MAEL_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MAEL_HUMAN
• UniProt AC: Q96JY0
• Protein Name: Protein maelstrom homolog
• Gene Name: MAEL
• Organism: Homo sapiens (Human).
• Sequence Length: 434
• Subcellular Localization: Cytoplasm . Nucleus . Component of the meiotic nuage, also named P granule, a germ-cell-specific organelle required to repress transposon activity during meiosis. Specifically localizes to piP-bodies, a subset of the nuage which contains secondary pi
• Protein Description: Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Its association with piP-bodies suggests a participation in the secondary piRNAs metabolic process. Required for the localization of germ-cell factors to the meiotic nuage (By similarity)..
• Protein Sequence: MPNRKASRNAYYFFVQEKIPELRRRGLPVARVADAIPYCSSDWALLREEEKEKYAEMAREWRAAQGKDPGPSEKQKPVFTPLRRPGMLVPKQNVSPPDMSALSLKGDQALLGGIFYFLNIFSHGELPPHCEQRFLPCEIGCVKYSLQEGIMADFHSFINPGEIPRGFRFHCQAASDSSHKIPISNFERGHNQATVLQNLYRFIHPNPGNWPPIYCKSDDRTRVNWCLKHMAKASEIRQDLQLLTVEDLVVGIYQQKFLKEPSKTWIRSLLDVAMWDYSSNTRCKWHEENDILFCALAVCKKIAYCISNSLATLFGIQLTEAHVPLQDYEASNSVTPKMVVLDAGRYQKLRVGSSGFSHFNSSNEEQRSNTPIGDYPSRAKISGQNSSVRGRGITRLLESISNSSSNIHKFSNCDTSLSPYMSQKDGYKSFSSLS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
11	Phosphorylation	RKASRNAYYFFVQEK CCCCCCCHHHHHHHH	12.35	-
95	Phosphorylation	LVPKQNVSPPDMSAL CCCCCCCCCCCCHHH	37.96	27251275
103	Phosphorylation	PPDMSALSLKGDQAL CCCCHHHHHCCCHHH	27.96	24719451
194	Phosphorylation	ERGHNQATVLQNLYR CCCCCHHHHHHHHHH	16.40	-
264	Phosphorylation	FLKEPSKTWIRSLLD HCCCCCHHHHHHHHH	30.38	30174305
268	Phosphorylation	PSKTWIRSLLDVAMW CCHHHHHHHHHHHHC	24.93	30174305
277	Phosphorylation	LDVAMWDYSSNTRCK HHHHHCCCCCCCCCC	9.85	30174305
278	Phosphorylation	DVAMWDYSSNTRCKW HHHHCCCCCCCCCCC	18.03	30174305
333	Phosphorylation	QDYEASNSVTPKMVV HHHCCCCCCCCCEEE	25.52	24719451
370	Phosphorylation	NEEQRSNTPIGDYPS CHHHHCCCCCCCCCC	19.96	28348404
375	Phosphorylation	SNTPIGDYPSRAKIS CCCCCCCCCCCCCCC	9.63	-
382	Phosphorylation	YPSRAKISGQNSSVR CCCCCCCCCCCCCCC	33.35	22210691
387	Phosphorylation	KISGQNSSVRGRGIT CCCCCCCCCCCCHHH	24.31	23911959
403	Phosphorylation	LLESISNSSSNIHKF HHHHHHCCCCCCHHC	28.49	22468782
416	Phosphorylation	KFSNCDTSLSPYMSQ HCCCCCCCCCHHCCC	17.38	22468782
418	Phosphorylation	SNCDTSLSPYMSQKD CCCCCCCCHHCCCCC	17.47	22468782

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MAEL_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MAEL_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MAEL_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PABP1_HUMAN	PABPC1	physical	24189637
YBOX1_HUMAN	YBX1	physical	24189637
FUBP2_HUMAN	KHSRP	physical	24189637
HNRPQ_HUMAN	SYNCRIP	physical	24189637
IF4A1_HUMAN	EIF4A1	physical	24189637
EIF3F_HUMAN	EIF3F	physical	24189637
ELAV1_HUMAN	ELAVL1	physical	24189637
DX39A_HUMAN	DDX39A	physical	24189637
IF4B_HUMAN	EIF4B	physical	24189637
ROA1_HUMAN	HNRNPA1	physical	24189637
ROA2_HUMAN	HNRNPA2B1	physical	24189637
FUBP1_HUMAN	FUBP1	physical	24189637
DDX1_HUMAN	DDX1	physical	24189637
DDX3X_HUMAN	DDX3X	physical	24189637
ILKAP_HUMAN	ILKAP	physical	29371914

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.