NHRF2_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NHRF2_RAT
• UniProt AC: Q920G2
• Protein Name: Na(+)/H(+) exchange regulatory cofactor NHE-RF2
• Gene Name: Slc9a3r2
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 337
• Subcellular Localization: Endomembrane system; Peripheral membrane protein. Nucleus. Apical cell membrane. Nuclear, in a punctate pattern. Localizes with EZR and PODXL at the apical cell membrane of glomerular epithelium cells and the sides of the food processes.
• Protein Description: Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. Necessary for cAMP-mediated phosphorylation and inhibition of SLC9A3. May also act as scaffold protein in the nucleus..
• Protein Sequence: MAAPESLRPRLCRLVRGEQGYGFHLHGEKGRRGQFIRRVEPGSPAEAAALRAGDRLVEVNGVNVEGETHHQVVHRIKAVEGQTQLLVVDKETDEELCRRQLTCTEEMAHRGLPPAHNPWEPKPDWACSGSLGSDTGHKDVNGPPRELRPRLCHLRRGPQGYGFNLHSDKSRPGQYIRSVDPGSPASLSGLRAQDRLIEVNGQNVEGLRHAEVVARIKAQEDEARLLVVDPETDEHFKRLRVVPTEDHVEGPLPSPVTNGTSLAQLNGGSVCSSRSDLPGSEKDNEDGSAWKRDPFQESGLHLSPTAAEAKEKARATRVNKRAPQMDWNRKREIFSNF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
6	Phosphorylation	--MAAPESLRPRLCR --CCCCHHHHHHHHH	28.72	30181290
43	Phosphorylation	IRRVEPGSPAEAAAL EEECCCCCHHHHHHH	31.49	30181290
130	Phosphorylation	PDWACSGSLGSDTGH CCCCCCCCCCCCCCC	17.17	-
183	Phosphorylation	IRSVDPGSPASLSGL EEECCCCCCCHHHHH	23.76	25575281
186	Phosphorylation	VDPGSPASLSGLRAQ CCCCCCCHHHHHCCC	26.84	22673903
188	Phosphorylation	PGSPASLSGLRAQDR CCCCCHHHHHCCCCC	33.03	22673903
244	Phosphorylation	KRLRVVPTEDHVEGP HCCEEECCCCCCCCC	42.30	30181290
254	Phosphorylation	HVEGPLPSPVTNGTS CCCCCCCCCCCCCCC	39.42	22108457
257	Phosphorylation	GPLPSPVTNGTSLAQ CCCCCCCCCCCCEEE	31.17	22668510
260	Phosphorylation	PSPVTNGTSLAQLNG CCCCCCCCCEEECCC	23.72	22668510
261	Phosphorylation	SPVTNGTSLAQLNGG CCCCCCCCEEECCCC	24.09	21630457
269	Phosphorylation	LAQLNGGSVCSSRSD EEECCCCCCCCCCCC	22.73	23984901
272	Phosphorylation	LNGGSVCSSRSDLPG CCCCCCCCCCCCCCC	26.99	23984901
273	Phosphorylation	NGGSVCSSRSDLPGS CCCCCCCCCCCCCCC	30.58	23984901
275	Phosphorylation	GSVCSSRSDLPGSEK CCCCCCCCCCCCCCC	45.51	23984901
280	Phosphorylation	SRSDLPGSEKDNEDG CCCCCCCCCCCCCCC	39.26	29779826
282	Acetylation	SDLPGSEKDNEDGSA CCCCCCCCCCCCCCC	68.50	22902405
288	Phosphorylation	EKDNEDGSAWKRDPF CCCCCCCCCCCCCCC	43.19	25575281
298	Phosphorylation	KRDPFQESGLHLSPT CCCCCCCCCCCCCCC	35.55	22673903
303	Phosphorylation	QESGLHLSPTAAEAK CCCCCCCCCCHHHHH	14.95	30240740
305	Phosphorylation	SGLHLSPTAAEAKEK CCCCCCCCHHHHHHH	34.81	22673903

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NHRF2_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NHRF2_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NHRF2_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of NHRF2_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.