dbPTM

MCRS1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	MCRS1_MOUSE
UniProt AC	Q99L90
Protein Name	Microspherule protein 1
Gene Name	Mcrs1
Organism	Mus musculus (Mouse).
Sequence Length	462
Subcellular Localization	Nucleus . Nucleus, nucleolus . Cytoplasm . In microspherules in the nucleolus.
Protein Description	Modulates the transcription repressor activity of DAXX by recruiting it to the nucleolus. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. May also be an inhibitor of TERT telomerase activity. Binds to G-quadruplex structures in mRNA. Binds to RNA homopolymer poly(G) and poly(U)..
Protein Sequence	MDKDSQGLLDSSLMASGTASRSEDEESLAGQKRASSQALGTIPKRRSSSRFIKRKKFDDELVESSLAKSSTRVKGAGGVESGRCSGSEPSSSEKKKVSKAPSTPVPPSPAPTPGLTKRVKKSKQPLQVTKDLGRWKPADDLLLINAVLQTNDLTSVHLGVKFSCRFTLREVQERWYALLYDPVISKLACQAMRQLHPEAIAAIQSKALFSKAEEQLLSKVGSSSQPTLETFQDLLHTHPDAFYLARTAKALQAHWQLMKQYYLLEDQTVQPLPKGDQVLNFSDAEDLIDDSKLKDMRDEVLEHELTVADRRQKREIRQLEQELHKWQVLVDSITGMGSPDFDNQTLAVLRGRMVRYLMRSREITLGRATKDNQIDVDLSLEGPAWKISRKQGVIKLKNNGDFFIANEGRRPIYIDGRPVLCGSKWRLSNNSVVEIASLRFVFLINQDLIALIRAEAAKITPQ

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MDKDSQGL -------CCCCCHHC	15.13	-
9	Phosphorylation	DKDSQGLLDSSLMAS CCCCHHCCCHHHHHC	8.41	24719451
11	Phosphorylation	DSQGLLDSSLMASGT CCHHCCCHHHHHCCC	25.91	26643407
12	Phosphorylation	SQGLLDSSLMASGTA CHHCCCHHHHHCCCC	23.10	26643407
16	Phosphorylation	LDSSLMASGTASRSE CCHHHHHCCCCCCCC	23.78	23429704
18	Phosphorylation	SSLMASGTASRSEDE HHHHHCCCCCCCCCH	20.97	26643407
20	Phosphorylation	LMASGTASRSEDEES HHHCCCCCCCCCHHH	35.86	23429704
22	Phosphorylation	ASGTASRSEDEESLA HCCCCCCCCCHHHHH	47.07	28973931
27	Phosphorylation	SRSEDEESLAGQKRA CCCCCHHHHHHHHHH	22.82	26643407
32	Acetylation	EESLAGQKRASSQAL HHHHHHHHHHHHHHH	49.35	7676593
35	Phosphorylation	LAGQKRASSQALGTI HHHHHHHHHHHHCCC	27.32	28066266
36	Phosphorylation	AGQKRASSQALGTIP HHHHHHHHHHHCCCC	20.63	28066266
41	Phosphorylation	ASSQALGTIPKRRSS HHHHHHCCCCCCCCC	34.65	29899451
64	Phosphorylation	FDDELVESSLAKSST CCHHHHHHHHHCCCC	24.15	22418434
70	Phosphorylation	ESSLAKSSTRVKGAG HHHHHCCCCCCCCCC	21.37	22418434
71	Phosphorylation	SSLAKSSTRVKGAGG HHHHCCCCCCCCCCC	46.72	22418434
81	Phosphorylation	KGAGGVESGRCSGSE CCCCCCCCCCCCCCC	29.18	30635358
85	Phosphorylation	GVESGRCSGSEPSSS CCCCCCCCCCCCCHH	43.95	25266776
87	Phosphorylation	ESGRCSGSEPSSSEK CCCCCCCCCCCHHHC	30.00	25266776
90	Phosphorylation	RCSGSEPSSSEKKKV CCCCCCCCHHHCCCC	42.31	30635358
91	Phosphorylation	CSGSEPSSSEKKKVS CCCCCCCHHHCCCCC	53.91	30635358
92	Phosphorylation	SGSEPSSSEKKKVSK CCCCCCHHHCCCCCC	58.74	30635358
102	Phosphorylation	KKVSKAPSTPVPPSP CCCCCCCCCCCCCCC	50.64	21082442
103	Phosphorylation	KVSKAPSTPVPPSPA CCCCCCCCCCCCCCC	27.52	26824392
108	Phosphorylation	PSTPVPPSPAPTPGL CCCCCCCCCCCCCCC	27.85	21082442
112	Phosphorylation	VPPSPAPTPGLTKRV CCCCCCCCCCCCCCH	31.90	25266776
116	Phosphorylation	PAPTPGLTKRVKKSK CCCCCCCCCCHHCCC	23.79	29176673
123	Acetylation	TKRVKKSKQPLQVTK CCCHHCCCCCCEEEC	65.89	23806337
130	Acetylation	KQPLQVTKDLGRWKP CCCCEEECCCCCCCC	52.69	23806337
268	Phosphorylation	YYLLEDQTVQPLPKG HHCCCCCEECCCCCC	33.17	23984901
282	Phosphorylation	GDQVLNFSDAEDLID CCEEECCCCHHHHCC	34.53	27087446
291	Phosphorylation	AEDLIDDSKLKDMRD HHHHCCHHHHHHHHH	35.82	25619855

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of MCRS1_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of MCRS1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of MCRS1_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of MCRS1_MOUSE !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of MCRS1_MOUSE

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"The phagosomal proteome in interferon-gamma-activated macrophages."; Trost M., English L., Lemieux S., Courcelles M., Desjardins M.,Thibault P.; Immunity 30:143-154(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-282, AND MASSSPECTROMETRY.	19144319 [Abstract]
"Protein phosphorylation and expression profiling by Yin-yangmultidimensional liquid chromatography (Yin-yang MDLC) massspectrometry."; Dai J., Jin W.-H., Sheng Q.-H., Shieh C.-H., Wu J.-R., Zeng R.; J. Proteome Res. 6:250-262(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-282, AND MASSSPECTROMETRY.	17203969 [Abstract]
"Phosphoproteomic analysis of the developing mouse brain."; Ballif B.A., Villen J., Beausoleil S.A., Schwartz D., Gygi S.P.; Mol. Cell. Proteomics 3:1093-1101(2004). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-282, AND MASSSPECTROMETRY.	15345747 [Abstract]