MAGC1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MAGC1_HUMAN
• UniProt AC: O60732
• Protein Name: Melanoma-associated antigen C1
• Gene Name: MAGEC1
• Organism: Homo sapiens (Human).
• Sequence Length: 1142
• Protein Sequence: MGDKDMPTAGMPSLLQSSSESPQSCPEGEDSQSPLQIPQSSPESDDTLYPLQSPQSRSEGEDSSDPLQRPPEGKDSQSPLQIPQSSPEGDDTQSPLQNSQSSPEGKDSLSPLEISQSPPEGEDVQSPLQNPASSFFSSALLSIFQSSPESTQSPFEGFPQSVLQIPVSAASSSTLVSIFQSSPESTQSPFEGFPQSPLQIPVSRSFSSTLLSIFQSSPERTQSTFEGFAQSPLQIPVSPSSSSTLLSLFQSFSERTQSTFEGFAQSSLQIPVSPSFSSTLVSLFQSSPERTQSTFEGFPQSPLQIPVSSSSSSTLLSLFQSSPERTHSTFEGFPQSLLQIPMTSSFSSTLLSIFQSSPESAQSTFEGFPQSPLQIPGSPSFSSTLLSLFQSSPERTHSTFEGFPQSPLQIPMTSSFSSTLLSILQSSPESAQSAFEGFPQSPLQIPVSSSFSYTLLSLFQSSPERTHSTFEGFPQSPLQIPVSSSSSSSTLLSLFQSSPECTQSTFEGFPQSPLQIPQSPPEGENTHSPLQIVPSLPEWEDSLSPHYFPQSPPQGEDSLSPHYFPQSPPQGEDSLSPHYFPQSPQGEDSLSPHYFPQSPPQGEDSMSPLYFPQSPLQGEEFQSSLQSPVSICSSSTPSSLPQSFPESSQSPPEGPVQSPLHSPQSPPEGMHSQSPLQSPESAPEGEDSLSPLQIPQSPLEGEDSLSSLHFPQSPPEWEDSLSPLHFPQFPPQGEDFQSSLQSPVSICSSSTSLSLPQSFPESPQSPPEGPAQSPLQRPVSSFFSYTLASLLQSSHESPQSPPEGPAQSPLQSPVSSFPSSTSSSLSQSSPVSSFPSSTSSSLSKSSPESPLQSPVISFSSSTSLSPFSEESSSPVDEYTSSSDTLLESDSLTDSESLIESEPLFTYTLDEKVDELARFLLLKYQVKQPITKAEMLTNVISRYTGYFPVIFRKAREFIEILFGISLREVDPDDSYVFVNTLDLTSEGCLSDEQGMSQNRLLILILSIIFIKGTYASEEVIWDVLSGIGVRAGREHFAFGEPRELLTKVWVQEHYLEYREVPNSSPPRYEFLWGPRAHSEVIKRKVVEFLAMLKNTVPITFPSSYKDALKDVEERAQAIIDTTDDSTATESASSSVMSPSFSSE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
58	Phosphorylation	LQSPQSRSEGEDSSD CCCCCCCCCCCCCCC	56.02	29523821
63	Phosphorylation	SRSEGEDSSDPLQRP CCCCCCCCCCCCCCC	32.13	23917254
64	Phosphorylation	RSEGEDSSDPLQRPP CCCCCCCCCCCCCCC	56.41	29523821
76	Phosphorylation	RPPEGKDSQSPLQIP CCCCCCCCCCCCCCC	35.72	23186163
78	Phosphorylation	PEGKDSQSPLQIPQS CCCCCCCCCCCCCCC	31.37	23917254
85	Phosphorylation	SPLQIPQSSPEGDDT CCCCCCCCCCCCCCC	42.37	25262027
86	Phosphorylation	PLQIPQSSPEGDDTQ CCCCCCCCCCCCCCC	23.02	23917254
92	Phosphorylation	SSPEGDDTQSPLQNS CCCCCCCCCCCCCCC	35.37	23917254
94	Phosphorylation	PEGDDTQSPLQNSQS CCCCCCCCCCCCCCC	29.66	25262027
99	Phosphorylation	TQSPLQNSQSSPEGK CCCCCCCCCCCCCCC	20.62	25262027
101	Phosphorylation	SPLQNSQSSPEGKDS CCCCCCCCCCCCCCC	47.91	25262027
102	Phosphorylation	PLQNSQSSPEGKDSL CCCCCCCCCCCCCCC	21.23	23917254
113	Ubiquitination	KDSLSPLEISQSPPE CCCCCCCCCCCCCCC	43.93	-
205	Phosphorylation	LQIPVSRSFSSTLLS CCCCCCCCHHHHHHH	23.21	26434776
207	Phosphorylation	IPVSRSFSSTLLSIF CCCCCCHHHHHHHHH	24.53	26434776
