation	RRLENNYYWAASECM HHHHHCCEEEHHHHH	7.24	22802335
138	Phosphorylation	NNYYWAASECMQDFN HCCEEEHHHHHHHHH	24.47	22802335
158	Phosphorylation	CYIYNKPTDDIVLMA EEECCCCCCHHHHHH	48.16	22802335
167	Phosphorylation	DIVLMAQTLEKIFLQ HHHHHHHHHHHHHHH	27.61	22802335
284	Phosphorylation	GVKRKADTTTPTPTA CCCCCCCCCCCCCCE	37.11	25619855
285	Phosphorylation	VKRKADTTTPTPTAI CCCCCCCCCCCCCEE	31.18	25619855
286	Phosphorylation	KRKADTTTPTPTAIL CCCCCCCCCCCCEEE	27.53	25619855
288	Phosphorylation	KADTTTPTPTAILAP CCCCCCCCCCEEECC	31.05	25619855
290	Phosphorylation	DTTTPTPTAILAPGS CCCCCCCCEEECCCC	28.89	25619855
297	Phosphorylation	TAILAPGSPASPPGS CEEECCCCCCCCCCC	19.08	27087446
300	Phosphorylation	LAPGSPASPPGSLEP ECCCCCCCCCCCCCC	34.70	27087446
304	Phosphorylation	SPASPPGSLEPKAAR CCCCCCCCCCCHHHC	35.02	22942356
319	Phosphorylation	LPPMRRESGRPIKPP CCCCCCCCCCCCCCC	37.99	28725479
333	Phosphorylation	PRKDLPDSQQQHQSS CCCCCCHHHHHHHHH	28.13	22817900
339	Phosphorylation	DSQQQHQSSKKGKLS HHHHHHHHHHHHHHH	41.84	22817900
340	Phosphorylation	SQQQHQSSKKGKLSE HHHHHHHHHHHHHHH	31.64	22817900
361	Phosphorylation	GILKELLSKKHAAYA HHHHHHHHHCCHHHC	52.89	22817900
585	Phosphorylation	RPPQPKKSKKAGGGG CCCCCCCCCCCCCCC	45.58	24704852
620	Phosphorylation	LPKKSQKTAPPVLPT CCCCCCCCCCCCCCC	36.44	25619855
627	Phosphorylation	TAPPVLPTGYDSEEE CCCCCCCCCCCCHHH	44.18	25619855
629	Phosphorylation	PPVLPTGYDSEEEEE CCCCCCCCCCHHHHH	20.83	27087446
631	Phosphorylation	VLPTGYDSEEEEESR CCCCCCCCHHHHHHC	38.12	27087446
637	Phosphorylation	DSEEEEESRPMSYDE CCHHHHHHCCCCHHH	44.99	25619855
641	Phosphorylation	EEESRPMSYDEKRQL HHHHCCCCHHHHHHH	31.92	25619855
642	Phosphorylation	EESRPMSYDEKRQLS HHHCCCCHHHHHHHH	23.13	25619855
649	Phosphorylation	YDEKRQLSLDINKLP HHHHHHHHCCHHHCC	18.69	26824392
747	Phosphorylation	DVSGQLNSTKKPPKK HHHHHCCCCCCCCCC	50.63	28066266
748	Phosphorylation	VSGQLNSTKKPPKKA HHHHCCCCCCCCCCC	41.85	28066266
769	Phosphorylation	SAQQVAVSRLSASSS HHHHHHHHHHHCCCC	20.12	28059163
775	Phosphorylation	VSRLSASSSSSDSSS HHHHHCCCCCCCCCC	33.68	-
786	Phosphorylation	DSSSSSSSSSSSDTS CCCCCCCCCCCCCCC	35.87	-
788	Phosphorylation	SSSSSSSSSSDTSDS CCCCCCCCCCCCCCC	35.49	-
789	Phosphorylation	SSSSSSSSSDTSDSD CCCCCCCCCCCCCCC	33.89	-
790	Phosphorylation	SSSSSSSSDTSDSDS CCCCCCCCCCCCCCC	47.02	-
797	Phosphorylation	SDTSDSDSG------ CCCCCCCCC------	50.80	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of BRD2_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of BRD2_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of BRD2_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of BRD2_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Large-scale phosphorylation analysis of mouse liver.";
Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-297 AND SER-300, ANDMASS SPECTROMETRY.
PubMed: 17242355