LPAR2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: LPAR2_HUMAN
• UniProt AC: Q9HBW0
• Protein Name: Lysophosphatidic acid receptor 2
• Gene Name: LPAR2
• Organism: Homo sapiens (Human).
• Sequence Length: 351
• Subcellular Localization: Cell surface . Cell membrane ; Multi-pass membrane protein . Prior to LPA treatment found predominantly at the cell surface but in the presence of LPA colocalizes with RALA in the endocytic vesicles.
• Protein Description: Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. Seems to be coupled to the G(i)/G(o), G(12)/G(13), and G(q) families of heteromeric G proteins. Plays a key role in phospholipase C-beta (PLC-beta) signaling pathway. Stimulates phospholipase C (PLC) activity in a manner that is independent of RALA activation..
• Protein Sequence: MVIMGQCYYNETIGFFYNNSGKELSSHWRPKDVVVVALGLTVSVLVLLTNLLVIAAIASNRRFHQPIYYLLGNLAAADLFAGVAYLFLMFHTGPRTARLSLEGWFLRQGLLDTSLTASVATLLAIAVERHRSVMAVQLHSRLPRGRVVMLIVGVWVAALGLGLLPAHSWHCLCALDRCSRMAPLLSRSYLAVWALSSLLVFLLMVAVYTRIFFYVRRRVQRMAEHVSCHPRYRETTLSLVKTVVIILGAFVVCWTPGQVVLLLDGLGCESCNVLAVEKYFLLLAEANSLVNAAVYSCRDAEMRRTFRRLLCCACLRQSTRESVHYTSSAQGGASTRIMLPENGHPLMDSTL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
10	N-linked_Glycosylation	IMGQCYYNETIGFFY CCEEEEECCEEEEEE	17.29	UniProtKB CARBOHYD
18	N-linked_Glycosylation	ETIGFFYNNSGKELS CEEEEEECCCCCCCH	30.91	UniProtKB CARBOHYD
232	Phosphorylation	HVSCHPRYRETTLSL HHCCCHHHHHHHHHH	19.77	30631047
235	Phosphorylation	CHPRYRETTLSLVKT CCHHHHHHHHHHHHH	24.84	22210691
236	Phosphorylation	HPRYRETTLSLVKTV CHHHHHHHHHHHHHH	15.03	26699800
238	Phosphorylation	RYRETTLSLVKTVVI HHHHHHHHHHHHHHH	29.08	26699800
295	Phosphorylation	SLVNAAVYSCRDAEM HHHHHHHHHCCHHHH	9.42	-
311	S-palmitoylation	RTFRRLLCCACLRQS HHHHHHHHHHHHHHH	1.31	-
318	Phosphorylation	CCACLRQSTRESVHY HHHHHHHHCCCEEEE	24.01	23403867
319	Phosphorylation	CACLRQSTRESVHYT HHHHHHHCCCEEEEC	30.07	28857561
322	Phosphorylation	LRQSTRESVHYTSSA HHHHCCCEEEECCCC	15.76	23403867
325	Phosphorylation	STRESVHYTSSAQGG HCCCEEEECCCCCCC	13.23	23403867
326	Phosphorylation	TRESVHYTSSAQGGA CCCEEEECCCCCCCC	11.00	23403867
327	Phosphorylation	RESVHYTSSAQGGAS CCEEEECCCCCCCCC	19.26	28857561
328	Phosphorylation	ESVHYTSSAQGGAST CEEEECCCCCCCCCE	19.46	28857561
334	Phosphorylation	SSAQGGASTRIMLPE CCCCCCCCEEEECCC	22.84	28857561
335	Phosphorylation	SAQGGASTRIMLPEN CCCCCCCEEEECCCC	24.55	23312004
349	Phosphorylation	NGHPLMDSTL----- CCCCCCCCCC-----	20.04	22617229
350	Phosphorylation	GHPLMDSTL------ CCCCCCCCC------	32.02	22617229

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of LPAR2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of LPAR2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of LPAR2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TRIP6_HUMAN	TRIP6	physical	14688263
TRIP6_HUMAN	TRIP6	physical	19293149
SIVA_HUMAN	SIVA1	physical	19293149
NHRF2_RAT	Slc9a3r2	physical	15143197
NHRF2_HUMAN	SLC9A3R2	physical	15143197
PLCB3_HUMAN	PLCB3	physical	15143197
HBB_HUMAN	HBB	physical	28514442
LEG3_HUMAN	LGALS3	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.