208	Phosphorylation	PVSRSFSSTLLSIFQ CCCCCHHHHHHHHHH	22.51	30087585
209	Phosphorylation	VSRSFSSTLLSIFQS CCCCHHHHHHHHHHC	30.44	24043423
212	Phosphorylation	SFSSTLLSIFQSSPE CHHHHHHHHHHCCCC	25.19	23186163
216	Phosphorylation	TLLSIFQSSPERTQS HHHHHHHCCCCHHHH	36.79	29523821
217	Phosphorylation	LLSIFQSSPERTQST HHHHHHCCCCHHHHC	21.72	29507054
278	Phosphorylation	PVSPSFSSTLVSLFQ CCCCCHHHHHHHHHH	24.61	30087585
279	Phosphorylation	VSPSFSSTLVSLFQS CCCCHHHHHHHHHHC	29.95	30087585
301	Phosphorylation	TFEGFPQSPLQIPVS CCCCCCCCCCCCCCC	28.02	28655764
309	Phosphorylation	PLQIPVSSSSSSTLL CCCCCCCCCCHHHHH	34.18	-
322	Phosphorylation	LLSLFQSSPERTHST HHHHHHCCCCCCCCC	21.72	-
345	Phosphorylation	LQIPMTSSFSSTLLS HCCCCCCCHHHHHHH	21.71	-
380	Phosphorylation	LQIPGSPSFSSTLLS CCCCCCCCHHHHHHH	39.18	30087585
382	Phosphorylation	IPGSPSFSSTLLSLF CCCCCCHHHHHHHHH	27.10	23186163
392	Phosphorylation	LLSLFQSSPERTHST HHHHHHCCCCCCCCC	21.72	-
415	Phosphorylation	LQIPMTSSFSSTLLS CCCCCCCCHHHHHHH	21.71	-
462	Phosphorylation	LLSLFQSSPERTHST HHHHHCCCCCCCCCC	21.72	-
476	Phosphorylation	TFEGFPQSPLQIPVS CCCCCCCCCCCCCCC	28.02	-
911	Ubiquitination	FTYTLDEKVDELARF EEEECCHHHHHHHHH	55.44	-
922	Ubiquitination	LARFLLLKYQVKQPI HHHHHHHHHHHCCCC	33.34	23000965
926	Ubiquitination	LLLKYQVKQPITKAE HHHHHHHCCCCCHHH	34.53	23000965
931	Ubiquitination	QVKQPITKAEMLTNV HHCCCCCHHHHHHHH	42.97	23000965
936	Phosphorylation	ITKAEMLTNVISRYT CCHHHHHHHHHHHHH	26.57	25332170
1046	Ubiquitination	EPRELLTKVWVQEHY CHHHHHHHHHHHHHH	33.78	22817900
1062	Phosphorylation	EYREVPNSSPPRYEF HHCCCCCCCCCCEEE	37.85	29507054
1063	Phosphorylation	YREVPNSSPPRYEFL HCCCCCCCCCCEEEC	45.63	9618514
1083	Ubiquitination	HSEVIKRKVVEFLAM CHHHHHHHHHHHHHH	45.70	-
1092	Ubiquitination	VEFLAMLKNTVPITF HHHHHHHCCCCCCCC	37.17	-
1108	Ubiquitination	SSYKDALKDVEERAQ HHHHHHHHHHHHHHH	62.54	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MAGC1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MAGC1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MAGC1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CTG1B_HUMAN	CTAG1B	physical	17137291
T2FA_HUMAN	GTF2F1	physical	17137291
H2AZ_HUMAN	H2AFZ	physical	17137291
ROCK2_HUMAN	ROCK2	physical	17137291
ATP5L_HUMAN	ATP5L	physical	17137291
RM19_HUMAN	MRPL19	physical	17137291
RUSC2_HUMAN	RUSC2	physical	17137291
ECHD2_HUMAN	ECHDC2	physical	17137291

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.